Multichannel tumor marker parallel detection sensor and use method thereof

A tumor marker and detection sensor technology, which is applied in the field of multi-channel tumor marker parallel detection sensors, can solve the problems of low detection efficiency, multiple forms of single molecules passing through nanopores, and reduced detection accuracy, so as to achieve a simple and easy-to-use detection method. The method is simple and the effect of improving the detection efficiency
CN109541210AActive Publication Date: 2019-03-29GUANGDONG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGDONG UNIV OF TECH
Publication Date
2019-03-29

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Abstract

A multifunctional tumor marker parallel detection sensor and a use method thereof relate to the field of micro-nano medical detection application technology. A plurality of nano-hole sandwich array chips are supplied as a substrate. One side, which is next to a waste liquid outlet, of each liquid pool of a base is provided with a plurality of flow channels. Each flow channel is communicated with aliquid pool. Each liquid pool of the base is provided with a chip. Each liquid pool is bonded with a PDMS cover board. The nano-hole sandwich array chips are respectively placed at the central part of each liquid pool of the base flatly. Penetration of liquid at the upper side and the lower side of each liquid pool can only be realized through the nano-hole array. Then the inner surface of the middle-layer nano-hole of the substrate of each channel is modified by tumor marker antibody modules. Then a testing sample is conveyed to a testing area by a precise injection pump through each channel. Parallel detection for a plurality of tumor markers is performed. Tumor marker modules are captured by the antibody modules in the nano-hole sandwich array chip, and furthermore blocking current isgenerated. Concentration determining of the tumor marker is realized according to the reduction amplitude of the blocking current.
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Description

technical field

[0001] The invention relates to the technical field of biosensors, in particular to a multi-channel tumor marker parallel detection sensor and its application method. Background technique

[0002] Cancer is the second leading cause of human death, and new cancer cases in my country account for about 1 / 4 of the world's total. The World Health Organization points out that 1 / 3 of cancers can be cured in time through early diagnosis. Tumor markers are substances produced directly by tumor cells or induced by non-tumor cells through tumor cells. Studies have shown that when tumors develop, the concentration of markers is significantly abnormal, indicating the presence of tumors. Tumor marker detection research provides new ideas for non-invasive early diagnosis of cancer. Quantitative detection of tumor markers using micro-nano sensors with special effects such as Coulomb blockade and quantum size effects has also become a major research method for early diagno...

Claims

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