Breast cancer screening model suitable for Chinese women and establishing method thereof

A breast cancer, model technology, applied in medical simulation, medical informatics, medical automatic diagnosis and other directions, can solve the problems of high cost, limited model popularization and application, not meeting the requirements of health economics, etc., to achieve simple structure, improve diagnosis accuracy, etc. rate, the effect of highlighting substantive characteristics

Inactive Publication Date: 2018-08-24
SHANDONG UNIV
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  • Application Information

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Problems solved by technology

Although the screening efficiency has been improved after the inclusion of SNP in the model, its geographical characteristics and genetic testing technology lim

Method used

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  • Breast cancer screening model suitable for Chinese women and establishing method thereof
  • Breast cancer screening model suitable for Chinese women and establishing method thereof
  • Breast cancer screening model suitable for Chinese women and establishing method thereof

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Experimental program
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Embodiment 1

[0044] This embodiment provides a breast cancer screening model suitable for Chinese women, characterized in that the model is defined as y=1.0×a+6.7×b+9.1×c+6.0×d+1.2×e+6.9×f +3.4×g+1.1×h+1.8×j;

[0045] in,

[0046] a stands for age;

[0047] b represents whether there is a history of benign breast tumors, if yes, it is assigned a value of 1, and if not assigned a value of 0;

[0048] c represents whether there is a history of diabetes, if yes, it is assigned a value of 1, and if not assigned a value of 0;

[0049] d represents the living area, the value of living in rural areas is 2, and the value of living in cities is 1;

[0050] e represents the age of the first full-term childbirth; when the age is less than or equal to 25 years old, the value is 1, when the age is between 25 and 29 years old, the value is 2, and when the age is greater than or equal to 30 years old, the value is 3;

[0051] f represents whether there is a family history of breast cancer, if there i...

Embodiment 2

[0056] This embodiment provides a method for establishing a breast cancer screening model suitable for Chinese women, which is characterized in that it includes the following steps:

[0057] S1: Carry out a case-control study of the whole population. Risk factor investigation was performed using case and control data matched 1:2. Establish a multiple logistic regression model to estimate the relative risk rr of each risk factor 1 (t,X), and estimate the population attributable risk AR(t);

[0058] S2: According to the active breast cancer surveillance system for the whole population, the age-specific breast cancer incidence rate is obtained, and the baseline risk is calculated. The formula is:

[0059] h 10 (t)={1-AR(t)}h 1 * (t),

[0060] Among them, h 10 (t) is the baseline risk to be estimated, AR(t) is the population attributable risk, h 1 * (t) is the age-specific breast cancer incidence rate;

[0061] S3: According to the all-cause surveillance system, the age-...

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Abstract

The invention relates to a breast cancer screening model suitable for Chinese women and an establishing method thereof. The breast cancer screening model is characterized in that the model is definedas y=1.0xa+6.7xb+9.1xc+6.0xd+1.2xe+6.9xf+3.4xg+1.1xh+1.8xj, wherein a represents age, b represents the history of benign breast tumors, the value is 1 if there is the history, or the value is 0; c represents the history of diabetes, the value is 1 if there is the history, or the value is 0; d represents the residential area, the value is 2 if the residential area is the rural area, and the value is 1 if the residential area is the urban area; e represents the first time of full term birth age; f represents the family history of breast cancer, the value is 1 if there is the family history, or the value is 0; g represents the current life satisfaction, the value is 1 if the satisfaction is greater than or equal to 13, and the value is 0 if the satisfaction is less than 13; h represents the body mass index; and j represents the times of abortion.

Description

technical field [0001] The invention belongs to the technical field of disease prevention and control model design, and specifically relates to a breast cancer screening model and a method for establishing the same; in particular, a breast cancer screening model suitable for Chinese women and a method for establishing the same. Background technique [0002] Breast cancer is one of the most common malignant tumors in women around the world, accounting for 1 / 4 of the total number of new cancers in women, and the mortality rate accounts for 15% of cancers in women. huge impact. The data in the "Global Cancer Report 2014" shows that in 2012, the number of new cases of female breast cancer in the world exceeded 1.677 million, accounting for 25.2% of new cancers in women. 11.2 percent. According to the 2014 China Cancer Registration Annual Report, the incidence of breast cancer in Chinese women reached 42.55 / 100,000 in 2012. Although my country is currently a country with a low...

Claims

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Application Information

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IPC IPC(8): G16H50/50G16H50/30G16H50/20
CPCG16H50/20G16H50/30G16H50/50
Inventor 余之刚薛付忠贾存显
Owner SHANDONG UNIV
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