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Structure, preparation and application of novel polyhedral multi-channel high-throughput chromatographic device

A polyhedral structure and chromatographic device technology, applied in the field of biochemical analysis, can solve the problems of sample waste, inability to detect multiple samples, and inability to detect

Inactive Publication Date: 2018-07-06
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this type of design are: (1) it is not possible to test multiple indicators on one sample at the same time, (2) it is not possible to test multiple indicators on multiple samples at the same time, which is easy to cause waste of samples

Method used

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  • Structure, preparation and application of novel polyhedral multi-channel high-throughput chromatographic device
  • Structure, preparation and application of novel polyhedral multi-channel high-throughput chromatographic device
  • Structure, preparation and application of novel polyhedral multi-channel high-throughput chromatographic device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, the preparation of polyhedron chromatography device

[0038] Required materials: One Upbox-3D printer was purchased from Beijing Taier Times Technology Co., Ltd. The raw materials ABS, PLA, resin, and polylactic acid were purchased from Beijing Sandi Technology Co., Ltd.

[0039] Operation steps: ① Design the structural model by Auto CAD or SolidWorks software according to the actual needs; ② Input the design model into the Upbox-3D printer for 3D printing.

Embodiment 2

[0040] Example 2, assembly and detection method of 2-channel uplink dihedral chromatography device

[0041] Required materials: single-sample 2-channel housing ( figure 1 ), samples, test strips.

[0042] Operation steps: Assembly of single-sample multi-channel device: ① Pass the upper and lower parts of the shell through ( figure 1 )5 parts for connection; ② Insert the 2 sample test strips into the housing ( figure 1 ) in the 1-like structure; ③ take the sample from the shell ( figure 1 ) into 2, gently pipet twice, and the sample passes through the liquid separator ( figure 1 )4 are equally divided one by one; ④ about 5-20min, generally after 10min ( figure 1 ) 3 places to observe the test results.

Embodiment 3

[0043] Example 3, assembly and detection method of 3-channel uplink trihedral chromatography device

[0044] Required materials: single-sample 3-channel housing ( figure 2 ), samples, test strips.

[0045] Operation steps: ①Pass the upper and lower parts of the shell through ( figure 2 ) 4 parts to connect; ② Insert the 3 sample test strips into the housing ( figure 2 ) in the 1-like structure; ③ take the sample from the shell ( figure 2 ) into 2, gently pipet twice, and the sample passes through the liquid separator ( figure 2 )5 divided equally one by one; ④ about 5-20min, generally after 10min ( figure 2 ) 3 observations and test results

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Abstract

The invention discloses a novel polyhedral multi-channel high-throughput chromatographic device and application thereof. The device is of a polyhedral structure; the main part of the device is a shell; the device may further have a top cover and a pedestal; and the shell is filled with a drying agent, and the bottom and the top of the device are connected with stepping equipment. The device can realize multi-channel vertical ascending or descending chromatography and perform high-throughput parallel detection and analysis of a plurality of marker molecules on one or more clinical or non-clinical samples at the same time; the device can realize automatic or semi-automatic, qualitative and quantitative analysis with the naked eye in the aid of automatic sample loading, spectroscopic or electromagnetic wave spectrometers and analytical assemblies; target objects to be detected may be biomacromolecules and small-molecular compounds like proteins, nucleic acids and sugars and may be cellular and subcellular components and the like; so the device is applicable to fields like clinical diagnosis, inspection and quarantine, food safety testing, judicial expertise and drug detection. The device is simple to operate, convenient to carry and capable of significantly improving detection efficiency and reducing sample amount.

Description

technical field [0001] The invention relates to an analysis and detection device, which belongs to the field of biochemical analysis, in particular to a polyhedral multi-channel chromatography device, which can simultaneously perform rapid detection of multiple indicators on one sample or multiple samples. Background technique [0002] Immunochromatography is a common rapid detection technology. Usually, the specific antibody is first bound to a specific membrane, and one end of the membrane is immersed in the sample solution, and the sample moves forward along the membrane. When there is an antibody region, the corresponding antigen in the sample will specifically react with the antibody, and then combined with detection methods such as visible light, chemiluminescence, fluorescence, and Raman, the qualitative and quantitative analysis of the antigen content in the sample is carried out. [0003] Immunochromatography technology is widely used in biochemical analysis, pestic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558
CPCG01N33/558
Inventor 王升启王娈娈张敏丽王琼
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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