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Applications of niclosamide ethanolamine salt and medicinal composition thereof

A technology of niclosamide ethanolamine salt and composition, which is applied in the field of application of niclosamide ethanolamine salt and its pharmaceutical composition, can solve the problem that there is no effective drug for delaying the progress of kidney disease, and achieve the prevention and treatment of kidney disease. disease, improving glomerulosclerosis and tubular damage, and reducing serum creatinine levels

Inactive Publication Date: 2018-08-24
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of application of niclosamide ethanolamine salt and its pharmaceutical composition, which solves the problem that there is no effective drug for delaying the progress of kidney disease in the prior art

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  • Applications of niclosamide ethanolamine salt and medicinal composition thereof
  • Applications of niclosamide ethanolamine salt and medicinal composition thereof
  • Applications of niclosamide ethanolamine salt and medicinal composition thereof

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Embodiment Construction

[0021] The pharmaceutical composition of calcium-sensing receptor-related peptides of the present invention and its application will be further described below in conjunction with the accompanying drawings and examples:

[0022] Kidney disease is mainly caused by increased urine protein excretion caused by kidney damage. Proteinuria can also aggravate kidney damage, leading to glomerular sclerosis and renal tubular damage, which in turn leads to decreased glomerular filtration function and progressive increase in serum creatinine. Eventually move towards renal failure, the etiology of this disease is complicated, the pathogenesis is not completely clear, and the treatment is difficult.

[0023] The invention provides the application of niclosamide ethanolamine salt (NEN) and a pharmaceutical composition containing niclosamide ethanolamine salt (NEN) in the preparation of medicines for treating and preventing kidney diseases. Wherein, niclosamide ethanolamine salt (NEN) is the ...

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Abstract

The invention relates to applications of niclosamide ethanolamine salt and a medicinal composition of the niclosamide ethanolamine salt. After the niclosamide ethanolamine salt and the medicinal composition of the niclosamide ethanolamine salt are applied, an uncoupling effect can be achieved on the kidney tissue mitochondria, the excretion of proteinuria of mice with kidney diseases can be reduced, the glomerular sclerosis and renal tubular injuries can be improved, the level of serum creatinine can be reduced, and therefore, the niclosamide ethanolamine salt and medicinal composition of theniclosamide ethanolamine salt have a certain protection effect for the kidney diseases, and can be used for preventing and treating the kidney diseases.

Description

technical field [0001] The present invention relates to the technical field of kidney medicine, more specifically, relates to the application of a niclosamide ethanolamine salt and a pharmaceutical composition thereof. Background technique [0002] Kidney disease is a major chronic non-communicable disease that threatens human health. The etiology of the disease is complex, the treatment of the disease is difficult, the condition is lingering and difficult to heal, and the medical expenses are huge. Proteinuria, progressive increase in serum creatinine, glomerulosclerosis and renal tubular damage are the main clinical features in the early stage. At present, there is no clinically effective drug for delaying the progression of kidney disease. [0003] Niclosamide is a molluscicide and anthelmintic drug recommended by WHO. Niclosamide ethanolamine salt (NEN) is its derivative, which has better water solubility. Recent studies have shown that this type of drug has obvious An...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61P13/12
CPCA61K31/167A61P13/12
Inventor 易铁钢李顺民孙惠力韩鹏勋邵牧民王太芬
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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