Mucosal cytotoxic T lymphocyte responses

a technology of mucosal immune response and cytotoxic t lymphocytes, which is applied in the direction of antibody medical ingredients, dsdna viruses, peptide sources, etc., can solve the problems of inability prior investigations have failed to identify fundamental mechanisms linking immune responses to protection, and administration of antigens via parenteral routes (subcutaneously). , to achieve the effect of enhancing the ctl response, reducing
US20050232897A1Inactive Publication Date: 2005-10-20HEALTH & HUMAN SERVICES THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
HEALTH & HUMAN SERVICES THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF
Publication Date
2005-10-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides methods for induction of an antigen-specific, mucosal cytotoxic T lymphocyte response useful in preventing and treating infections with pathogens that gain entry via a mucosal surface.
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Description

RELATED APPLICATIONS

[0001] The present application is a continuation-in-part application of, and claims the benefit under Title 35 of U.S. Provisional Application Nos. 60 / 058,523 filed on Sep. 11, 1997, and 60 / 074,894 filed on Feb. 17, 1998.TECHNICAL FIELD

[0002] The present invention relates to methods and compositions for stimulating immune responses in mammals. More particularly, the invention relates to methods and compositions for stimulating mucosal immunity. BACKGROUND OF THE INVENTION

[0003] Many infectious pathogens, e.g., HIV-1, enter their mammalian hosts via a mucosal tissue prior to establishing a systemic infection. Veazey, et al., Science 280:427-431, 1998. Accordingly, vaccines capable of protecting against HIV should be capable of inducing long-term mucosal immune responses. A number of recent studies have shown that such immune responses require direct stimulation of mucosal tissues, and may be achieved with live attenuated virus, Cranage, et al., Virology 229:143...

Claims

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