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A kind of synthetic method of penconazole intermediate

A synthesis method and intermediate technology, applied in the synthesis field of penconazole intermediates, can solve the problems of high price and difficult operation, and achieve the effects of convenient operation, no corrosion of equipment, and good economic benefits

Inactive Publication Date: 2022-01-18
QILU NORMAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

But these methods are either difficult to operate or expensive

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  • A kind of synthetic method of penconazole intermediate
  • A kind of synthetic method of penconazole intermediate
  • A kind of synthetic method of penconazole intermediate

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Embodiment Construction

[0103] The present invention is carried out like this, a kind of synthetic method of penconazole intermediate, mainly is the synthetic method of 2,4-dichloroacetophenone, 2-bromo-1-(2,4-dichlorophenyl) Synthetic method of ethyl ketone and synthetic method of ketal.

[0104] 2, the synthetic method of 4-dichloroacetophenone, concrete steps are:

[0105] (1) In a 250ml three-necked bottle, install a stirrer at the middle port, install a dropping funnel and a condenser tube at the two ports, install a calcium chloride drying tube at the upper end of the condenser tube, and connect a hydrogen chloride gas absorption device;

[0106] (2) Quickly weigh 20g (0.15 mol) of anhydrous aluminum trichloride powder, put it into a three-necked bottle, then add 30 ml m-dichlorobenzene, add 6 ml (0.06 mol) acetic anhydride dropwise under stirring, about 20 minutes to finish dripping;

[0107] (3) Then keep boiling slightly on the heating mantle for half an hour until no hydrogen chloride gas...

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Abstract

The invention discloses a method for synthesizing a teconazole intermediate, mainly including a method for synthesizing 2,4-dichloroacetophenone and 2-bromo-1-(2,4-dichlorophenyl)ethanone Methods and synthetic methods of ketals. The advantage of the present invention is: the successful research and development of the novel pentaconazole fungicide fills up the domestic gap, and the synthesis research of similar derivatives based on this will be in the ascendant, and the successful development and industrialization of various new fungicides, the present invention It is a novel method for synthesizing teconazole.

Description

technical field [0001] The invention relates to the field of teconazole, in particular to a method for synthesizing a teconazole intermediate. Background technique [0002] Azaconazole (azaconazole), its structural formula is , is a new type of fungicide. The present invention uses various methods to explore and study the synthesis of penconazole. At the same time, due to the unique structure and excellent performance of the zeolite catalyst, it is also used in the synthesis of its intermediate brominated ketal. [0003] First, we use p-toluenesulfonic acid as a catalyst to prepare the intermediate bromoketal and chlorinated ketal of penconazole in benzene, benzene+butanol, toluene, and xylene respectively. We found that the yield of brominated ketals was always greater than that of chloroketals in any solvent. Among various solvents, the reaction yield in benzene+butanol is the highest whether it is brominated ketal or chlorinated ketal. [0004] The unique structure ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/46C07C45/63C07D317/16C07D405/06B01J29/08C07C49/807C07C49/80
CPCC07C45/46C07C45/63C07D317/16C07D405/06B01J29/084B01J2029/081B01J2229/16C07C49/807C07C49/80
Inventor 刘忠强
Owner QILU NORMAL UNIV
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