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A kind of renal sperm icp-ms identification method and its application

An ICP-MS, SIMCA-P14.1 technology, applied in the field of renal sperm ICP-MS identification, can solve the problems of uneven quality, unfavorable quality control of medicinal materials, confusion in the market of renal sperm medicinal materials, etc., and achieve the effect of simple and fast method.

Active Publication Date: 2021-02-02
SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to literature records, kidney sperm has the effect of promoting water and reducing swelling, and it is used in clinical medicine to treat "diarrhea". Professor Yinhuihe's "Shugan Sanjie Prescription" mentioned that the use of kidney sperm single herbal medicine also has a miraculous effect, but at present There is no quality standard for kidney sperm, the market of kidney sperm medicinal materials is chaotic, good and bad are mixed, and there is a lack of effective and reliable quality monitoring methods, which is not conducive to the quality control of medicinal materials
There is no effective identification method and monitoring method for the uniform stability of different batches of kidney sperm and the species source of kidney sperm

Method used

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  • A kind of renal sperm icp-ms identification method and its application
  • A kind of renal sperm icp-ms identification method and its application
  • A kind of renal sperm icp-ms identification method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The construction process of the kidney sperm ICP-MS identification method of the present invention.

[0027] A total of 12 batches of kidney sperm of 2 different varieties were collected from the market (6 batches for each variety, of which 1-6 were bovine (N); 7-12 were pig-derived (Z))

[0028] 1. Determination of the inorganic element spectrum of 12 batches of kidney sperm of the above-mentioned different varieties.

[0029] (1) Precisely weigh 0.1g of the above-mentioned kidney sperm powder into a beaker, add 10 mL of 65% nitric acid and 1 mL of perchloric acid respectively, cover the glass dish and let it stand overnight, then place it on an electric heating plate for wet digestion at 180°C until it reaches liquid After clarification and transparency, rinse the acid on the electric heating plate until about 1mL of liquid remains, add ultrapure water to dilute to a 50mL colorimetric tube.

[0030] (2) Before the test, the sample was diluted 20 times, and tested wit...

Embodiment 2

[0038] A method for identifying kidney sperm ICP-MS, comprising the following steps:

[0039] (1) Perform wet digestion on the samples of known basic kidney sperm and different batches of kidney sperm to be tested: accurately weigh 0.1 g into a beaker, add 10 mL of 65% nitric acid and 1 mL of perchloric acid respectively, cover the glass dish and let it stand overnight, then put it on an electric heating plate for wet digestion at 180°C, digest until the liquid is clear and transparent, then rinse the acid on the electric heating plate until the liquid remains 1mL, add ultrapure water to make up to 50mL colorimetric tube.

[0040](2) Dilute the above-mentioned known basic kidney sperm and different batches of kidney sperm to be tested and dilute them 20 times for ICP-MS measurement to obtain Li, Na, Mg, Al, P, S, K, Ca, Ti , V , Mn , Co , Ni , Cu, Zn, In, Ba, U, a total of 18 elements; the specific measurement conditions are to adjust the sensitivity of the instrument before ...

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Abstract

The present invention relates to a method for identifying traditional Chinese medicine for animal stones, in particular to a method and application for identifying kidney sperm by ICP-MS; performing wet digestion on samples of known basic kidney sperm and different batches of kidney sperm to be tested Perform ICP-MS measurement to obtain data of 18 elements including Li, Na, Mg, Al, P, S, K, Ca, Ti, V, Mn, Co, Ni, Cu, Zn, In, Ba, U; and then Import the measured data into SPSS 22.0 software for cluster analysis, and use the "inter-group connection" clustering method to generate a dendrogram, so as to distinguish whether the kidney sperm to be tested is the same as the known basic kidney sperm species; or import the data into the SIMCA-P 14.1 software for PCA analysis to obtain a PCA scatter diagram, and at the same time determine the uniform stability of different batches of kidney sperm to be tested according to the degree of aggregation in the scatter diagram; The identification of the species source of kidney sperm in terms of element composition can also be used to identify the uniform stability of different batches of kidney sperm, and the method is simple and quick.

Description

technical field [0001] The invention relates to an identification method of traditional Chinese medicine for calculi in animals, in particular to an ICP-MS identification method and application of kidney sperm. Background technique [0002] The quality uniformity of traditional Chinese medicine preparations has always been a hot issue. The quality uniformity of traditional Chinese medicine preparations directly affects the safety and effectiveness of clinical medication, and is also related to the health and safety of patients. However, there are many factors that affect the uniform quality of traditional Chinese medicine preparations. Among them, the diversification of sources of Chinese medicinal materials, "one drug with multiple bases" and the uniformity and stability of different batches of Chinese medicinal materials will all affect the quality of traditional Chinese medicine prepared using them as raw materials. The uniformity of the formulation is affected. [0003]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/73
CPCG01N21/73
Inventor 赵思俊王春芳崔宇红罗晋萍郭景文张蕻刘馨曲萍
Owner SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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