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A surface-enhanced Raman substrate with a large-area nano-membrane structure and its preparation method

A surface-enhanced Raman and large-area technology, applied in Raman scattering, nanotechnology, instruments, etc., can solve the problems of high cost of SERS active substrate, difficulty in breaking through the micron scale, and low density of hot spots, etc. Controlling, easy control of experimental parameters, high density packing effect

Active Publication Date: 2021-03-30
YUNNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, although highly repetitive and large-area SERS active substrates can be prepared by "top-down" etching techniques such as photolithography and casting, compared with chemical self-assembly technology , there are problems such as high cost, low yield, and low density of hot spots
[0003] In summary, the problems in the prior art are: To prepare large-area ordered nanostructured films by "top-down" techniques such as photolithography, electron beam etching, sputtering or plasma deposition, and vapor deposition, on the one hand, expensive instruments are required Equipment and well-trained operating technicians; on the other hand, there are often a series of problems such as long processing time, low processing efficiency, and difficulty breaking through the micron scale
Solve the problems of high cost, low yield, and low density of hot spots in the preparation of highly repetitive and large-area SERS active substrates

Method used

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  • A surface-enhanced Raman substrate with a large-area nano-membrane structure and its preparation method
  • A surface-enhanced Raman substrate with a large-area nano-membrane structure and its preparation method
  • A surface-enhanced Raman substrate with a large-area nano-membrane structure and its preparation method

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preparation example Construction

[0025] Such as figure 1 As shown, the preparation method of the surface-enhanced Raman substrate of the large-area nano-membrane structure provided by the embodiment of the present invention includes the following steps:

[0026] S101: The glass slide modified with polylysine is used as the initial substrate, after being activated by soaking in a certain volume of nano-gold seed solution, it is placed in a certain concentration of chloroauric acid solution;

[0027] S102: Add a mixed solution of ascorbic acid and sodium citrate at a certain concentration ratio drop by drop, so that the chloroaurate ion is continuously reduced to nano-gold on the polylysine-modified glass slide and adsorbed on the glass slide to form a certain surface roughness. nanomembrane structure.

Embodiment 1

[0030] 1) Cut common polylysine-modified slides into 2*2cm with a glass knife 2 The left and right small pieces are spared.

[0031] 2) In 10 mL of 0.025 mM chloroauric acid (HAuCl 4 ) solution, add 100 μL of 1% sodium citrate solution and stir evenly, then quickly add 500 μL of 10 mM sodium borohydride (NaBH 4 ) solution, after reacting for 30 minutes, add the above-mentioned small pieces of polylysine-modified slides, and soak them overnight in a refrigerator at 6°C to promote polylysine-modified amino groups (-NH 2 ) activation and hydrophilic properties.

[0032] 3) Rinse the soaked slides with pure water and immerse them in 10mL of 10 -4 M's chloroauric acid solution. At the same time, a mixed solution of 10 mL of ascorbic acid and sodium citrate was added dropwise with a microsyringe pump, the dropping rate of the microsyringe pump was 20 mL / h, and the concentrations of ascorbic acid and sodium citrate were 0.05% and 0.025%, respectively. After the completion of the...

Embodiment 2

[0035] 1) Cut common polylysine-modified slides into 2*2cm with a glass knife 2 The left and right small pieces are spared.

[0036] 2) In 10 mL of 0.025 mM chloroauric acid (HAuCl 4 ) solution, add 100 μL of 1% sodium citrate solution and stir evenly, then quickly add 500 μL of 10 mM sodium borohydride (NaBH 4 ) solution, after reacting for 30 minutes, add the above-mentioned small pieces of polylysine-modified slides, and soak them overnight in a refrigerator at 6°C to promote polylysine-modified amino groups (-NH 2 ) activation and hydrophilic properties.

[0037] 3) Rinse the soaked slides with pure water and immerse them in 10mL of 10-4 M's chloroauric acid solution. At the same time, a mixed solution of 10 mL of ascorbic acid and sodium citrate was added dropwise with a micro-injection pump, the drip rate of the micro-injection pump was 20 mL / h, and the concentrations of ascorbic acid and sodium citrate were 0.05% and 0.025%, respectively. After the completion of the...

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Abstract

The invention belongs to the technical field of Raman scattering, and discloses a surface-enhanced Raman substrate for a large-area nanometer film structure and a preparation method. The preparation method comprises the following steps: soaking a polylysine-modified slide which is taken as an initial substrate in a golden seed solution for activation, and placing the slide in a chloroauric acid solution of a certain concentration; adding a mixed solution prepared by mixing ascorbic acid and sodium citrate according to a certain concentration proportion dropwise in order to continuously reducechloroaurate ions on the polylysine-modified slide to obtain gold atoms, and gathering and adsorbing the gold atoms on the slide to form nanometer gold particles, thereby forming a nanometer film structure of certain surface roughness. The preparation method has the advantage of low cost, easiness in operation, controllable technical process, high repeatability, stability and reliability.

Description

technical field [0001] The invention belongs to the technical field of Raman scattering, and in particular relates to a surface-enhanced Raman substrate with a large-area nano-membrane structure and a preparation method. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: Surface-enhanced Raman spectroscopy (SERS: surface-enhanced Raman scattering) technology has the characteristics of simplicity, speed, less interference, non-destructive and low cost. It has been widely and deeply used in the fields of analytical chemistry, laboratory medicine, food safety and surface science. Research. One of the keys to the application of SERS technology to the determination and analysis of substances is the preparation of substrates. How to prepare large-area, stable, repeatable, and uniform substrates has always been a hot spot and focus of research. At present, although highly repetitive and large-area SERS active substrat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65C23C18/44B82Y40/00
CPCB82Y40/00C23C18/44G01N21/658
Inventor 汤俊琪石俊生满石清欧全宏
Owner YUNNAN NORMAL UNIV
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