Human umbilical cord mesenchymal stem cell anti-rheumatic arthritis treatment method

A stem cell, rheumatoid technology, applied in the field of cell engineering, can solve the problems that cannot be cured by treatment, and achieve the effect of reducing levels, preventing release, and weight gain

Inactive Publication Date: 2018-12-07
海南和泽生物科技有限公司
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Problems solved by technology

But at the same time, we also noticed that due to the wide variety of cytokines involved in rheumatoid arthritis, it is not yet clear which cytokine plays a major role in the occurrence of rheumatoid arthritis, so drugs developed based on a single cytokine target are still It has treatment limitations, which suggests that scientists should integrate multiple targets for the development of rheumatoid drugs, and treat rheumatoid arthritis by regulating the overall immune level of the body.
[0004] Wi

Method used

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  • Human umbilical cord mesenchymal stem cell anti-rheumatic arthritis treatment method
  • Human umbilical cord mesenchymal stem cell anti-rheumatic arthritis treatment method
  • Human umbilical cord mesenchymal stem cell anti-rheumatic arthritis treatment method

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[0022] The preparation process of the human umbilical cord mesenchymal stem cell preparation for anti-rheumatoid arthritis is as follows:

[0023] Obtain human umbilical cord mesenchymal stem cells;

[0024] Use P6 generation stem cells;

[0025] 1*10 7 Human umbilical cord mesenchymal stem cells of the P6 generation are supplemented with human albumin, with a mass fraction of 2%;

[0026] Add NS to the obtained cell suspension and quantify to 20 mL;

[0027] The human umbilical cord mesenchymal stem cell preparation for treating rheumatoid arthritis provided by the present invention is obtained.

[0028] In order to further verify the effect of the human umbilical cord mesenchymal stem cell preparation provided by the present invention in treating rheumatoid arthritis, the following experiments are set up for verification.

[0029] Experimental animals: SPF DBA / 1 mice, male and female, 7-8 weeks old, weighing 18±3g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co....

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Abstract

The invention relates to a human umbilical cord mesenchymal stem cell preparation for treatment of rheumatoid arthritis; the human umbilical cord mesenchymal stem cell preparation includes mesenchymalstem cells, human albumin and NS. The mesenchymal stem cells are combined with the human albumin and the NS, so the release of inflammatory media is prevented while the pain of patients can be alleviated, inflammation reaction is alleviated, and thus the weight of the patients is significantly increased. At the same time, the CD4+/CD8+ ratio can be increased according to different extents, and the levels of TNF-alpha and IL-6 in serum can be reduced.

Description

technical field [0001] The invention relates to the field of cell engineering, in particular to a human umbilical cord mesenchymal stem cell anti-rheumatoid arthritis injection and a preparation method thereof. Background technique [0002] Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic erosive arthritis characterized by symmetrical, persistent swelling and pain in the affected joints, often accompanied by morning stiffness. Rheumatoid arthritis is characterized by synovitis as a pathological change, which can cause destruction of articular cartilage and bone, and eventually lead to joint deformity, which brings great pain to patients physically and mentally. Traditional drugs for the clinical treatment of rheumatoid arthritis include non-steroidal anti-inflammatory drugs, glucocorticoids and immunosuppressants. The combined application of these drugs can alleviate the condition of rheumatoid arthritis, but long-term use of these drugs has sid...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61K38/38A61P29/00A61P19/02
CPCA61K35/28A61K38/385A61K2300/00
Inventor 黄佩龙秦秀兵吉海杰
Owner 海南和泽生物科技有限公司
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