Polyethylene glycol nano drug delivery system with enhanced anti-tumor effect and preparation method thereof

A nano-drug delivery system and polyethylene glycol technology, applied in the field of biomedicine, can solve the problems of unsatisfactory anti-tumor effect of chemotherapeutic drugs, tumor drug resistance restricting clinical tumor treatment, etc., to achieve enhanced anti-tumor effect and good tumor Penetration, improve the effect of distribution
CN109529048AInactive Publication Date: 2019-03-29JIANGSU VOCATIONAL COLLEGE OF MEDICINE
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU VOCATIONAL COLLEGE OF MEDICINE
Publication Date
2019-03-29
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a polyethylene glycol nano drug delivery system with enhanced anti-tumor effect and a preparation method thereof. The drug delivery system takes functionalized polyethylene glycol as a carrier molecule, a phototherapy agent as a medicament and RGD polypeptide as a target head. The system can realize the enhancement of the anti-tumor effect, mainly because the polyethyleneglycol nano drug delivery system has small particle size, has good tumor penetrability, has active tumor targeting property, and can improve the distribution of the drugs in tumors so as to reach thetreatment concentration.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a polyethylene glycol nano drug delivery system with enhanced anti-tumor effect and a preparation method. Background technique

[0002] Cancer is a major disease that endangers human health, and its incidence is increasing year by year. Although some substantial progress has been made in the treatment of cancer in the past few decades, the antitumor effect of chemotherapy drugs is still unsatisfactory, and the generation of tumor drug resistance is the main obstacle restricting clinical tumor treatment.

[0003] The structure of tumor tissue is complex, and a series of physical and physiological barriers inside make it difficult for chemotherapy drugs to penetrate the tumor and reach the inside of the tumor tissue, making tumor cells withstand sublethal doses of drug stimulation for a long time, which is an important reason for tumor drug resistance one. Therefore, delivering a suffi...

Claims

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