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A kind of pharmaceutical composition and its preparation method, preparation and application
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A composition and drug technology, applied in the field of medicine, can solve problems such as limited effects, and achieve the effects of prolonging life, reducing damage, and improving heart function
Active Publication Date: 2020-08-07
昆明市中医医院
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[0003] For the treatment of heart failure patients, ACEI / ARB, β-receptor blockers, and aldosterone antagonists are advocated. They are called the "golden triangle" in the treatment of chronic heart failure. Inhibitors and aldosterone receptor antagonists can effectively reduce and prevent ventricular remodeling, reverse the failing myocardium, and reduce the mortality and hospitalization rate of heart failure.
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preparation example Construction
[0029] The preparation method of the pharmaceutical composition of the present invention includes pretreatment, extraction and posttreatment steps, specifically including:
[0030] A. Pretreatment: Weigh the raw materials in the formula ratio, and mix them to obtain material a;
[0031] B. Extraction:
[0032] 1) Add a solvent that is 3 to 8 times the weight of material a and soak at a temperature of 10 to 30°C for 1 to 2 hours to obtain material b;
[0033] 2) Decoction or reflux extraction of material b to obtain extract c;
[0034] C. Post-processing: the extract c is concentrated, dried, pulverized and sieved to obtain the target pharmaceutical composition.
[0035] The extraction described in step B is to add 3 to 8 times the weight of material a in water, soak at a temperature of 10 to 30°C for 1 to 2 hours to obtain material b; then decoct and extract at a temperature of 90 to 100°C for 1 to 3 times, each time 1~2h.
[0036] The extraction described in the B step is...
Embodiment 1
[0041] Weigh 1g of Salvia miltiorrhiza, 5g of curcuma, 5g of Radix Polygoni Multiflori, and 5g of hawthorn, and mix well to obtain material a; add water 8 times the weight of material a and soak for 2 hours at a temperature of 10°C to obtain material b; prepare material b at a temperature of 90°C Decocting and extracting for 3 times, 1 hour each time to obtain extract c; concentrating, drying, pulverizing and sieving the extract c to obtain the target pharmaceutical composition.
Embodiment 2
[0043] Weigh 5g of Salvia miltiorrhiza, 15g of turmeric, 15g of Radix Polygoni Multiflori, and 15g of hawthorn, and mix well to obtain material a; add 3 times the weight of material a in an ethanol solution with a volume percentage concentration of 80%, soak at a temperature of 30°C for 2 hours to obtain material b ; The material b was reflux extracted twice at a temperature of 90° C. for 2 hours each time to obtain an extract c; the extract c was concentrated, dried, pulverized and sieved to obtain the target pharmaceutical composition.
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Abstract
The invention discloses a medicine composition, and a preparation method, a preparation and application thereof. The medicine composition is prepared from the following raw materials in parts by weight: 1 to 5 parts of radix salviae miltiorrhizae, 5 to 15 parts of radix curcumae, 5 to 15 parts of radix polygoni multiflora and 5 to 15 parts of fructus crataegi, and is prepared through the steps of pretreatment, extraction and post treatment. The preparation method concretely comprises the following steps of weighing all raw materials according to the mixture ratio of a recipe; obtaining a material a after the uniform mixing; adding solvents being 3 to 8 times of the weight of the material a; performing soaking for 1 to 2h at the temperature being 10 to 30 DEG C to obtain a material b; decorating and boiling the material b or performing backflow extraction to obtain an extract c; and concentrating, drying, crushing and sieving the extract c to obtain a target material of the medicine composition. The preparation is a powder preparation, a tablet preparation, a capsule preparation, a granule preparation and a pill preparation prepared by adding pharmaceutically acceptable auxiliary materials into the medicine composition. The application is application of the medicine composition to preparation of medicine for treating chronic cardiac failure diseases. The medicine composition provided by the invention has the protection effect on intervening with the rat myocardial damage caused by Adriamycin.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition and its preparation method, formulation and application. Background technique [0002] Heart failure (heart failure) is one of the most serious complications of all different types of heart diseases. It seriously affects the quality of life of patients, threatens the lives of patients, and brings serious economic burdens to families and society. Due to factors such as bad living habits, environmental pollution, and the acceleration of the aging process of the population, the incidence of cardiovascular and cerebrovascular diseases such as coronary heart disease, high blood pressure, and diabetes in my country continues to rise, making the incidence of heart failure patients also increase year by year. Statistics from the United States show that there are about 5 million heart failure patients in the United States today, with an incidence ...
Claims
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Application Information
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