82 results about "Mucosal cell" patented technology

The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chemoprotective polyamines or amino thiols formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.

Polyamine effectors are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more polyamine effectors formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.

The present invention provides methods and compositions for inhibiting influenza infection and / or replication based on the phenomenon of RNA interference (RNAi) well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and / or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza.

A pharmaceutical composition is provided for use in the healing of cells containing about 0.0001 percent weight per volume (% w / v) to about 2% w / v of an alginic acid or a salt of alginic acid having a molecular weight in the range of greater than about 250,000 to about 1,000,000, provided that if the composition additionally contains an alginic acid or a salt of alginic acid having a molecular weight in the range of about 20,000 to about 250,000, it is present in an amount of less than 1% w / w. The use of the pharmaceutical composition for the healing cells in a mammal, preferably mucosal cells is also provided.

The invention provides compositions and methods useful for treating disorders treatable by producing a protein in a regulatable manner in a mucosal cell or tissue of an animal. The treatment methods include in vivo and ex vivo methods, including transplanting in vitro transformed cells that secrete the protein into a mammalian subject.

This invention relates to a method of producing an auto induced biological barrier against spermatozoids and / or other microorganisms including viruses and / or pre cancers or non invasive cancers involving the production of an autoimmune reaction in a host in need of such auto-inducement. The invention is characterized in that it comprises the steps of producing heat shock proteins inside vaginal and cervical mucosal cells and releasing said heat shock proteins into the vaginal cavity thus inducing an autoimmune response through a trigger and / or stimulation of both innate and adaptive systems and, as a consequence, the production of: a contraceptive effect through the elimination of the migration or free movement of individual or populations of spermatozoids and / or an inhibition of the maturation and / or capacitation process of the same and / or a neutralization or destruction of the same; a prophylactic effect through an elimination of the migration or free movement of individual or populations of other microorganisms including viruses and / or a neutralization or destruction of the same; a prophylactic effect against pre cancers; a therapeutic effect against non invasive cancers. The invention also relates to a device for using said method comprising a hollow body (1) provided with a heat source on the inside as well as with a means (13, 27) of removal of said hollow body from the vaginal or rectal cavity and a means (6, 8, 10) capable of exchanging heat originating from the hollow body.

The invention relates to a composition without hormones and antibiotics for alleviating rhinitis. A main raw material of the composition is wood vinegar liquid which is prepared from tree trunks or branches of casuarina equisetifolia. According to the composition for alleviating the rhinitis provided by the invention, the main component of the composition is the casuarina equisetifolia wood vinegar liquid; by utilizing the effects, including high sterilization, disinfection, virus killing, permeation and convergence, of the wood vinegar liquid, the effects of promoting convergence of respiratory tract epidermal mucosa cells as well as deswelling and dredging channels can be achieved, the symptoms such as nasal obstruction, much snot, reduced sense of smell, headache and dizziness can be effectively alleviated, and a good assisted rehabilitation effect on the rhinitis can be achieved. Preferably, the composition is a cream, and the cream includes ingredients such as casuarina equisetifolia secondary-distillation wood vinegar liquid, bee wax, paraffin oil, menthol, glycerol, azone, BHT, 305 emulsifying agent and Oliven1000; and the cream product wholly shows the characteristics of softness, smoothness, lightness, no greasiness, easiness for absorption and no irritability, and also has very quick and obvious effects on alleviating the rhinitis symptom of the patient.