Application of Tongxinluo in preparing medicament for treating pulmonary hypertension
A technology for treating pulmonary hypertension and drugs, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., to achieve the effects of treating pulmonary hypertension, improving remodeling, and reducing pulmonary vascular resistance
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[0011] 1. Materials and methods
[0012] 1.1 Establishment of Rat Pulmonary Hypertension Model
[0013] Male SPF grade SD rats, weighing 200-220g. One-time subcutaneous injection of monocrotaline (Monocrotaline, MCT, 40mg / kg), 3 weeks later, right heart catheterization was used randomly to measure pulmonary artery pressure and hemodynamic parameters to identify whether the model was successfully established.
[0014] 1.2 Experimental grouping and drug intervention
[0015] (1) Model group (MCT group): 10 rats were given normal saline by intragastric administration after the pulmonary hypertension model was successfully established for 3 consecutive weeks.
[0016] (2) Tongxinluo low-dose group (Tongxinluo 0.2g·kg·d group): 10 rats were given Tongxinluo by intragastric administration after the pulmonary hypertension model was successfully established for 3 consecutive weeks.
[0017] (3) Tongxinluo middle-dose group (Tongxinluo 0.4g·kg·d group): 10 rats were given Tongxinluo...
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