Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for determining content of glucose or glucose polymer in compound preparation

A technology of glucose polymer and compound preparation, applied in the direction of polarization influence characteristics, etc., can solve the problems of inability to measure glucose content and operation, poor accuracy and parallelism, and complexity, and achieve stable experimental results, good stability, and parallelism. Good results

Inactive Publication Date: 2018-01-09
HUAREN PHARMACEUTICAL CO LTD
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a method for measuring the content of glucose or glucose polymer in compound preparations, which solves the problem that the prior art cannot measure the content of glucose in compound preparations containing two or more optically active compounds and the operation is complicated and accurate. The problem of poor peace

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for determining content of glucose or glucose polymer in compound preparation
  • Method for determining content of glucose or glucose polymer in compound preparation
  • Method for determining content of glucose or glucose polymer in compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Adopt the method of the present invention to measure the content of glucose in the peritoneal dialysis fluid (lactate) containing sodium lactate, concrete steps are as follows. Of course, the determination method of the present invention is also applicable to the content of glucose or glucose polymer in compound preparations containing various optically active compounds such as sodium lactate.

[0056] 1. Preparation properties:

[0057] Compound preparation specifications: containing 2.27% anhydrous glucose, 2000mL;

[0058] [Prescription] as follows:

[0059]

[0060]

[0061] 2. Measurement method

[0062] (1) Since this product is a liquid with a relatively dilute concentration, no dilution is required for this product, that is, the dilution factor is 1.

[0063] (2) According to the above preparation method, the concentration C of other optically active compounds other than anhydrous glucose, i.e. sodium lactate, can be obtained 1 = 0.448%;

[0064] In t...

Embodiment 2

[0086] The method of the present invention is used to measure the maltodextrin content in the maltodextrin peritoneal dialysis fluid (lactate) containing maltodextrin and sodium lactate, and the specific steps are as follows. Of course, the determination method of the present invention is also applicable to the content of glucose or glucose polymer in compound preparations containing various optically active compounds such as sodium lactate.

[0087] 1. Preparation properties:

[0088] Compound preparation specifications: containing 6.0% maltodextrin, 2000mL;

[0089] [Prescription] as follows:

[0090]

[0091]

[0092] 2. Measurement method

[0093] (1) Since this product is a liquid with a relatively dilute concentration, no dilution is required for this product, that is, the dilution factor is 1.

[0094] (2) According to the above preparation method, the concentration C of other optically active compounds other than maltodextrin, namely sodium lactate, can be obt...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
specific rotationaaaaaaaaaa
specific rotationaaaaaaaaaa
specific rotationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for determining the content of glucose or a glucose polymer in a compound preparation, and belongs to the technical field of drug analysis and detection. The method comprises: (1) taking a compound preparation, and diluting to prepare a solution to be determined, wherein the dilution factor is Dil; (2) obtaining the concentration Cn of other optically active compounds excluding glucose or a glucose polymer in the solution to be determined; (3) according to an optical rotation determination method, determining the optical rotation [alpha] of the solution to be determined; and (4) calculating the content of the glucose or the glucose polymer according to the formula defined in the specification, wherein Fn is [alpha]n*L*Cn. According to the present invention,the content of the glucose or the glucose polymer in the compound preparation simultaneously containing two or more than two optically active compounds is determined by using the optical rotation determination method,, such that the method is simple, the operation is convenient, the result is stable and accuracy, and the parallelism is good.

Description

technical field [0001] The invention belongs to the technical field of drug analysis and detection, in particular to a method for measuring the content of glucose or glucose polymer in compound preparations. Background technique [0002] The second part of the Pharmacopoeia of the People's Republic of China 2010 stipulates that the content of glucose in compound preparations, such as glucose injection, should be determined by polarimetry. The determination of glucose content by this polarimetric method is to determine the glucose content in the compound preparation by the specific rotation of the test sample and the pure glucose sample. Therefore, this method for measuring the glucose content is only used in compound preparations containing only one In the case of an optically active compound. When the compound preparation contains two or more compounds with optical activity at the same time, the optical polarimetry method cannot accurately measure the content of glucose. M...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/21
Inventor 沈圣民张旭东
Owner HUAREN PHARMACEUTICAL CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com