Valsartan tablets and preparation method thereof

Abstract

The invention discloses valsartan tablets and a preparation method thereof. The preparation method comprises the following treatment steps: weighing and mixing valsartan, microcrystalline cellulose, lactose, anhydrous silica gel, crosslinking povidone, hydroxypropyl methylcellulose, lauryl sodium sulfate, microcrystalline cellulose, talcum powder and magnesium stearate according to a certain ratio; screening and filtering the weighed materials through a shaking sieve; carrying out dry mixing on the screened materials, the microcrystalline cellulose, crosslinking povidone, the anhydrous silicagel, the valsartan and the lactose for 2min; adding a granulation solution prepared from the hydroxypropyl methylcellulose, lauryl sodium sulfate and purified water; mixing the granulation solution with the dry-mixed materials to finish granulation. The valsartan tablets and the preparation method thereof relate to the technical field of medicines. According to the valsartan tablets and the preparation method thereof, the aims of ensuring the integrity and stability of the granules, improving the yield of valsartan grains, uniformly mixing the materials of the valsartan tablets, ensuring thatcomponents of the pharmacological components are uniformly distributed in the valsartan tablets and reducing a condition that the content of the valsartan in the valsartan tablets exceeds the standardto cause a great side effect are realized.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a valsartan tablet and a preparation method thereof. Background technique [0002] Valsartan tablets are indicated for essential hypertension. According to foreign clinical research data, it is absorbed rapidly after oral administration, with an absolute bioavailability of 25%, and the absorption rate decreases by 46% after taking food, but the clinical efficacy is not significantly reduced, so it can be taken with or without food. The plasma peak time is 2 to 3 hours, the elimination half-life is 6 to 7 hours, and the plasma protein binding rate is 94% to 97%. The drug is taken once a day, and the plasma concentration reaches a steady state after three days. Valsartan is metabolized by the prototype drug, mainly (70%) is excreted through the biliary tract, and the rest is excreted through the kidneys. Although there is no experience of valsartan overdose, the main symptom th...

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies in the prior art, the invention provides a valsartan tablet and a preparation method thereof, which solves the problem that the current valsartan tablet and its preparation method are complex, consume large man-hours, consume a large amount of manpower, and increase production costs. The content of valsartan in sartan tablets is uneven, resulting in the problems of strong side effects, low stability, safety, reliability and consistency of valsartan tablets

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