Detection device and method for judging early pregnancy time and early pregnancy abnormity

Abstract

The invention relates to a detection device for judging early pregnancy time and early pregnancy abnormity. The detection device comprises multiple test strips and a cavity for accommodating the multiple test strips, wherein the six test strips are sequentially arranged in the cavity of the detection device and used for detecting different hCG (human chorionic gonadotropin) concentrations; an hCGcritical value detected by a first test strip is 25 mIU/ml, an hCG critical value detected by a second test strip is 100 mIU/ml, an hCG critical value detected by a third test strip is 500 mIU/ml, anhCG critical value detected by a fourth test strip is 2000 mIU/ml, an hCG critical value detected by a fifth test strip is 10000 mIU/ml, and an hCG critical value detected by a sixth test strip is 25000 mIU/ml. A product is lower in detection sensitivity, larger in detection range and longer in gestational week tracking cycle, and can detect the gestational week to the ninth week. Besides, each test strip of the product can complete detection only by one detection line, a result is more direct, the process is simpler, the product is more stable, and industrialization is easier to realize.

Description

technical field [0001] The invention relates to the technical field of immune colloidal gold detection, in particular to a detection device and method for judging early pregnancy time and early pregnancy abnormality by semi-quantitative detection of human chorionic gonadotropin colloidal gold. Background technique [0002] Human chorionic gonadotropin (hCG) is a glycoprotein hormone secreted by placental chorionic cells after implantation of fertilized eggs in women [1]. It consists of α and β dimers, where the α subunit is structurally similar to the α chains of luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH), while the β chain is specific. It can enter the blood and urine through the blood circulation. [0003] hCG has the functions of FSH and LH, which can maintain the life of the menstrual corpus luteum, thereby increasing the menstrual corpus luteum to become the pregnancy corpus luteum; secondly, it has the function ...

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Problems solved by technology

[0017] CN204359798U discloses a kind of early pregnancy detection test strip, utilizes double antibody sandwich and immunochromatography principle, utilizes α-hCG monoclonal antibody, β-hCG monoclonal antibody, f-α-hCG monoclonal antibody, f-β-hCG monoclonal antibody The cloned antibody can qualitatively detect hCG and free β-hCG at the same time to diagnose pregnancy (sensitivity 25mIU/ml), it can only determine pregnancy, but not pregnancy status

[0018] CN205749530U discloses a kind of semi-quantitative test early pregnancy colloidal gold test paper and test kit, utilize double antibody sandwich and immunochromatography principle, only use a pair of antibodies, process the α-hCG monoclonal antibody and β on 2 test strips - hCG monoclonal antibody detects different concentrations (25, 100, 300, 1000mIU/ml) of human chorionic gonadotropin, so as to estimate the number of early pregnancy weeks, but its sensitivity is too high, it can only be monitored until the 6th week of pregnancy, and cannot be measured high hormone levels

[0019] CN106932598A discloses a colloidal gold test paper and kit for semi-quantitative testing of early pregnancy, using double-antibody sandwich and immunochromatography principles, only using a pair of antibodies, and processing the α-hCG monoclonal antibody on two test strips, β -hCG monoclonal antibody and free β antibody detect different concentrations of human chorionic gonadotropin, and ju

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