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Method for preparing mulberry and chrysanthemum granule thick paste

The technology of Xiasangju and thick ointment is applied in the field of preparation of Xiasangju granule thick ointment, which can solve the problems of low content of rosmarinic acid in the extract, achieve the effects of increasing the content of rosmarinic acid, improving the curative effect of the product, and ensuring the quality of the product

Inactive Publication Date: 2019-01-04
KANGMEI BAONING (SICHUAN) PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, in the extraction and production of Xiasangju granules, due to the difference in the amount of water added, the content of rosmarinic acid in the obtained extract is relatively low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] A preparation method of Xiasangju granule thick ointment, comprising:

[0022] Preparation steps: weigh the decoction pieces of Prunella vulgaris, the decoction pieces of mulberry leaves and the decoction pieces of wild chrysanthemum respectively, and set aside;

[0023] Extraction and concentration steps: take Prunella vulgaris decoction pieces, mulberry leaf decoction pieces, and wild chrysanthemum decoction pieces, add 9-11 times of water for the first time, boil for the first time, and filter; add 7-9 times of water for the second time, boil for the second time, and filter , combined filtrate; Concentrate to obtain concentrated solution, set aside;

[0024] Steps of alcohol precipitation, concentration, and cream collection: take the concentrate and add ethanol and stir evenly, after standing still, filter the supernatant after alcohol precipitation, then recover ethanol, and concentrate the extract after recovering ethanol to obtain a thick cream.

[0025] As a pr...

Embodiment 1

[0037] A preparation method of Xiasangju granule thick ointment, comprising:

[0038] Extraction and weighing steps of Xiasangju granule: Prunella vulgaris 500g, mulberry leaves 175g, wild chrysanthemum 80g;

[0039] Extraction and concentration steps of Xiasangju granules: take Prunella vulgaris decoction pieces, mulberry leaf decoction pieces, and wild chrysanthemum decoction pieces, add 10 times 7550ml of drinking water for the first time, control the temperature at 98°C, boil for 1.5 hours, and filter; add 8 times 6040ml of drinking water for the second time Water, control the temperature at 98°C, boil for 1.5 hours, filter, and combine the filtrates; control the concentration temperature at 80°C, concentrate to 760ml of a concentrated solution with a relative density of 1.08 and a temperature of 80°C;

[0040] The steps of alcohol precipitation, concentration and ointment collection of Xiasangju granules: take 760ml of the concentrated solution and add more than 85% ethan...

Embodiment 2

[0042] A preparation method of Xiasangju granule thick ointment, comprising:

[0043] Extraction and weighing steps of Xiasangju granule: Prunella vulgaris 500g, mulberry leaves 175g, wild chrysanthemum 80g;

[0044] Extraction and concentration steps of Xiasangju granules: take Prunella vulgaris decoction pieces, mulberry leaf decoction pieces, and wild chrysanthemum decoction pieces, add 9 times 6795ml of drinking water for the first time, control the temperature at 95°C, boil for 1.5 hours, filter; add 7 times 5285ml for drinking for the second time Water, control the temperature at 95°C, boil for 1.5 hours, filter, and combine the filtrates; control the concentration temperature at 70°C, concentrate to 680ml of concentrated solution with a relative density of 1.06 and a temperature of 80°C;

[0045] The steps of alcohol precipitation, concentration and ointment collection of Xiasangju granules: take 680ml of concentrated solution and add more than 85% ethanol to make the a...

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PUM

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Abstract

The invention discloses a method for preparing mulberry and chrysanthemum granule thick paste. The method comprises a material preparation step, wherein square-stem decoction pieces, mulberry leaf decoction pieces and wild chrysanthemum flower decoction pieces are weighed for use; a extracting and concentrating step, wherein the square-stem decoction pieces, the mulberry leaf decoction pieces andthe wild chrysanthemum flower decoction pieces are taken, water of 9-11 times is added for the first time, first boiling is carried out, filtering is carried out, water of 7-9 times is added, second boiling is carried out, filtering is carried out, the filtrate is mixed, concentration is carried out, and a concentrated solution is obtained for use; an alcohol precipitation, concentration and reduction step, wherein ethyl alcohol is added to the concentrated solution, the materials are stirred to be uniform, after standing is carried out, supernate generated after alcohol precipitation is filtered out, then ethyl alcohol is recycled, extract generated after ethyl alcohol recycling is concentrated, and the thick paste is obtained. According to the method, the content of rosmarinic acid can be increased, the product quality can be guaranteed, and the product treatment effect can be improved.

Description

technical field [0001] The invention relates to a preparation method of Xiasangju granule thick ointment. Background technique [0002] Granules are granular preparations made by combining drugs with suitable excipients, and can generally be divided into soluble granules, suspension granules and effervescent granules. Its main feature is that it can be swallowed directly, or washed into water to drink. It is more convenient to apply and carry, and the dissolution and absorption speed is faster. The ingredients of Xiasangju Granules include Prunella vulgaris, wild chrysanthemum, and mulberry leaves. The auxiliary material is sucrose powder. Function cures mainly: liver heat clearing and eyesight improving, dispelling wind and dissipating heat, removing dampness and arthralgia, resolving sores. It is used for wind-heat cold, conjunctival congestion, headache, high blood pressure, dizziness and tinnitus, sore throat, boils and swelling, and can be used as a refreshing drink....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61K9/16A61P11/00A61P27/02A61P9/12A61P11/04A61P17/02A61K36/287A61K36/536
CPCA61K9/1623A61K36/287A61K36/536A61K36/605A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P9/12A61P11/00A61P11/04A61P17/02A61P27/02A61K2300/00
Inventor 许冬瑾迟慧春冯志伟李文珍
Owner KANGMEI BAONING (SICHUAN) PHARMACEUTICAL CO LTD
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