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Polymalic acid coating-containing titanium alloy vascular stent

A technology of polymalic acid and vascular stents, applied in the field of stents, can solve the problems of short release time and insufficient drugs, and achieve the effects of prolonging release time, improving release efficiency, good biocompatibility and degradability

Inactive Publication Date: 2018-02-06
成都测迪森生物科技有限公司
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

[0005] But when polymalic acid is introduced into the stent, because the coating on the surface of the stent is very thin, the drug that can be loaded is not enough, the release time is short, and a large amount of drug will be released in a short time

Method used

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Examples

Experimental program
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Effect test

specific Embodiment 1

[0023] Specific embodiment 1: a titanium alloy vascular stent containing a polymalic acid coating, comprising a titanium alloy stent body and a polymalic acid coating, the polymalic acid coating is multi-monomer graft modification, the The grafting monomers are glucose and 2-amino-3-p-hydroxyphenylpropionic acid monomers, and the monomers and polymalic acid repeating units are in molar fractions: 100 parts of polymalic acid repeating units, 10 parts of glucose 2 parts, 2 parts of 2-amino-3-p-hydroxyphenylpropionic acid.

[0024] The preparation method is as follows:

[0025] Step 1, inserting the bacterial strain into the medium for cultivation, and culturing at 28° C. for 40 hours;

[0026] Step 2, inoculating the above-mentioned culture solution into the fermentation medium according to the inoculum amount of 5%, and culturing at 25-30° C. for 48 hours;

[0027] Step 3, centrifuging the above fermented liquid for 20 minutes, collecting the cells, heating in a water bath, t...

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PUM

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Abstract

The invention discloses a polymalic acid coating-containing titanium alloy vascular stent, and belongs to the field of medical materials. The grafting monomer comprises glucose and 2-amino-3-p-hydroxyphenylpropionic acid monomers, and the molar ratio of the glucose monomer to the 2-amino-3-p-hydroxyphenylpropionic acid monomer is 1 to (1 to 10).

Description

technical field [0001] The present invention relates to the field of stents. Background technique [0002] Cardiac stent (Stent), also known as coronary stent, is a medical device commonly used in cardiac interventional surgery and has the function of dredging arteries. The main materials are stainless steel, nickel-titanium alloy or cobalt-chromium alloy. [0003] Existing metal stents easily lead to restenosis of blood vessels. In a new type of stent, anti-thrombotic and anti-proliferative drugs are wrapped on the heart stent. After the stent is implanted, the drug is released slowly, which can increase the local drug concentration, reduce side effects, and reduce the rate of restenosis. [0004] Existing drug carriers generally include biodegradable and non-degradable polymer materials. In biodegradable polymer materials, the drug release rate is low and the effective time is short. The commonly used degradable material carriers include polylactic acid, polyglycolic ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/14
CPCA61L31/022A61L31/10A61L31/14A61L31/148C08L67/04
Inventor 郑浩
Owner 成都测迪森生物科技有限公司
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