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Novel medicinal application of panax quinquefolius saponin

A technology of American ginseng and total saponins, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, applications, etc., can solve the problem of myocardial remodeling without total saponins from stems and leaves of American ginseng, and achieve the effect of reducing myocardial remodeling

Active Publication Date: 2019-03-29
SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current traditional Chinese medicine protection is all traditional Chinese medicine compound preparations, and there is no single active ingredient of traditional Chinese medicine that has a reliable effect on myocardial remodeling caused by weightlessness / simulated weightlessness
[0006] Xinyue Capsules, which mainly contain total saponins from stems and leaves of American ginseng, have been clinically used for more than 20 years. At present, there is no research on the application of total saponins from stems and leaves of American ginseng against weightlessness / simulated weightlessness.

Method used

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  • Novel medicinal application of panax quinquefolius saponin
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  • Novel medicinal application of panax quinquefolius saponin

Examples

Experimental program
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Effect test

Embodiment Construction

[0022] Hereinafter, the present invention will be explained more specifically through examples, but the present invention is not limited by these examples.

[0023] 1. The effect of panax quinquefolium saponins on the body weight and heart weight of myocardial remodeling rats caused by simulated weightlessness.

[0024] 1.1 Animals and experimental drugs

[0025] Choose healthy male SD rats, 4-6 weeks old, with an average weight of 150-170g; in an environment with a temperature of 22℃-26℃, and an air humidity of 45%-65%, they are divided in a breeding room with natural light and artificial light. Raised in a cage, the animals are free to eat and drink; they are adaptively fed for one week. The experimental drug, the total saponins from the stems and leaves of American ginseng (purity 99.0%) was provided by Ji'an Yisheng Pharmaceutical Co., Ltd. of Jilin Province.

[0026] 1.2 Modeling and grouping

[0027] 1.2.1 Establishment of simulated weightlessness model of rat tail suspension

[...

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Abstract

The invention belongs to the field of biological medicines and relates to a novel application of panax quinquefolius saponin, or a composition comprising the panax quinquefolius saponin, to preventionand / or treatment on cardiac remodeling due to special environments, such as aerospace. The invention is characterized by means of the total saponin, extracted from stems and leaves of American ginseng, for prevention and treatment on cardiac remodeling due to the special environments, such as aerospace, and the application of the panax quinquefolius saponin.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and relates to a new use of the American ginseng stem and leaf total saponins or a composition containing the American ginseng stem and leaf total saponins for preventing and / or treating the myocardial remodeling effect caused by special environments such as aerospace. Background technique [0002] Myocardial remodeling refers to the obvious changes in the cell structure, function, number and genetic phenotype of myocardial cells and myocardial extracellular matrix under some physiological or pathological stimulation of the heart, that is, changes in the size, shape and function of the heart . Myocardial remodeling may be physiological or pathological. Ordinary pathological myocardial remodeling (except for myocardial remodeling caused by long-term bed rest) often leads to myocardial hypertrophy. The difference is that myocardial remodeling caused by weightlessness / simulated weightlessness is caused by ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/00A61K135/00A61K127/00
CPCA23L33/105A61K36/258A23V2002/00A23V2200/30A23V2200/326A23V2250/21
Inventor 李英贤史大卓孙慧媛凌树宽李玉恒钟国徽赵定胜
Owner SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
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