Silk fibroin block material and preparation method thereof

Abstract

The invention provides a silk fibroin block material and a preparation method thereof. The preparation method comprises: preparing a silk fibroin aqueous solution; preparing silk fibroin dry powder; dissolving the silk fibroin dry powder in hexafluoroisopropanol to form a silk fibroin fluoroisopropanol solution; transferring the silk fibroin hexafluoroisopropanol solution into an injection device,and standing until gas bubbles are completely released; injecting the silk fibroin hexafluoroisopropanol solution into a porous mold, and standing until the gas bubbles in the solution are completelyreleased; replacing the hexafluoroisopropanol with methanol while carrying out crystallization curing to obtain a silk fibroin solid; replacing the methanol in the silk fibroin solid with water by using a gradient displacement method; and carrying out air drying on the silk fibroin solid, and carrying out cutting shaping to obtain the required block material. According to the present invention, the prepared silk fibroin block material has characteristics of large volume, low gas bubble content, uniform component, controllable molecular weight and controllable mechanical property, and can be widely used in biological implant devices, degradable tableware, toys and other fields.

Description

technical field [0001] The invention belongs to the technical field of organic polymer materials, and relates to a silk fibroin block and a preparation method thereof, in particular to a silk fibroin with large volume, low air bubble content, uniform composition, adjustable molecular weight and mechanical properties of silk fibroin. Vegetarian protein block and its preparation method. Background technique [0002] Bio-based materials with excellent performance, environmental friendliness, variety, high added value and wide application have always been one of the important areas for the development of my country's strategic emerging industries and biomass industry. Biomacromolecular materials, especially biomacromolecular materials of natural products, have many unique advantages in the field of polymer materials, such as good biocompatibility, degradable characteristics and wide range of sources. [0003] As a biological material with a long history of application, silk pro...

AI Technical Summary

Problems solved by technology

However, the current methods for preparing porous silk fibroin scaffolds and films are difficult to prepare silk fibroin blocks with large volume, low air bubble content and uniform composition.

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