Human umbilical cord mesenchymal stem cell anti-rheumatic arthritis treatment method

Abstract

The invention relates to a human umbilical cord mesenchymal stem cell preparation for treatment of rheumatoid arthritis; the human umbilical cord mesenchymal stem cell preparation includes mesenchymalstem cells, human albumin and NS. The mesenchymal stem cells are combined with the human albumin and the NS, so the release of inflammatory media is prevented while the pain of patients can be alleviated, inflammation reaction is alleviated, and thus the weight of the patients is significantly increased. At the same time, the CD4+ / CD8+ ratio can be increased according to different extents, and the levels of TNF-alpha and IL-6 in serum can be reduced.

Description

technical field [0001] The invention relates to the field of cell engineering, in particular to a human umbilical cord mesenchymal stem cell anti-rheumatoid arthritis injection and a preparation method thereof. Background technique [0002] Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic erosive arthritis characterized by symmetrical, persistent swelling and pain in the affected joints, often accompanied by morning stiffness. Rheumatoid arthritis is characterized by synovitis as a pathological change, which can cause destruction of articular cartilage and bone, and eventually lead to joint deformity, which brings great pain to patients physically and mentally. Traditional drugs for the clinical treatment of rheumatoid arthritis include non-steroidal anti-inflammatory drugs, glucocorticoids and immunosuppressants. The combined application of these drugs can alleviate the condition of rheumatoid arthritis, but long-term use of these drugs has sid...

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Problems solved by technology

But at the same time, we also noticed that due to the wide variety of cytokines involved in rheumatoid arthritis, it is not yet clear which cytokine plays a major role in the occurrence of rheumatoid arthritis, so drugs developed based on a single cytokine target are still It has treatment limitations, which suggests that scientists should integrate multiple targets for the development of rheumatoid drugs, and treat rheumatoid arthritis by regulating the overall immune level of the body.

[0004] With the advancement of modern medical technology, many diseases have been effectively treated one after another, which has significantly extended human life expectancy and greatly improved the quality of life. However, we also realize that the current level of medical technology is still unable to treat chronic diseases, autoimmune diseases, and tumors. The discovery of stem cells and the emergence of regenerative medicine technology are expected to obtain the key to the treatment of these diseases

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