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Synthesis method of azaconazole intermediate

A synthetic method and intermediate technology, applied in the field of synthesis of penconazole intermediates, can solve the problems of high price and difficult operation

Inactive Publication Date: 2018-12-04
QILU NORMAL UNIV
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  • Application Information

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Problems solved by technology

But these methods are either difficult to operate or expensive

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  • Synthesis method of azaconazole intermediate
  • Synthesis method of azaconazole intermediate
  • Synthesis method of azaconazole intermediate

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Embodiment Construction

[0102] The present invention is carried out like this, a kind of synthetic method of penconazole intermediate, mainly is the synthetic method of 2,4-dichloroacetophenone, 2-bromo-1-(2,4-dichlorophenyl) Synthetic method of ethyl ketone and synthetic method of ketal.

[0103] 2, the synthetic method of 4-dichloroacetophenone, concrete steps are:

[0104] (1) In a 250ml three-necked bottle, install a stirrer at the middle port, install a dropping funnel and a condenser tube at the two ports, install a calcium chloride drying tube at the upper end of the condenser tube, and connect a hydrogen chloride gas absorption device;

[0105] (2) Quickly weigh 20g (0.15 mol) of anhydrous aluminum trichloride powder, put it into a three-necked bottle, then add 30 ml m-dichlorobenzene, add 6 ml (0.06 mol) acetic anhydride dropwise under stirring, about 20 minutes to finish dripping;

[0106] (3) Then keep boiling slightly on the heating mantle for half an hour until no hydrogen chloride gas...

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Abstract

The invention discloses a synthesis method of an azaconazole intermediate. The synthesis method mainly comprises a synthesis method of 2,4-dichloroacetophenone, a synthesis method of 2-bromo-1-(2,4-dichlorophenyl) ethyl ketone, and a synthesis method of ketal. The preparation method has the advantages that the development of the novel azaconazole bactericide fills up a domestic blank in the field,similar derivative synthesis research based on the synthesis method is in the ascendant, and successful development and industrial implementation of various novel bactericides can be realized. The invention provides a novel azaconazole synthesis method.

Description

technical field [0001] The invention relates to the field of teconazole, in particular to a method for synthesizing a teconazole intermediate. Background technique [0002] Azaconazole (azaconazole), its structural formula is , is a new type of fungicide. The present invention uses various methods to explore and study the synthesis of penconazole. At the same time, due to the unique structure and excellent performance of the zeolite catalyst, it is also used in the synthesis of its intermediate brominated ketal. [0003] First, we use p-toluenesulfonic acid as a catalyst to prepare the intermediate bromoketal and chlorinated ketal of penconazole in benzene, benzene+butanol, toluene, and xylene respectively. We found that the yield of brominated ketals was always greater than that of chloroketals in any solvent. Among various solvents, the reaction yield in benzene+butanol is the highest whether it is brominated ketal or chlorinated ketal. [0004] The unique structure ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/46C07C45/63C07D317/16C07D405/06B01J29/08C07C49/807C07C49/80
CPCC07C45/46C07C45/63C07D317/16C07D405/06B01J29/084B01J2029/081B01J2229/16C07C49/807C07C49/80
Inventor 刘忠强
Owner QILU NORMAL UNIV
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