A pharmaceutical composition for treating diarrhea and its preparation method and use

A composition and drug technology, applied in the field of drugs, can solve problems such as unseen diarrhea

Inactive Publication Date: 2019-01-18
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report that the medicine of the present invention is used for the treatment of diarrhea

Method used

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  • A pharmaceutical composition for treating diarrhea and its preparation method and use
  • A pharmaceutical composition for treating diarrhea and its preparation method and use
  • A pharmaceutical composition for treating diarrhea and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the preparation of medicine of the present invention

[0027] (1) Put 500 g of rhizome powder of Atractylodes macrocephala into a 10L round bottom flask, and add 10 times the amount of water. Atractylodes macrocephala essential oil (AMO) with a volume of 6.73 mL was collected by steam distillation.

[0028] (2) Soak 500 g of ginseng rhizome powder with 8 times the amount of 60% ethanol, heat to boil, and reflux for 2 hours, repeating 3 times. The ethanol was recovered, the concentrate was purified with D101 macroporous adsorption resin, and then eluted with 70% ethanol. The concentrate was dried at 50° C. to obtain 19.46 g of Panax ginseng total saponins (PGS).

[0029] (3) After mixing AMO and PGS, it can be used directly.

[0030] The beneficial effects of the present invention are illustrated below through test examples.

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Abstract

The invention provides a pharmaceutical composition for treating diarrhea and a preparation method and use thereof. Specifically, the pharmaceutical composition is prepared from the following raw materials in weight proportion: 400-600 parts of Atractylodes macrocephala Koidz and 400-600 parts of ginseng. The experimental results show that the pharmaceutical composition of the invention can remarkably increase the body weight, thymus and spleen index of 5-FU chemotherapy mice inhibited the pathological changes of ileocolon and alleviated diarrhea.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating diarrhea, a preparation method and application thereof. Background technique [0002] Gastrointestinal (GI) damage and dysfunction are well-known side effects of cancer chemotherapy treatments and can be debilitating and potentially life-threatening. Chemotherapy administration is frequently associated with mucositis, diarrhea (chemotherapy-induced diarrhea (CID), bacterial translocation, malabsorption, abdominal cramps, gastrointestinal bleeding, and vomiting. These side effects are structural and functional effects of the intestinal epithelium. Impaired clinical outcome, often necessitating reductions in the dose and frequency of chemotherapy, thus negatively impacting the patient's overall clinical outcome.Bowel mucositis and diarrhea can lead to severe dehydration, electrolyte imbalance, sepsis due to bacterial translocation, Card...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/284A61P1/12
CPCA61K36/258A61K36/284A61K2236/37A61P1/12A61K2300/00
Inventor 彭成王晶敖慧张世洋冯五文唐飞盛永成
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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