Application of EGFR/HER2 (epidermal growth factor receptor/type-2 human epidermal growth factor receptor) receptor tyrosine kinase inhibitors to preparing medicines for treating cancer
A technology for use and cancer, applied in drug combinations, antibodies, anti-tumor drugs, etc., can solve the problems of undisclosed cancer use of the compound of formula I, combined use of antibody-drug conjugates with undisclosed anti-HER2 effects, etc.
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[0027]Example 1: The effect of compound (I), T-DM1 alone or both in combination on Herceptin drug-resistant human breast cancer BT-474 / T721 subcutaneously transplanted tumors in nude mice
[0028] 1. Test drugs
[0029] Drug name and batch number: Compound (I) is a yellow powder with a content of 98.8%, batch number S0915100514; T-DM1 is a white freeze-dried powder, specification 80mg / bottle, batch number P07A113010711.
[0030] Drug source: Compound (I) is administered in the form of its dimaleate, which is prepared according to the method disclosed in CN102933574B; T-DM1 is prepared according to the method disclosed in CN101087611A.
[0031] Preparation method: Compound (I) was prepared with distilled water; T-DM1 was first reconstituted with distilled water to form a 20 mg / ml solution, subpackaged and stored at -80°C, and diluted with 0.1% BSA saline to the corresponding concentration before use.
[0032] 2. Experimental animals
[0033] BALB / cA-nude nude mice, 6-7 weeks ...
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