Antibacterial traditional Chinese medicinal composition as well as preparation method and application thereof

A technology of composition and traditional Chinese medicine, applied in the directions of antibacterial drugs, drug delivery, antifungal agents, etc., can solve problems such as drug resistance of pathogenic bacteria, and achieve the effect of strong synergistic sterilization effect and high sterilization rate

Active Publication Date: 2018-11-23
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In summary, the treatment of common pathogenic bacterial infections in patients is mostly based on the use of antibiotics. In view of the widespread use and even abuse of antibiotics, the problem of drug resistance of pathogenic bacteria is quite serious regardless of bacterial or fungal infections.

Method used

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  • Antibacterial traditional Chinese medicinal composition as well as preparation method and application thereof
  • Antibacterial traditional Chinese medicinal composition as well as preparation method and application thereof
  • Antibacterial traditional Chinese medicinal composition as well as preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0060] The antibacterial traditional Chinese medicine composition of this embodiment includes: 10 parts of rhubarb extract, 5 parts of Dendrobium officinale extract, 3 parts of Impatiens white extract, 2 parts of Coptis chinensis extract, 6 parts of cinnamon extract and 2 parts of Ainaxiang extract.

[0061] The preparation method of the antibacterial traditional Chinese medicine composition of the present embodiment is: the Chinese medicine of above-mentioned ratio is broken into the granule of 0.2-0.5mm, in the 80% (v / v) ethanol solution of 400mL respectively ultrasonic vibration 20min, then, according to the solid-liquid ratio Extract at 25°C for 30 days at a ratio of 1:4g / ml, filter, mix according to the above ratio to obtain a traditional Chinese medicine composition, and add auxiliary materials to the traditional Chinese medicine composition to prepare an antibacterial agent.

Embodiment 2

[0063] The antibacterial traditional Chinese medicine composition of this example includes: 100 parts of rhubarb extract, 50 parts of Dendrobium officinale extract, 30 parts of white impatiens flower extract, 15 parts of Coptis chinensis extract, 29 parts of cinnamon extract and 10 parts of Ainaxiang extract.

[0064] The preparation method is the same as in Example 1.

Embodiment 3

[0066] The antibacterial traditional Chinese medicine composition of this example includes: 10 parts of rhubarb extract, 5 parts of Dendrobium candidum extract, 5 parts of Impatiens flower extract, 2 parts of Coptis chinensis extract, 6 parts of cinnamon extract and 27 parts of Ainaxiang extract.

[0067] The preparation method is the same as in Example 1.

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Abstract

The invention discloses an antibacterial traditional Chinese medicinal composition as well as a preparation method and application thereof, and belongs to the technical field of antibacterial medicaments. The antibacterial traditional Chinese medicinal composition is prepared from the following components in parts by volume: 10 to 100 parts of radix et rhizoma rhei extract, 5 to 50 parts of caulisdendrobii officinalis extract, 3 to 30 parts of white garden balsam extract, 2 to 15 parts of rhizoma coptidis extract, 6 to 29 parts of cortex cinnamomi extract and 2 to 10 parts of blumea balsamifera extract. The traditional Chinese medicinal composition can effectively kill Candida albicans, has high sterilizing rate, and can kill clinical Candida albicans, clinical Escherichia coli, clinicalStaphylococcus aureus and clinical Pseudomonas aeruginosa. The components of the traditional Chinese medicinal composition have a stronger synergistic bactericidal effect.

Description

technical field [0001] The invention relates to the technical field of antibacterial drugs, in particular to an antibacterial traditional Chinese medicine composition and its preparation method and application. Background technique [0002] Bacterial / fungal infection has always been a medical problem that puzzles human beings. Due to the abuse of antibiotics, the efficacy of most antibiotics has been reduced to varying degrees after application, making the emergence of bacterial / fungal resistance far beyond imagination. There are a wide range of traditional Chinese medicine sources in my country, and the treatment of bacterial / fungal infections has the advantages of less toxic and side effects and less resistance to drugs. At present, the antibacterial research of traditional Chinese medicine has made great progress. With the deepening of the research on its antibacterial effect, a variety of anti-infective traditional Chinese medicines have been discovered one after anothe...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/8984A61P31/04A61P31/10
CPCA61K9/0014A61K36/185A61K36/28A61K36/54A61K36/708A61K36/718A61K36/8984A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor茆灿泉邹金晶李迪强王蔚郝静
OwnerSOUTHWEST JIAOTONG UNIV