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A random copolymer solution of n-vinylpyrrolidone and n-vinylcaprolactam and its preparation method

A technology of vinylpyrrolidone and vinylcaprolactam, which is applied in the field of free radical solution polymerization, and can solve the problems of limited use scope, product safety impact, etc.

Active Publication Date: 2020-11-17
BOAI NKY PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In the above-mentioned methods, it is impossible to obtain a clear aqueous solution with only two structural unit copolymers of NVP and NVCL. Due to the introduction of other crosslinking agents or monomers, the safety of the product is affected, thereby limiting its scope of use.

Method used

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  • A random copolymer solution of n-vinylpyrrolidone and n-vinylcaprolactam and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Put 450 parts of ethanol, 18 parts of NVP, and 90 parts of NVCL into the reactor, slowly raise the temperature to 55°C under vigorous stirring, add 22.5 parts of azobisisobutyronitrile immediately after reaching the temperature, and start adding 342 parts of NVP. Dosing is completed within 8 hours. After that, 0.3 part of azobisisobutyronitrile was added and kept at a constant temperature for 5 hours, and the reaction was completed. Ethanol in the reaction solution was evaporated under reduced pressure using a rotary evaporator, and then 1800 parts of water was added for further evaporation to finally obtain a random copolymer solution with a solid content of 30 wt%.

Embodiment 2

[0040] Put 65 parts of water, 195 parts of ethanol, 18 parts of NVP, and 20 parts of NVCL into the reactor, slowly raise the temperature to 65°C under vigorous stirring, add 0.50 parts of azobisisobutyronitrile immediately after the temperature reaches, and start adding 78 parts of NVP, This part of NVP was added within 1.5 hours. After that, 0.06 part of azobisisobutyronitrile was added and kept at a constant temperature for 5 hours, and the reaction was completed. The water and ethanol in the reaction liquid were evaporated under reduced pressure using a rotary evaporator, and then 250 parts of water were added for further evaporation to finally obtain a random copolymer solution with a solid content of 30%.

Embodiment 3

[0042] Put 102 parts of water, 918 parts of isopropanol, 18 parts of NVP, and 160 parts of NVCL into the reactor, slowly raise the temperature to 60°C under vigorous stirring, add 0.50 parts of pivalate peroxide immediately after the temperature reaches, and start adding NVP162 Parts, this part of NVP is added within 1.0 hours. After that, 0.18 parts of peroxypivalic acid ester was added and kept at a constant temperature for 3 hours, and the reaction was completed. The water and isopropanol in the reaction solution were evaporated under reduced pressure using a rotary evaporator, and then 2000 parts of water were added for further evaporation to finally obtain a random copolymer solution with a solid content of 50 wt%.

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Abstract

The invention provides an N-vinyl pyrrolidone and N-vinyl caprolactam random copolymer solution and a preparation method thereof. The random copolymer solution is a homogeneous solution of the binaryrandom copolymer of N-vinyl pyrrolidone (NVP) and N-vinyl caprolactam, the random copolymer comprises 20 wt%-80 wt% of NVP and 20 wt%-80 wt% of NVCL, the solid content of the copolymer solution is 10wt%-50 wt%, and a cloud point is 39 DEG C-92 DEG C. The obtained random copolymer solution of N-vinyl pyrrolidone and N-vinyl caprolactam is clear and transparent under room temperature, the viscosityis 2000 cP-25000 cP, and the cloud point can be adjusted at 39 DEG C-92 DEG C.

Description

technical field [0001] The present invention relates to a random copolymer solution of N-vinylpyrrolidone and N-vinylcaprolactam and a preparation method thereof. The copolymer is a binary homogeneous copolymer of N-vinylpyrrolidone and N-vinylcaprolactam , the polymerization method involved is free radical solution polymerization. Background technique [0002] Poly(N-vinylcaprolactam) (PNVCL) has low toxicity, good temperature sensitivity, biocompatibility and biodegradability. Its lower critical solution temperature (LCST) can be regulated by the length of the polymer chain segment and the concentration of the solution, and it has a wide range of applications in the field of biomedicine. Poly N-vinylpyrrolidone (PVP) has been approved by the FDA as a food additive, and has the characteristics of low toxicity, good water solubility and biocompatibility. [0003] The temperature sensitivity mainly depends on the proportion of hydrophobic groups and hydrophilic groups in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F226/06C08F226/10C08F2/00
CPCC08F2/00C08F226/06C08F226/10
Inventor 孙旭东牛磊张森林
Owner BOAI NKY PHARMA LTD
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