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Application of butyphthalide in preparation of xerophthalmia treating drugs

A technology of butylphthalide, dry eye syndrome, applied in the field of medicine

Inactive Publication Date: 2019-01-04
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report research on the application of butylphthalide in alleviating dry eye syndrome and its preparations. The present invention provides the application of butylphthalide in the preparation of medicines for treating dry eye syndrome, which provides a new idea for the treatment of dry eye syndrome and provides The development and application of butylphthalide provides a new field

Method used

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  • Application of butyphthalide in preparation of xerophthalmia treating drugs
  • Application of butyphthalide in preparation of xerophthalmia treating drugs
  • Application of butyphthalide in preparation of xerophthalmia treating drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0014]

[0015] Take the prescribed amount of polyoxyethylene castor oil, sodium chloride and benzalkonium chloride and add it to 80 g of hot water for injection, stir until dissolved; add butylphthalide to the above solution, stir until dissolved, add water to a total of 100 g. Filter, sterilize by autoclaving for 15 minutes, and subpackage to obtain butylphthalide eye drops.

Embodiment 2

[0017]

[0018] Add polyethylene glycol 15 hydroxystearate, sodium chloride and benzalkonium chloride in 80g hot water for injection into the prescription amount, stir until dissolved; add butylphthalide to the above solution, stir until dissolved, add water to total Amount 100g. Filter, sterilize by autoclaving for 15 minutes, and subpackage to obtain butylphthalide eye drops.

Embodiment 3

[0020]

[0021] Take the prescribed amount of γ-cyclodextrin, sodium chloride and benzalkonium chloride and add it to 80 g of hot water for injection, stir until dissolved; add butylphthalide to the above solution, stir until there is no oil, add water to a total of 100 g. Sterilize by autoclaving for 15 minutes, and pack separately to obtain butylphthalide eye drops.

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Abstract

The invention provides medical application of butyphthalide and relates to application of butyphthalide in preparation of xerophthalmia treating drugs.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical use of a compound butylphthalide, in particular to the application of a compound butylphthalide as an active ingredient in the preparation of a medicine for treating dry eye syndrome. Background technique [0002] Dry eye syndrome refers to the general term for various diseases caused by abnormal tear quality or quantity or abnormal dynamics caused by any reason, resulting in decreased tear film stability, accompanied by ocular discomfort and / or ocular surface tissue lesions, which can cause Keratoconjunctivitis and can affect vision. In recent years, with the widespread use of computers and smart phones, people spend more time using their eyes, coupled with the influence of bad eye habits, resulting in a significant increase in the incidence of dry eye syndrome. Dry eye has become a global epidemic, and the incidence of dry eye in my country is gradually increasing and tends t...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P27/04
CPCA61K31/365A61P27/04
Inventor 孙勇军吕晓倩陈玺彭姣候丽蓓陈若莹张福云李晨晨赵凯高子彬
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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