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Application of caffeic acid 3,4-dyhydroxy phenethyl ester to preparing medicine for preventing colorectal cancer

A technology for hydroxyphenethyl ester and colorectal cancer, which is applied in the field of preparation of colorectal cancer prevention drugs, caffeic acid 3,4-dihydroxyphenethyl ester, can solve the problems of vaccines or drugs without colorectal cancer, etc.

Inactive Publication Date: 2018-12-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are currently no vaccines or drugs approved to prevent colorectal cancer

Method used

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  • Application of caffeic acid 3,4-dyhydroxy phenethyl ester to preparing medicine for preventing colorectal cancer
  • Application of caffeic acid 3,4-dyhydroxy phenethyl ester to preparing medicine for preventing colorectal cancer
  • Application of caffeic acid 3,4-dyhydroxy phenethyl ester to preparing medicine for preventing colorectal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1. Preventive effect of caffeic acid 3,4-dihydroxyphenethyl ester (CADPE) on DMH / DSS-induced primary colorectal cancer

[0026] In this study, 1,2-dimethylhydrazine (DMH, 20 mg / kg) was injected intraperitoneally once, and then 2% dextran sodium sulfate (dextran sodium sulfate, DSS, 36000-50000 mg / kg) was given continuously for one week. ), to induce a colorectal cancer model in ICR male mice. Observation of the preventive effect of caffeic acid 3,4-dihydroxyphenethyl ester on cancer inducer-induced colorectal carcinogenesis. The colorectal cancer model is initiated by 1,2-dimethylhydrazine (DMH), and dextran sodium sulfate (DSS) induces inflammation to promote the formation of colorectal cancer, which is similar to the process of human inflammatory colorectal cancer formation, It is an internationally recognized intestinal cancer model.

[0027] In order to find out the main links of CADPE in the prevention of colorectal cancer, this experiment designed drugs ...

Embodiment 2

[0065] Example 2. The mechanism of caffeic acid 3,4-dihydroxyphenylethyl ester (CADPE) in preventing primary colorectal cancer

[0066] The above studies show that CADPE can prevent the occurrence of primary colorectal cancer and delay the progression of primary colorectal cancer, and its action process mainly occurs in the early stage. This is different from the effect of aspirin. Aspirin's main action stage is in the later stage, while the early stage is ineffective. The mechanism by which CADPE is used to prevent primary colorectal cancer is unclear. Here we mainly discuss the mechanism of CPDPE in preventing the occurrence of primary colorectal cancer and its mechanism of delaying the progression of primary colorectal cancer.

[0067] In order to explore the early mechanism of the preventive effect of CADPE on the colorectum, we sacrificed the animals in batches by dislocation on the 1st day (the 15th day of the whole experiment) and the 4th day (the 18th day of the whole...

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Abstract

The invention provides application of caffeic acid 3,4-dyhydroxy phenethyl ester (CADPE) to preparing a medicine for preventing colorectal cancer. The medicine is prepared from CADPE as an active component and a pharmaceutically acceptable carrier. The CAPDE is capable of effectively preventing early-stage occurrence of ICR (Institute for Cancer Research) mouse colorectal cancer induced by 1,2-dimethylhydrazine (DMH) and dextran sulphate sodium salt, has no conspicuous toxicity, and has the function mechanisms of inhibiting inflammatory cell invasion and infiltration and inhibiting NF-KappaB expression in monocyte, inhibiting expression of beta-catenin in aberrant crypt, reducing expression of cell proliferin PCNA and Cyclin D1, an anti-apoptoasis protein surviving and a cancer gene c-Myc,and inhibiting tumor vessel proliferation. Novel treatment means are provided for clinical prevention and treatment on colorectal cancer.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical use of caffeic acid 3,4-dihydroxyphenethyl ester (Caffeic acid 3,4-dihydroxyphenethyl ester, CADPE), in particular to the preparation and prevention of caffeic acid 3,4-dihydroxyphenethyl ester Use in colorectal cancer medicine. More specifically, a drug containing 3,4-dihydroxyphenethyl caffeic acid as an active ingredient or one of the active ingredients is prepared for the prevention of colorectal cancer. Background technique [0002] Colorectal cancer (CRC) is the third most common cancer in the world and one of the leading causes of cancer death. With the increasing westernization of people's life, the deterioration of environmental factors, the aggravation of obesity and aging society and other factors, the incidence and mortality of colorectal cancer will further increase, so the prevention and treatment of colorectal cancer has attracted more and more attention. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P35/00
Inventor 连晓媛张治针周倩谢昕
Owner ZHEJIANG UNIV
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