Application of ciglitazone in preparing drugs for treating pulmonary arterial hypertension
A technology for pulmonary arterial hypertension and ciglitazone, applied in the field of biomedicine, can solve problems such as poor treatment effect, and achieve the effects of reducing average pulmonary artery pressure and pulmonary vascular resistance, improving pulmonary vascular remodeling, and promoting apoptosis
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[0019] 1. Materials and methods
[0020] 1.1 Establishment of Rat Pulmonary Hypertension Model
[0021] One-time subcutaneous injection of monocrotaline (Monocrotaline, MCT, 60mg / kg) was performed on the back of the neck. After 3 weeks, the pulmonary artery pressure and hemodynamic parameters were randomly measured by right heart catheterization to determine whether the model was established successfully.
[0022] 1.2 Experimental grouping and drug intervention
[0023] 50 male SPF grade SD rats (provided by the Animal Room of Shanghai Chinese Academy of Sciences), weighing 200-220g. SD rats were randomly divided into normal control group, model group, and different dose groups of ciglitazone (1 mg / kg / d, 3 mg / kg / d, 10 mg / kg / d), with 10 rats in each group. The normal control group was given normal saline (0.3ml / kg / d) by intragastric administration, and the rest of the rats in the other groups were subcutaneously injected with MCT (60mg / kg) at the back of the neck, starting fr...
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