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Composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles

A technology for hair growth and composition, applied in the field of compositions of exosome-like vesicles, can solve problems such as hair growth effects that have not been reported, and achieve the effects of preventing hair loss and promoting hair growth

Active Publication Date: 2018-07-17
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, exosomes have been mainly used as biomarkers, and the technology to use exosomes for specific applications by utilizing their own efficacy has yet to be developed
In particular, little is known about the specific application of exosome-like membrane-structured vesicles derived from plant cells. In the case of ginseng, although hair growth effects of ginseng-derived extracts or individual fractions have been reported, The hair growth effect of exosome-like membrane-structured vesicles, which are complex physiologically active substances extracted from ginseng, has not been reported

Method used

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  • Composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles
  • Composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles
  • Composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Example 1. Isolation of ginseng-derived exosome-like vesicles

[0084] (Step 1) First, 4-year-old ginseng roots were prepared and pressed to prepare juice containing ginseng root extracellular fluid.

[0085] (Step 2) The juice was centrifuged at 500×g for 10 minutes at 4°C to obtain a supernatant, and the supernatant was centrifuged again at 3,000×g for 20 minutes at 4°C to obtain a supernatant.

[0086] (Step 3) 0.5 ml of 2.0 M sucrose, 1 ml of 0.8 M sucrose and 32 ml of the supernatant from which foreign matters were removed were sequentially added to a 35 ml ultracentrifuge tube, and ultracentrifuged at 100,000×g for 2 hours at 4° C. After ultracentrifugation, ginseng root exosome-like vesicles were placed between the 2.0 M sucrose layer and the 0.8 M sucrose layer by density. Thereafter, the solution was removed from the top of the tube to isolate the layer containing ginseng root exosome-like vesicles.

[0087] (Step 4) The thus isolated layer containing exosome...

Embodiment 2

[0103] [Dosage Form Example 2] Tablet

[0104] Mix 50 mg of the ginseng-derived exosome-like vesicles of Example 1, 200 mg of galacto-oligosaccharides, 60 mg of lactose and 140 mg of maltose, use a fluidized bed dryer to granulate the mixture, add 6 mg of sugar esters to the granules and then press The tablet machine compresses the mixture to make tablets.

Embodiment 3

[0105] [Dosage Form Example 3] Granules

[0106] 50 mg of the ginseng-derived exosome-like vesicles of Example 1, 250 mg of anhydrous crystalline glucose, and 550 mg of starch were mixed, the mixture was granulated using a fluidized bed granulator, and the granules were packed into bags to prepare granules.

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Abstract

Disclosed in the present specification are: a composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles; and a method for preparing the composition. The ginseng-derived exosome-like vesicles can have a diameter of 20-500 nm and can be isolated from ginseng root. The composition contains ginseng-derived exosome-like vesicles as active ingredients, thereby having an effect of inducing hair growth by activating dermal papilla cells (DPCs).

Description

technical field [0001] The present specification discloses a composition containing ginseng-derived exosome-like vesicles for preventing hair loss or promoting hair growth; and a method for preparing the composition. Background technique [0002] Most animal cells have the ability to secrete extracellular vesicles of intracellular origin that vary in size and composition. These extracellular vesicles are present in all biological fluids, including blood, urine, saliva, and cell culture fluids (Loyer X, Vion AC, Tedgui A, Boulanger CM. Microvesicles as cell-cell messengers in cardiovascular diseases. Circ Res 2014; 114:345-53) (Ohno S, Ishikawa A, Kuroda M. Roles of exosomes and microvesicles in disease pathogenesis. Adv Drug Deliv Rev 2013; 65:398-401). [0003] Extracellular vesicles are membrane-structured vesicles with diameter dimensions ranging from about 20 nanometers to about 5 micrometers. They are heterogeneous in size and composition and include several different...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K8/9789A61Q7/00A61P17/14
CPCA61Q7/00A61K36/258A61K8/14A61K8/9789A61P17/14
Inventor 崔银廷李龙喜辛承炫黄景焕曹恩敬李泰龙
Owner AMOREPACIFIC CORP
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