Mustula Vison activin B protein, preparation and applications thereof

A technology of activin and B protein, applied in the field of molecular biology, can solve the problems of space-time specific mink fecundity disorder, low life rate, no mink ACTB protein and cDNA sequence, etc., and achieve the effect of increasing research and application prospects

Active Publication Date: 2019-02-01
INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a large amount of domestic mink breeding, but the breeding level is low, especially the reproductive performance of mink, not only the litter size is small, but the li...

Method used

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  • Mustula Vison activin B protein, preparation and applications thereof
  • Mustula Vison activin B protein, preparation and applications thereof
  • Mustula Vison activin B protein, preparation and applications thereof

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[0050] 1 Materials and methods

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Abstract

The invention relates to the field of molecular biology, particularly to a Mustula Vison activin B protein, a preparation and applications thereof. According to the present invention, the activin B protein comprises two Mustula Vison activin betaB subunits; the gene sequence of the activin B protein is obtained from Mustula Vison animal through a molecular biological technology, and is expressed in vitro and purified to obtain the activin B protein with biological activity; in the prior art, the research of the activin B protein in Mustula Vison animals is less; and the gene sequence of the activin B protein is separated, and the high purity protein expression method is improved, such that the research basis and new ideas can be provided for the related research, and the research and application prospects of activin B protein are substantially improved.

Description

technical field [0001] The invention relates to the field of molecular biology, in particular to a mink activin B protein and its preparation and application. Background technique [0002] Activin (Actvin, ACT), also known as activin, is a glycoprotein hormone firstly isolated and purified from porcine follicular fluid by Vale et al. and Ling et al. It is named after the inhibition of pituitary cell secretion of follicle stimulating hormone (Follicle Stimulating Hormone, FSH), which belongs to the transforming growth factor β superfamily member. Activin is mainly synthesized and secreted by ovarian granulosa cells and placenta. Because it has the biological activity of specifically promoting the secretion and synthesis of follicle stimulating hormone by pituitary cells, it is named activin. [0003] Both ACT and INH are dimers composed of two subunits. ACT is composed of β subunits, including homodimer ACTA (βA-βA) and ACTB (βB-βB) or heterodimer ACTAB (βA-βB). The three ...

Claims

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Application Information

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IPC IPC(8): C07K14/575C12N15/16C12N15/85C12N5/10A61K38/22A61P43/00A61P37/02A61P25/00A61P19/08A61P5/28A61P5/30A61P15/08
CPCA61K38/00A61P5/28A61P5/30A61P15/08A61P19/08A61P25/00A61P37/02A61P43/00C07K14/575C12N15/85
Inventor 张宇飞王丽英许保增王士勇孟庆江朱海瑛曹新燕常彤
Owner INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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