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Forked mixer and method of use and manufacture thereof

A technology of mixer and bifurcation, which is applied in the direction of mixing methods, chemical instruments and methods, fluid mixers, etc., and can solve problems such as difficult manufacturing of tools

Active Publication Date: 2022-02-25
THE UNIV OF BRITISH COLUMBIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such a device would require <50 μm structures, which would be difficult to fabricate using tools traditionally used to process injection molding tools, the preferred method for large-scale production of plastic microfluidic devices.

Method used

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  • Forked mixer and method of use and manufacture thereof
  • Forked mixer and method of use and manufacture thereof
  • Forked mixer and method of use and manufacture thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0178] Example 1: DVBM device tests and results

[0179] A device with two fluid inlets and one outlet was fabricated for testing. Four different designs were tested. These four designs are summarized in Table 1 below. In the case of mixer types 1-3, the impedance imbalance is established by varying the width on both sides of the ring ( image 3 ). DVBM achieves impedance imbalance by varying the path length through the loop. All test devices have inlet channels of width 140 μm and height 105 μm (hydrodynamic diameter 120 μm; impedance / length*viscosity is approximately: 6.9*10^-5 / um^4).

[0180] Table 1: Construction of various microfluidic mixer designs

[0181]

[0182] To optimize performance, a set of four exemplary DVBM mixer prototypes were fabricated with offset angles of 120°, 140°, 160° and 180°. The mixing velocity was optically measured for a range of flow rates ( Figure 7 ). From this test it was determined that the skew angle is a parameter to improv...

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Abstract

Disclosed herein are fluid mixers having bifurcated fluid flow through an annular mixing element. The mixer is operated at least partially by a Dean vortex. Accordingly, this mixer is known as a Dean Vortex Bifurcated Mixer ("DVBM"). DVBM utilizes Dean vortices and asymmetric bifurcations of the fluidic channels forming the mixer to achieve the goal of optimizing microfluidic mixing. The disclosed DVBM mixer can be incorporated into any fluidic (eg microfluidic) device known to those skilled in the art in which it is desired to mix two or more fluids. The disclosed mixers can be combined with any fluidic element known to those skilled in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, meters, detectors, and the like.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Application No. 62 / 275,630, filed January 6, 2016, the entire disclosure of which is incorporated herein by reference. Background technique [0003] Recent developments have seen high performance microfluidic mixers for the manufacture of nanoparticles at industrially relevant flow rates (eg, 10-12 mL / min). While these mixers have found widespread adoption in the drug discovery market, currently used mixers are difficult to manufacture and have certain performance limitations. At the same time, there is a market for mixers that can work with smaller volumes (on the order of a hundred microliters). The high flow rates required to run existing mixers, as well as volume losses, make them unsuitable for this application. One solution would be to miniaturize existing technologies such as interleaved herringbone mixers (SHM) with smaller dimensions. However, such a device would requ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F25/51B01F23/41
CPCB01F2215/0422B01F2215/0431B01F2215/0459B01F25/43231B01F33/30B01F25/43172B01F25/4338B01F25/433B01F25/432B01F25/434B01F25/4331B01F25/4317
Inventor A·维尔德T·利弗R·J·泰勒
Owner THE UNIV OF BRITISH COLUMBIA