107 results about "Nanohole array" patented technology

The invention discloses a nano-diamond array preparation and miRNA ultra-sensitive detection method, and the nano-diamond array preparation comprises the following steps: self-assembling densely arranged single-layer polystyrene (PS) microsphere templates on a silicon wafer plated with a gold film, and thinning the particle size of PS microspheres by adopting a reactive ion etching process to obtain non-densely arranged PS microsphere templates; carrying out thermal evaporation on an aluminum film and ultrasonically removing the PS microspheres to obtain a micropore array; then modifying the surface of the nano-diamond containing the NV color center with a single-chain DNA probe, and self-assembling the diamond modified by the DNA probe to the nano-pore array through a gold-sulfur bond; the miRNA detection comprises the following steps: firstly, preparing a target miRNA coupled probe magnetic sphere, dropwise adding the target miRNA coupled probe magnetic sphere to the nano-diamond array, then scanning the target miRNA coupled probe magnetic sphere on the surface of the nano-diamond array through the scanning system, the microwave module and the optical path system, and collecting an optical detection magnetic resonance spectrum. The invention is expected to be applied to the field of early diagnosis of cancers.

A THz-band TM polarization double-band tunable spectrum selective absorber comprises a graphene single layer, a square nanopore array, a dielectric medium thin film layer, an antireflection thin film layer and a dielectric medium substrate from top to bottom, the square nanopore array is composed of two-dimensional periodic nanopore arrays, and when TM polarized light is vertically incident, the two-dimensional periodic nanopore arrays form a two-dimensional periodic nanopore array; incident light in two narrow frequency ranges will be absorbed, along with changes of structure parameters and incident angles, small frequency shift of absorption spectrum occurs, small change of peak absorption efficiency occurs accordingly, absorption higher than 50% can be always kept at each peak frequency, and the full width at half maximum of an absorption spectrum line is always smaller than 0.005 THz. Dynamic tuning is carried out in a large frequency range by changing the Fermi level of graphene. The device is processed by combining an electron beam direct writing device with a microelectronic deep etching process, can be produced in batches, and has an important practical prospect.

The invention discloses a molecularly imprinted gold nanopore array substrate for single exosome capture-in-situ Raman detection as well as a preparation method and application of the molecularly imprinted gold nanopore array substrate, and belongs to the technical field of biological detection. The molecularly imprinted gold nanopore array substrate structurally comprises a base material and a nanogold layer from bottom to top, the nanogold layer comprises sunken gold nanopores which are distributed in an array mode, the bottoms of the gold nanopores are provided with modified gold nanoparticles, the gold nanopores comprise imprinted cavities matched with exosomes, the size of each gold nanopore is matched with the size of a single exosome, and the size of each imprinted cavity is matched with the size of the corresponding exosome. The gold nanopore channels distributed in the array form a gap between single exosomes, and the gap is greater than or equal to 1 mu m. According to the invention, a gold nanopore channel can be accurately regulated and controlled, and an exosome molecular imprinting structure is modified in the pore channel, so that capture and detection of a single exosome in body fluid are realized; a good adsorption effect on urine exosomes is achieved, and the adsorbed exosomes can be efficiently captured through the nano pore channels; and the nanopore enhancement factor is as high as 7.27 * 10 < 5 >.

The invention belongs to the technical field of biological material surface modification, and discloses a medical titanium alloy surface multistage bionic composite coating and a preparation method thereof. According to the method, the medical titanium alloy is sequentially subjected to micro-arc oxidation and anodic oxidation, and the multi-stage bionic composite coating is obtained. The purpose of micro-arc oxidation is to prepare a micron porous coating, the purpose of anodic oxidation is to perform random breakdown on the surface of the micro-arc oxidation coating, a micron honeycomb-shaped pit array is further prepared, and nano-pore arrays are uniformly distributed in pits. The multi-stage bionic composite coating has the micro-nano bionic characteristic, and the biological function is further improved by preparing a series of depth-adjustable honeycomb-shaped pits and nano-pore arrays in the pits while the mechanical anchoring effect of a micron porous structure on new bone tissue is kept. Moreover, the structure has mechanical stability, so that the damage to the nano structure can be avoided when the nano structure is damaged by external force, and the structure and the function of the nano structure are still not lost.

The invention relates to a local polarization enhanced nonlinear ionization nanometer inscribing system and method, and belongs to the technical field of femtosecond laser processing. The nanometer inscribing method has the large-area machining capacity, a large-area nanometer hole array can be machined in a material in a flying dotting mode, and the distance between adjacent points in the nanometer hole array can be controlled by controlling the speed of a high-precision displacement table and the repetition frequency of femtosecond laser pulses; the size of the nanopore can be controlled by controlling the pulse energy; the characteristic line width of the nanowire can be controlled by controlling the pulse energy and the speed of the high-precision displacement table; patterns are designed, and a high-precision displacement table is introduced, so that patterning processing of nanowires can be realized.

The invention provides a multifunctional surface enhanced Raman scattering chip realized based on double Fano resonance. The multifunctional surface enhanced Raman scattering chip comprises a three-layer structure film system formed by a periodic gold nanopore array, a gold nanodisk array and photoresist. The multifunctional surface enhanced Raman scattering chip can form independent double Fano resonance and is used for enhancing Raman excitation light and Raman Stokes light at the same time. The invention also provides a regulation and control method of the multifunctional surface enhanced Raman scattering chip. By regulating and controlling the diameter of the gold nanopore, the first Fano resonance of the double Fano resonance is not influenced by tuning parameters and the refractive index change of a culture solution, the excitation light enhancement is stably realized, and the broadband enhancement tuning of the second Fano resonance is realized at the same time. The multifunctional surface-enhanced Raman scattering chip has the functions of low light heat, tunable enhancement of broadband and insensitivity to background refractive index, and is very suitable for in-situ detection of Raman signals of living cells in a culture solution.

The application relates to a local polarization enhanced nonlinear ionization nanolithography system and method, and belongs to the technical field of femtosecond laser processing. The nanolithography method has the capability of large-area processing, can process a large-area nanohole array on a material through a 'flying dotting' mode, can control the distance between adjacent points in the nanohole array by controlling the speed of a high-precision displacement table and the repetition frequency of femtosecond laser pulses, can control the size of the nanohole by controlling the pulse energy, can control the characteristic line width of a nanowire by controlling the pulse energy and the speed of the high-precision displacement table, and can realize the patterning processing of the nanowire by designing a pattern and introducing the high-precision displacement table.

The present invention discloses an experimental device and method for induced polarization of a nanopore array simulating rock and soil pore structure, and relates to the technical field of electrical prospecting experiments. It comprises an experimental container, wherein a cavity is arranged in the experimental container, power supply electrodes are arranged at both ends of the cavity, a solid nanoplate is arranged in the middle of the cavity, and the space between the power supply electrode and the solid nanoplate is used to accommodate an electrolyte solution; a plurality of nanopores are arranged on the solid nanoplate, and the power supply electrode is used to apply a direct current electric field to the electrolyte solution, so that the ions in the electrolyte solution move in a directional manner from the nanopores to produce a polarization effect. The present invention studies the induced polarization effect in solid nanopores through experiments, reveals its microscopic mechanism, establishes a quantitative model, and explores the main factors and response laws that affect the induced polarization effect.

The invention relates to the technical field of biosensors, and particularly discloses a preparation method of a multi-channel solid nanopore array. The method comprises the following steps: respectively constructing a group of parallel and independent micro-channels on the front and back surfaces of a chip prepared with a suspended dielectric film window array, enabling the micro-channels on the two surfaces to be orthogonally arranged in space, integrating an independent electrode in each micro-channel, and injecting electrolyte; the electrodes of the micro-channel on one side and the electrodes of the micro-channel on the other side are selectively connected through an external control circuit, namely controllable electric fields can be established on the two sides of the thin film window at the unique intersection point corresponding to the electrodes, so that addressing and selective dielectric breakdown of the window are achieved, all the windows on the whole chip are automatically and sequentially addressed, traversed and processed, and the yield of the chip is improved. And forming a nanopore array. By means of the method, a large number of nanopore arrays can be controllably manufactured on a single chip at a time, and nanopore array machining with high throughput, low cost and high consistency is achieved.

Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic / polaritonic structures allow for single base resolution using optical techniques.

A molecular sensing device and molecular sensing method that are based on quantum plexcitonic states on strongly coupled nanophotonic systems are disclosed. The molecular sensing device includes a metasurface, a layer of a semiconducting and / or dielectric material disposed onto a layer of electrically conducting material, a metal nanohole array disposed onto the metasurface, a biological recognition element disposed onto a surface of the metal nanohole array, and where the surface of the metal nanohole array is configured to receive a bioanalyte and a plurality of quantum emitters. The molecular sensing device can be a mixture of quantum emitters, comprising gold, having more than one aspect ratio. The molecular sensing device may include a spectroscopic instrument, including a portable detector. The one or more biological recognition elements are configured to recognize a communicable disease in response to the presence of a specific biological recognition element.

The invention relates to the technical field of surface plasma photonics and micro-nano optical sensing, in particular to a porous super-structure plasma sensor and a preparation method and application thereof.The porous super-structure plasma sensor comprises a substrate, and a first metal layer, a first silicon dioxide layer, a second metal layer and a second silicon dioxide layer are sequentially arranged on the substrate; a plurality of nanopore arrays are arranged on the porous superstructure plasma sensor; and the nanopore array penetrates through the first silicon dioxide layer, the second metal layer and the second silicon dioxide layer. Through the synergistic effect of a metal-medium-metal-medium (such as gold / silicon dioxide / gold / silicon dioxide) multi-layer structure and the periodic nanopore array, strong surface plasmon resonance is excited in a visible light-near infrared band, perfect combination of high absorptivity, high sensitivity and high FOM value is realized, and the sensor can be used for gas concentration change detection, and can be applied to detection of gas concentration changes. The problem that an existing plasmon sensor cannot meet the working requirement of the visible light-near infrared band is solved.

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.

The application discloses a pretreatment cleaning agent processing control system and method, relates to the technical field of processing control, and injects a light-controlled origami probe solution into a nano-pore array of a piezoelectric ceramic chip, uses an AFM probe to apply an axial force to activate an origami structure, records a curve of force change with AFM probe displacement in real time, extracts folding displacement of a folding state area and complete unfolding displacement of a complete unfolding area, integrates and calculates the curve to obtain processing free energy, compares the processing free energy with a free energy range of high-quality cleaning agent finished products in a preset database, and if the processing free energy falls within the range, it is determined that current process parameters are in a reasonable interval, the parameters are maintained, and an efficiency label is marked as 1, and if the processing free energy exceeds the range, it is determined that the process is abnormal, an efficiency label is marked as 0, and dynamic adjustment is triggered. The control method not only improves the precision and efficiency of cleaning agent processing, but also reduces the rate of defective products and production loss, and provides key technical support for large-scale and stable production of high-quality cleaning agents.

The invention discloses a preparation method and application of a silicon nanopore array, and relates to the field of nanopore array manufacturing. The method comprises the following steps: taking an AAO film as a nano template, and transferring the AAO film to the surface of a silicon substrate; depositing a silver nanoparticle array on the AAO thin film to form large-area ordered silver nanoparticle arrangement; and removing the AAO thin film to obtain a silver nanoparticle array on the silicon substrate, immersing the silicon substrate containing silver nanoparticles into an etching solution for reaction, and forming the silicon nanopore array by taking the silver nanoparticles as a metal catalyst. Compared with the prior art, the method has the advantages that the geometrical shape of the nanopore can be accurately controlled, and the method has the characteristics of low cost, high adaptability and repeatability and is suitable for large-scale production to meet diversified requirements in different fields.

The invention relates to a funnel diode realized based on a nanopore modified dielectric polymer molecule monolayer, and relates to the technical field of semiconductor devices. The preparation method of the funnel diode comprises the following steps: forming a three-layer PVP dielectric film through bi-crosslinking treatment, and constructing a nanopore array on the surface of the three-layer PVP dielectric film by using a soft nanoimprint technology to form a polymer nano dielectric layer; sequentially depositing an organic semiconductor layer and a top electrode to complete a diode main body structure; and finally, integrating a molecular memory monolayer formed by gold nanoclusters or copper stearate. The device is compact in structure, the unidirectional convergence of current carriers is realized by utilizing a funnel effect generated by the nanopores, and the device has the characteristics of high-voltage rectification ratio and ultralow working voltage under the coordination of a single molecular layer, and has nonvolatile storage and synaptic plasticity.

The invention discloses a reversible dynamic aperture solid nanopore array based on a temperature-sensitive phase change layer and a preparation method and application of the reversible dynamic aperture solid nanopore array, and belongs to the technical field of single molecule detection and nanostructure regulation, the array introduces the temperature-sensitive phase change layer into the inner wall of a solid nanopore, and when the local temperature crosses the phase transition point of the temperature-sensitive phase change layer, reversible volume change is generated; therefore, the effective aperture of the nanopore is continuously adjustable in a sub-nanometer scale range. An independent micro heating unit and an independent temperature sensing unit are integrated below each nanopore in the array, and single-pore-level accurate temperature control adjustment is achieved in a row-column addressing mode. In combination with ionic current monitoring and an external control module, the aperture can be set in real time according to the size requirements of different target molecules, and dynamic aperture regulation and control with a programmable structure, quick response and good repeatability are realized. The array structure provided by the invention is suitable for single molecule level detection of objects such as multiple types of small molecule pollutants, tumor-related biomarkers, biomacromolecules and the like, and has the advantages of high sensitivity, high flux and wide applicability.

The invention discloses a high-sensitivity optical biochip based on an AAO and ZIF-8 composite structure and a preparation and detection method thereof, and relates to the technical field of optical biochip detection. The preparation method comprises the following steps: coating the surface of nanopore aluminum oxide with ZIF-8 to obtain a ZIF-8 layer on the surface of the nanopore aluminum oxide, then carrying out carboxyl or amino modification to obtain a functionalized ZIF-8 layer, and then fixing a specific antibody on the surface of the functionalized ZIF-8 layer by using a cross-linking agent to obtain the optical biosensor. According to the sensor, an AAO nanopore array serves as a structural substrate, a high-activity MOF functional layer is integrated, ultra-sensitive detection is achieved through the precise pore channel confinement effect and the molecular recognition technology, and the prepared optical biosensor has the advantages of being low in cost, high in stability, short in detection time, high in detection sensitivity and specificity and the like.

The utility model provides a kind of refractive index sensing device based on titanium dioxide nanopore array, it is related to micro-nano photoelectronic technical field, the device includes titanium dioxide substrate, the titanium dioxide substrate surface is equipped with the nanopore array of square periodic arrangement;Gold film layer, the gold film layer covers in nanopore side wall and hole bottom surface;Silver film layer, the silver film layer covers in the upper surface of the titanium dioxide substrate, and the silver film layer with the gold film layer is connected at the orifice edge of nanopore;Silica protective layer, the silica protective layer covers in the exposed surface of the gold film layer, silver film layer, forms the package protection of metal layer.The utility model improves sensitivity and quality factor, and with low-cost material and local coating reduces cost and simplifies structure, also rely on protective layer to enhance stability, realize high performance and economy compatibility.

The invention discloses a nanopore array detection flux and precision optimization method and system based on COMSOL, and the method comprises the steps: determining simulation parameters of a nanopore array based on the geometrical shape and size of a to-be-detected molecule; the method comprises the following steps of: utilizing an electrostatic field and a dilute substance transmission physical field in COMSOL Multiphysics, coupling a Poisson equation and a Nernst-Planck equation, and combining simulation parameters, an ion diffusion coefficient of an electrolyte solution, electric field intensity and chemical concentration to finish three-dimensional simulation modeling of a nanopore array; in the nanopore array model, the influence of different arrangement structures on nanopore array current is analyzed by adjusting the center distance, the arrangement mode and the number of adjacent nanopores, and simulation results of nanopore array current characteristics under different designs are obtained; and calculating through hole currents of different nanopore array structures based on simulation results, and carrying out optimization design to finish optimization.

The application belongs to the technical field of molecular detection, and discloses a medicinal material identification system and method; the method comprises the following steps: emitting a topological protection acoustic wave to concentrate DNA of medicinal materials, marking the DNA with a CdTe quantum dot-nucleic acid probe, scraping the sample to extract DNA and performing PCR amplification, designing a logic gate staple chain to prepare a light-controlled origami probe, and injecting a PZT chip nano-pore array to be light-activated, and then, through AFM analysis of free energy, the medicinal materials are identified; the application constructs a complete technical chain from molecular recognition to reliable storage, and comprehensively solves multiple technical bottlenecks of traditional methods in medicinal material identification.

A fiber optic biosensor and detection system includes a transmission fiber and a metal sensing membrane with a nanopore array. The metal sensing membrane is configured to receive incident light from the transmission fiber and reflect the light back into the transmission fiber for detection. This fiber optic biosensor offers advantages such as compactness and portability.

A method of analyzing molecules using a nanopore array including a plurality of cells included on a chip is disclosed. Nanopores are caused to be formed in at least a portion of the plurality of the cells. A first physical measurement of the nanopores is evaluated. It is determined whether to cause the molecules to interact with the nanopores. At least a portion of the nanopores is caused to interact with the molecules. A second physical measurement of the nanopores that indicates a property of the molecules is evaluated. It is determined whether to cause the nanopores to be reformed so that the cells may be reused to interact with additional molecules.

The present invention discloses a method for preparing a nanodiamond array and ultrasensitive detection of miRNA. The nanodiamond array preparation comprises: self-assembling a densely packed monolayer polystyrene (PS) microsphere template on a gold-coated silicon wafer, then thinning the PS microspheres using a reactive ion etching process to obtain a non-densely packed PS microsphere template, then thermally evaporating an aluminum film and ultrasonically removing the PS microspheres to obtain a micropore array; then modifying the surface of the nanodiamond containing NV color centers with a single-stranded DNA probe, and the DNA probe-modified diamond self-assembles into the nanopore array through gold-sulfur bonds. MiRNA detection comprises: first preparing a probe magnetic sphere coupled to the target miRNA and dropping it onto the nanodiamond array, then scanning the target miRNA-coupled magnetic sphere on the surface of the nanodiamond array using a scanning system, a microwave module, and an optical path system, and collecting a light detection magnetic resonance spectrum. The present invention is expected to be applied to the field of early cancer diagnosis.

This invention relates to an antireflection structure, fabrication method, and application of inverted conical nanopores on the surface of SiC thin films, belonging to the field of surface engineering technology for photoelectric detectors. Addressing the problems of short optical path length and high interface reflection loss in existing SiC thin-film ultraviolet photodetectors based on heterogeneous substrates due to limited film thickness, a periodic array of inverted conical nanopores is constructed on the SiC thin film surface. The etching depth is controlled within the film thickness and does not penetrate the entire film, preserving a continuous electrical transmission channel. This structure creates a continuously gradient equivalent refractive index layer on the surface, reducing the surface reflectivity in the 200–400 nm wavelength range. The inverted conical morphology causes large-angle scattering of incident light, increasing the optical path length of ultraviolet light within the confined film and improving absorption. The array is fabricated using patterned masking technology combined with dry etching, suitable for SiC thin-film MSM or PIN detectors, with an average reflectivity of 7.58%, significantly improving the photoelectric conversion efficiency of the device.

The invention discloses a bionic anti-interference-precursor prediction collaborative high-speed vehicle anomaly detection system. The system comprises a composite circuit board, a multi-modal data processing module, a precursor prediction and diagnosis module, a closed-loop feedback optimization module and an emergency collaborative module. The composite circuit board is of a three-layer stacked structure. A bionic lotus root gradient honeycomb and a micro-channel cooling device are arranged on the bottom layer, and temperature self-adaptive control is achieved. The middle layer is integrated with a precursor characteristic acquisition link and an EMI filtering unit, so that high-precision data acquisition is guaranteed; the bionic cicada wing nanopore array and the spectrum analysis unit are arranged on the surface layer, and environmental protection and electromagnetic interference suppression are both considered. The multi-modal data processing module generates vehicle and hardware feature vectors; the precursor prediction module adopts an improved LSTM and outputs graded early warning and abnormal types; the closed-loop feedback module performs bidirectional optimization on hardware parameters and model parameters; and the emergency cooperation module broadcasts abnormal information through the Internet of Vehicles and triggers hierarchical response. According to the invention, the high-speed scene anomaly detection precision and early warning timeliness are improved, and the system stability is enhanced.

The invention discloses a multi-channel virus detection SERS chip based on a resonant cavity and a preparation method thereof, wherein the chip comprises a plurality of detection holes, each of which is composed of a plurality of V-shaped Au nanopore arrays, wherein Au nanoparticles are distributed in the Au nanopore arrays to form an enhanced structure of the Au nanopore resonant cavity; the method firstly plates an Al film on a substrate, then corrodes and oxidizes the Al film, then deposits an Au film on the corroded and oxidized Al film, and finally drips Au nanoparticles on the V-shaped Au nanopore array to obtain a SERS chip. The chip disclosed in the invention specifically captures virus particles through a size effect, and based on the resonant cavity enhancement effect, effectively excites the overall Raman signal of the virus, greatly improves the reproducibility of the Raman signal, and realizes the distinction between different viruses; the preparation method disclosed in the invention is simple to operate, highly repeatable, and can realize uniform preparation of a large area of ​​the chip.

The invention relates to a graphene-based three-waveband absorption enhancement structure and a preparation method thereof. The graphene-based three-waveband absorption enhancement structure comprises a nanopore array, single-layer graphene, a silicon dioxide layer, a back reflection layer and a silicon substrate which are stacked from top to bottom, the absorption peak position and the absorption peak intensity of the three-waveband absorption enhancement structure are dynamically regulated and controlled by adjusting the material and the thickness H2 of the back reflection layer, the thickness T of the silicon dioxide layer, the thickness H1 of the nanopore array, the radius R of the nanopore and the period P of the nanopore array and filling a medium in the nanopore or applying external voltage. The position and the strength of the absorption peak of the absorption enhancement structure can be dynamically regulated and controlled by adjusting structural materials and geometric parameters, critical coupling is achieved, and total absorption of light is achieved; the nanopore array is prepared by adopting a PDMS template imprinting method, so that the method has the advantages of low cost and batch preparation, and also has high resolution.

This invention discloses a metamaterial-based composite stealth film, its preparation method, and its applications, belonging to the field of multi-camouflage technology. The metamaterial-based composite stealth film disclosed in this invention includes an anodic aluminum oxide template and an amorphous alloy film deposited on its surface. The anodic aluminum oxide template has a nanopore array structure. In this invention, the anodic aluminum oxide template and the amorphous alloy film in the metamaterial-based composite stealth film exhibit a synergistic effect, modulating infrared radiation through the photonic bandgap effect, suppressing laser reflection through surface plasmon resonance, and generating visible light camouflage through structural color, thereby achieving multi-camouflage capabilities in visible light, laser, and infrared light.

A method of generating a polymer sequence using a nanopore sequencing device, the nanopore array device comprising nanopore channels (35) formed in a membrane (32) separating two ionic solutions (33, 36), the nanopore channels connecting the ionic solutions, the method comprising: translocating a series of polymers through the nanopore channels; generating a measurement signal during translocation of each polymer through the nanopore channel; analyzing a set of measurement signals acquired from each polymer during translocation of the polymer through the nanopore channel to determine a scale factor for each polymer, applying the scale factor to the measurement signals generated during translocation of the polymer through the nanopore channel to determine a normalized measurement signal value, and generating a polymer sequence for each polymer in the series from the corresponding normalized measurement signal value for each polymer.