Liver oxygen-carrying mechanical perfusion device

Abstract

The invention provides a liver oxygen-carrying mechanical perfusion device which comprises a temperature control container as well as a first centrifugal pump, an oxygenator, a filtration and bubble discharge device, a flow controller, a first pressure sensor and a portal vein perfusion tube that are sequentially connected with one another by a pipeline to form a first perfusion circulation system, wherein the portal vein perfusion tube is connected with a portal vein of a liver. The liver oxygen-carrying mechanical perfusion device also comprises a suprahepatic vena cava tube, a second pressure sensor, an elastic water container and a second centrifugal pump that are sequentially connected with one another by a pipeline to form a second perfusion circulation system, wherein the suprahepatic vena cava tube is connected with a suprahepatic vena cava of the liver. The elastic water container and the second centrifugal pump are additionally arranged at a liver outflow tract to simulate physiological conditions; with the fluctuation of the pressure of the suprahepatic vena cava in a cardiac impulse process, the resistance of the liver outflow tract is regulated, so that the liver perfusion is more sufficient. According to the device, a marginal donor liver can be repaired, so that the liver confirms to the transplantation requirements, therefore, the liver donation source is greatly expanded.

Description

technical field [0001] The invention relates to the field of in vitro preservation devices for donated livers in transplantation surgery, in particular to a liver oxygen-carrying mechanical perfusion device. Background technique [0002] Due to the shortage of liver donors, the status of marginal liver donors as a method to expand the source of liver donors has attracted more and more attention. With the improvement of organ blood, preservation methods and surgical techniques, the criteria for marginal liver donors have gradually expanded. However, post-transplantation complications (PNF, IPF, rejection, vascular and biliary complications, etc.) brought about by marginal liver donors (cardiac death donors, fatty livers, elderly donors, etc.) are still a severe challenge for us . In-depth research on marginal liver donors can bring hope of recovery for more patients with end-stage liver disease. [0003] Because the resistance of each part of the liver is different, the pe...

AI Technical Summary

Problems solved by technology

In the early stage, the portal vein was infused with a catheter, and the superior and inferior hepatic vena cava and inferior hepatic vena cava were not treated, and the resistance of the hepatic outflow tract was very low. Later, in practice, some scholars found that this method may cause damage to the central large blood vessels of the liver. Excessive perfusion, but the surrounding tissue can not achieve effective perfusion, and then the subhepatic inferior vena cava is clamped, leaving only the superior and inferior hepatic vena cava as the outflow channel, so as to increase the resistance of the hepatic perfusate outflow channel, and effectively alleviate the phenomenon of uneven hepatic perfusion , but this method still does not fully perfuse

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