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Application of traditional Chinese medicine composition in treating diseases caused by mucosal injury

A mucosal injury and composition technology, applied in the field of medicine, can solve the problems of unproven gastric mucosal repair effect, achieve the effect of shortening the recovery time, less toxic and side effects, and accelerating mucosal repair

Inactive Publication Date: 2019-03-12
CHONGQING TAIJI INDAL GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This invention only verified the effect of superficial gastritis, the main function is to inhibit the secretion of gastric acid to alleviate the symptoms of gastritis, and did not verify whether it has a repairing effect on gastric mucosa

Method used

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  • Application of traditional Chinese medicine composition in treating diseases caused by mucosal injury
  • Application of traditional Chinese medicine composition in treating diseases caused by mucosal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Atractylodes 80g, Chenpi 80g, Magnolia officinalis (made from ginger) 80g, Angelica dahurica 120g, Poria cocos 120g, Dabupi 120g, raw pinellia 80g, licorice extract 10g, patchouli oil 0.8ml, perilla leaf oil 0.4ml.

[0033] The Magnolia officinalis of formula quantity is refluxed and extracted with ethanol to obtain the ethanol extract of Magnolia officinalis; The atractylodes atractylodis of formula quantity, the described tangerine peel and the said Angelica dahurica are distilled and extracted with water as medium to obtain a distillation extraction mixture; The above-mentioned amount of Poria cocos is decocted with water and filtered to obtain a decoction of Poria cocos; after boiling the Poria cocos in the formula amount as a medium, it is cooled to 70-90° C. to fully infiltrate and filtered to obtain Poria cocos. Soaking solution: take the raw pinellia of the formula and fully soak it in water medium to obtain the pinellia soaking liquid; and take dried ginger equi...

experiment example 1

[0035] Experimental example 1 Human gastric mucosal epithelial cell line GES-1

[0036] 1. Experimental steps

[0037] When carrying out subculture in sub-discs, the solution (filtered and sterilized) obtained in Example 1 was added to the culture solution of experimental group 1, and the addition amount was 0.05ml / 1ml medium; Solution (filtered and sterilized), the addition amount is 0.025ml / 1ml culture medium; ultrapure water is added to the culture solution of the control group, the addition amount is 0.05ml / 1ml culture medium. The above three mediums were used to culture the human gastric mucosal epithelial cell line GES-1 cells, and the growth of the cells was observed before and after 2 days of culture, and photographed and counted.

[0038] 2. Experimental results

[0039]

[0040]

[0041] The growth of the cell number of the experimental group 1 and the experimental group 2 is significantly higher than that of the control group. Therefore, the pharmaceutical c...

experiment example 2

[0042] Experimental Example 2 Human normal colorectal mucosal cell line FHC

[0043] 1. Experimental steps

[0044] When carrying out subculture in sub-discs, the solution (filtered and sterilized) obtained in Example 1 was added to the culture solution of experimental group 1, and the addition amount was 0.05ml / 1ml medium; Solution (filtered and sterilized), the addition amount is 0.025ml / 1ml culture medium; ultrapure water is added to the culture solution of the control group, the addition amount is 0.05ml / 1ml culture medium. The above three mediums were used to culture the human normal colorectal mucosal cell line FHC cells, and the growth of the cells was observed after 2 days, and the cells were photographed and counted.

[0045] 2. Experimental results

[0046] group

[0047] The growth of the cell number of the experimental group 1 and the experimental group 2 is significantly higher than that of the control group, therefore, the pharmaceutical composition o...

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Abstract

The invention belongs to the field of medicine, and particularly relates to application of a traditional Chinese medicine composition in preparing a drug for treating diseases caused by mucosal injury. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 80 parts of rhizoma atractylodis, 80 parts of tangerine peel, 80 parts of mangnolia officinalis, 120 parts of radix angelicae dahurioae, 120 parts of poria cocos, 120 parts of areca peel, 80 parts of unprocessed rhizoma pinelliae, 10 parts of licorice root extract, 0.8 part by volume ofpatchouli oil, and 0.4 part by volume of perilla leaf oil. The traditional Chinese medicine composition of the invention adopts the traditional Chinese herbs as raw materials, is less in toxic and side effects, facilitates the proliferation of mucosal cells, and can promote the restoration of the injured mucosa. Therefore, the traditional Chinese medicine composition of the invention can be used for preparing the drug for treating the diseases caused by the mucosal injury.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating diseases caused by mucosal damage. Background technique [0002] Mucosa injury is common in daily life. Infectious diseases, allergic diseases, local irritation, etc. can all cause damage to the oral mucosa; chemical factors (smoking, drinking, drinking tea, coffee and irritating drugs such as aspirin, indomethacin, etc.), Factors such as hot, rough food or overeating, etc.), bacteria or their toxin stimulation may cause damage to the gastric mucosa; factors such as constipation may cause intestinal damage. [0003] At present, there is no effective method for repairing mucosal injury. [0004] Authorized patent CN200910260975.7 discloses a preparation for treating gastritis and gastric ulcer and protecting gastric mucosa, which uses Astragalus, Atractylodes Rhizoma Atr...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61P1/02A61P1/04A61P1/00A61P29/00A61P7/04
CPCA61K36/076A61K36/232A61K36/284A61K36/484A61K36/532A61K36/535A61K36/575A61K36/752A61K36/8888A61K36/889A61K2236/33A61K2236/331A61K2236/51A61P1/00A61P1/02A61P1/04A61P7/04A61P29/00A61K2300/00
Inventor 白礼西秦少容金思岑卿玉玲陈康覃学
Owner CHONGQING TAIJI INDAL GROUP
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