85 results about "Nanohole array" patented technology

The invention discloses a molecularly imprinted gold nanopore array substrate for single exosome capture-in-situ Raman detection as well as a preparation method and application of the molecularly imprinted gold nanopore array substrate, and belongs to the technical field of biological detection. The molecularly imprinted gold nanopore array substrate structurally comprises a base material and a nanogold layer from bottom to top, the nanogold layer comprises sunken gold nanopores which are distributed in an array mode, the bottoms of the gold nanopores are provided with modified gold nanoparticles, the gold nanopores comprise imprinted cavities matched with exosomes, the size of each gold nanopore is matched with the size of a single exosome, and the size of each imprinted cavity is matched with the size of the corresponding exosome. The gold nanopore channels distributed in the array form a gap between single exosomes, and the gap is greater than or equal to 1 mu m. According to the invention, a gold nanopore channel can be accurately regulated and controlled, and an exosome molecular imprinting structure is modified in the pore channel, so that capture and detection of a single exosome in body fluid are realized; a good adsorption effect on urine exosomes is achieved, and the adsorbed exosomes can be efficiently captured through the nano pore channels; and the nanopore enhancement factor is as high as 7.27 * 10 < 5 >.

The application relates to a local polarization enhanced nonlinear ionization nanolithography system and method, and belongs to the technical field of femtosecond laser processing. The nanolithography method has the capability of large-area processing, can process a large-area nanohole array on a material through a 'flying dotting' mode, can control the distance between adjacent points in the nanohole array by controlling the speed of a high-precision displacement table and the repetition frequency of femtosecond laser pulses, can control the size of the nanohole by controlling the pulse energy, can control the characteristic line width of a nanowire by controlling the pulse energy and the speed of the high-precision displacement table, and can realize the patterning processing of the nanowire by designing a pattern and introducing the high-precision displacement table.

The invention relates to the technical field of biosensors, and particularly discloses a preparation method of a multi-channel solid nanopore array. The method comprises the following steps: respectively constructing a group of parallel and independent micro-channels on the front and back surfaces of a chip prepared with a suspended dielectric film window array, enabling the micro-channels on the two surfaces to be orthogonally arranged in space, integrating an independent electrode in each micro-channel, and injecting electrolyte; the electrodes of the micro-channel on one side and the electrodes of the micro-channel on the other side are selectively connected through an external control circuit, namely controllable electric fields can be established on the two sides of the thin film window at the unique intersection point corresponding to the electrodes, so that addressing and selective dielectric breakdown of the window are achieved, all the windows on the whole chip are automatically and sequentially addressed, traversed and processed, and the yield of the chip is improved. And forming a nanopore array. By means of the method, a large number of nanopore arrays can be controllably manufactured on a single chip at a time, and nanopore array machining with high throughput, low cost and high consistency is achieved.

A molecular sensing device and molecular sensing method that are based on quantum plexcitonic states on strongly coupled nanophotonic systems are disclosed. The molecular sensing device includes a metasurface, a layer of a semiconducting and / or dielectric material disposed onto a layer of electrically conducting material, a metal nanohole array disposed onto the metasurface, a biological recognition element disposed onto a surface of the metal nanohole array, and where the surface of the metal nanohole array is configured to receive a bioanalyte and a plurality of quantum emitters. The molecular sensing device can be a mixture of quantum emitters, comprising gold, having more than one aspect ratio. The molecular sensing device may include a spectroscopic instrument, including a portable detector. The one or more biological recognition elements are configured to recognize a communicable disease in response to the presence of a specific biological recognition element.

The invention relates to the technical field of surface plasma photonics and micro-nano optical sensing, in particular to a porous super-structure plasma sensor and a preparation method and application thereof.The porous super-structure plasma sensor comprises a substrate, and a first metal layer, a first silicon dioxide layer, a second metal layer and a second silicon dioxide layer are sequentially arranged on the substrate; a plurality of nanopore arrays are arranged on the porous superstructure plasma sensor; and the nanopore array penetrates through the first silicon dioxide layer, the second metal layer and the second silicon dioxide layer. Through the synergistic effect of a metal-medium-metal-medium (such as gold / silicon dioxide / gold / silicon dioxide) multi-layer structure and the periodic nanopore array, strong surface plasmon resonance is excited in a visible light-near infrared band, perfect combination of high absorptivity, high sensitivity and high FOM value is realized, and the sensor can be used for gas concentration change detection, and can be applied to detection of gas concentration changes. The problem that an existing plasmon sensor cannot meet the working requirement of the visible light-near infrared band is solved.

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.

The application discloses a pretreatment cleaning agent processing control system and method, relates to the technical field of processing control, and injects a light-controlled origami probe solution into a nano-pore array of a piezoelectric ceramic chip, uses an AFM probe to apply an axial force to activate an origami structure, records a curve of force change with AFM probe displacement in real time, extracts folding displacement of a folding state area and complete unfolding displacement of a complete unfolding area, integrates and calculates the curve to obtain processing free energy, compares the processing free energy with a free energy range of high-quality cleaning agent finished products in a preset database, and if the processing free energy falls within the range, it is determined that current process parameters are in a reasonable interval, the parameters are maintained, and an efficiency label is marked as 1, and if the processing free energy exceeds the range, it is determined that the process is abnormal, an efficiency label is marked as 0, and dynamic adjustment is triggered. The control method not only improves the precision and efficiency of cleaning agent processing, but also reduces the rate of defective products and production loss, and provides key technical support for large-scale and stable production of high-quality cleaning agents.

The invention discloses a preparation method and application of a silicon nanopore array, and relates to the field of nanopore array manufacturing. The method comprises the following steps: taking an AAO film as a nano template, and transferring the AAO film to the surface of a silicon substrate; depositing a silver nanoparticle array on the AAO thin film to form large-area ordered silver nanoparticle arrangement; and removing the AAO thin film to obtain a silver nanoparticle array on the silicon substrate, immersing the silicon substrate containing silver nanoparticles into an etching solution for reaction, and forming the silicon nanopore array by taking the silver nanoparticles as a metal catalyst. Compared with the prior art, the method has the advantages that the geometrical shape of the nanopore can be accurately controlled, and the method has the characteristics of low cost, high adaptability and repeatability and is suitable for large-scale production to meet diversified requirements in different fields.

The invention relates to a funnel diode realized based on a nanopore modified dielectric polymer molecule monolayer, and relates to the technical field of semiconductor devices. The preparation method of the funnel diode comprises the following steps: forming a three-layer PVP dielectric film through bi-crosslinking treatment, and constructing a nanopore array on the surface of the three-layer PVP dielectric film by using a soft nanoimprint technology to form a polymer nano dielectric layer; sequentially depositing an organic semiconductor layer and a top electrode to complete a diode main body structure; and finally, integrating a molecular memory monolayer formed by gold nanoclusters or copper stearate. The device is compact in structure, the unidirectional convergence of current carriers is realized by utilizing a funnel effect generated by the nanopores, and the device has the characteristics of high-voltage rectification ratio and ultralow working voltage under the coordination of a single molecular layer, and has nonvolatile storage and synaptic plasticity.

The invention discloses a reversible dynamic aperture solid nanopore array based on a temperature-sensitive phase change layer and a preparation method and application of the reversible dynamic aperture solid nanopore array, and belongs to the technical field of single molecule detection and nanostructure regulation, the array introduces the temperature-sensitive phase change layer into the inner wall of a solid nanopore, and when the local temperature crosses the phase transition point of the temperature-sensitive phase change layer, reversible volume change is generated; therefore, the effective aperture of the nanopore is continuously adjustable in a sub-nanometer scale range. An independent micro heating unit and an independent temperature sensing unit are integrated below each nanopore in the array, and single-pore-level accurate temperature control adjustment is achieved in a row-column addressing mode. In combination with ionic current monitoring and an external control module, the aperture can be set in real time according to the size requirements of different target molecules, and dynamic aperture regulation and control with a programmable structure, quick response and good repeatability are realized. The array structure provided by the invention is suitable for single molecule level detection of objects such as multiple types of small molecule pollutants, tumor-related biomarkers, biomacromolecules and the like, and has the advantages of high sensitivity, high flux and wide applicability.

The invention discloses a high-sensitivity optical biochip based on an AAO and ZIF-8 composite structure and a preparation and detection method thereof, and relates to the technical field of optical biochip detection. The preparation method comprises the following steps: coating the surface of nanopore aluminum oxide with ZIF-8 to obtain a ZIF-8 layer on the surface of the nanopore aluminum oxide, then carrying out carboxyl or amino modification to obtain a functionalized ZIF-8 layer, and then fixing a specific antibody on the surface of the functionalized ZIF-8 layer by using a cross-linking agent to obtain the optical biosensor. According to the sensor, an AAO nanopore array serves as a structural substrate, a high-activity MOF functional layer is integrated, ultra-sensitive detection is achieved through the precise pore channel confinement effect and the molecular recognition technology, and the prepared optical biosensor has the advantages of being low in cost, high in stability, short in detection time, high in detection sensitivity and specificity and the like.

The utility model provides a kind of refractive index sensing device based on titanium dioxide nanopore array, it is related to micro-nano photoelectronic technical field, the device includes titanium dioxide substrate, the titanium dioxide substrate surface is equipped with the nanopore array of square periodic arrangement;Gold film layer, the gold film layer covers in nanopore side wall and hole bottom surface;Silver film layer, the silver film layer covers in the upper surface of the titanium dioxide substrate, and the silver film layer with the gold film layer is connected at the orifice edge of nanopore;Silica protective layer, the silica protective layer covers in the exposed surface of the gold film layer, silver film layer, forms the package protection of metal layer.The utility model improves sensitivity and quality factor, and with low-cost material and local coating reduces cost and simplifies structure, also rely on protective layer to enhance stability, realize high performance and economy compatibility.

The invention discloses a nanopore array detection flux and precision optimization method and system based on COMSOL, and the method comprises the steps: determining simulation parameters of a nanopore array based on the geometrical shape and size of a to-be-detected molecule; the method comprises the following steps of: utilizing an electrostatic field and a dilute substance transmission physical field in COMSOL Multiphysics, coupling a Poisson equation and a Nernst-Planck equation, and combining simulation parameters, an ion diffusion coefficient of an electrolyte solution, electric field intensity and chemical concentration to finish three-dimensional simulation modeling of a nanopore array; in the nanopore array model, the influence of different arrangement structures on nanopore array current is analyzed by adjusting the center distance, the arrangement mode and the number of adjacent nanopores, and simulation results of nanopore array current characteristics under different designs are obtained; and calculating through hole currents of different nanopore array structures based on simulation results, and carrying out optimization design to finish optimization.

The application belongs to the technical field of molecular detection, and discloses a medicinal material identification system and method; the method comprises the following steps: emitting a topological protection acoustic wave to concentrate DNA of medicinal materials, marking the DNA with a CdTe quantum dot-nucleic acid probe, scraping the sample to extract DNA and performing PCR amplification, designing a logic gate staple chain to prepare a light-controlled origami probe, and injecting a PZT chip nano-pore array to be light-activated, and then, through AFM analysis of free energy, the medicinal materials are identified; the application constructs a complete technical chain from molecular recognition to reliable storage, and comprehensively solves multiple technical bottlenecks of traditional methods in medicinal material identification.

A fiber optic biosensor and detection system includes a transmission fiber and a metal sensing membrane with a nanopore array. The metal sensing membrane is configured to receive incident light from the transmission fiber and reflect the light back into the transmission fiber for detection. This fiber optic biosensor offers advantages such as compactness and portability.

A method of analyzing molecules using a nanopore array including a plurality of cells included on a chip is disclosed. Nanopores are caused to be formed in at least a portion of the plurality of the cells. A first physical measurement of the nanopores is evaluated. It is determined whether to cause the molecules to interact with the nanopores. At least a portion of the nanopores is caused to interact with the molecules. A second physical measurement of the nanopores that indicates a property of the molecules is evaluated. It is determined whether to cause the nanopores to be reformed so that the cells may be reused to interact with additional molecules.

The present invention discloses a method for preparing a nanodiamond array and ultrasensitive detection of miRNA. The nanodiamond array preparation comprises: self-assembling a densely packed monolayer polystyrene (PS) microsphere template on a gold-coated silicon wafer, then thinning the PS microspheres using a reactive ion etching process to obtain a non-densely packed PS microsphere template, then thermally evaporating an aluminum film and ultrasonically removing the PS microspheres to obtain a micropore array; then modifying the surface of the nanodiamond containing NV color centers with a single-stranded DNA probe, and the DNA probe-modified diamond self-assembles into the nanopore array through gold-sulfur bonds. MiRNA detection comprises: first preparing a probe magnetic sphere coupled to the target miRNA and dropping it onto the nanodiamond array, then scanning the target miRNA-coupled magnetic sphere on the surface of the nanodiamond array using a scanning system, a microwave module, and an optical path system, and collecting a light detection magnetic resonance spectrum. The present invention is expected to be applied to the field of early cancer diagnosis.

This invention relates to an antireflection structure, fabrication method, and application of inverted conical nanopores on the surface of SiC thin films, belonging to the field of surface engineering technology for photoelectric detectors. Addressing the problems of short optical path length and high interface reflection loss in existing SiC thin-film ultraviolet photodetectors based on heterogeneous substrates due to limited film thickness, a periodic array of inverted conical nanopores is constructed on the SiC thin film surface. The etching depth is controlled within the film thickness and does not penetrate the entire film, preserving a continuous electrical transmission channel. This structure creates a continuously gradient equivalent refractive index layer on the surface, reducing the surface reflectivity in the 200–400 nm wavelength range. The inverted conical morphology causes large-angle scattering of incident light, increasing the optical path length of ultraviolet light within the confined film and improving absorption. The array is fabricated using patterned masking technology combined with dry etching, suitable for SiC thin-film MSM or PIN detectors, with an average reflectivity of 7.58%, significantly improving the photoelectric conversion efficiency of the device.

The invention discloses a bionic anti-interference-precursor prediction collaborative high-speed vehicle anomaly detection system. The system comprises a composite circuit board, a multi-modal data processing module, a precursor prediction and diagnosis module, a closed-loop feedback optimization module and an emergency collaborative module. The composite circuit board is of a three-layer stacked structure. A bionic lotus root gradient honeycomb and a micro-channel cooling device are arranged on the bottom layer, and temperature self-adaptive control is achieved. The middle layer is integrated with a precursor characteristic acquisition link and an EMI filtering unit, so that high-precision data acquisition is guaranteed; the bionic cicada wing nanopore array and the spectrum analysis unit are arranged on the surface layer, and environmental protection and electromagnetic interference suppression are both considered. The multi-modal data processing module generates vehicle and hardware feature vectors; the precursor prediction module adopts an improved LSTM and outputs graded early warning and abnormal types; the closed-loop feedback module performs bidirectional optimization on hardware parameters and model parameters; and the emergency cooperation module broadcasts abnormal information through the Internet of Vehicles and triggers hierarchical response. According to the invention, the high-speed scene anomaly detection precision and early warning timeliness are improved, and the system stability is enhanced.

The invention relates to a graphene-based three-waveband absorption enhancement structure and a preparation method thereof. The graphene-based three-waveband absorption enhancement structure comprises a nanopore array, single-layer graphene, a silicon dioxide layer, a back reflection layer and a silicon substrate which are stacked from top to bottom, the absorption peak position and the absorption peak intensity of the three-waveband absorption enhancement structure are dynamically regulated and controlled by adjusting the material and the thickness H2 of the back reflection layer, the thickness T of the silicon dioxide layer, the thickness H1 of the nanopore array, the radius R of the nanopore and the period P of the nanopore array and filling a medium in the nanopore or applying external voltage. The position and the strength of the absorption peak of the absorption enhancement structure can be dynamically regulated and controlled by adjusting structural materials and geometric parameters, critical coupling is achieved, and total absorption of light is achieved; the nanopore array is prepared by adopting a PDMS template imprinting method, so that the method has the advantages of low cost and batch preparation, and also has high resolution.

This invention discloses a metamaterial-based composite stealth film, its preparation method, and its applications, belonging to the field of multi-camouflage technology. The metamaterial-based composite stealth film disclosed in this invention includes an anodic aluminum oxide template and an amorphous alloy film deposited on its surface. The anodic aluminum oxide template has a nanopore array structure. In this invention, the anodic aluminum oxide template and the amorphous alloy film in the metamaterial-based composite stealth film exhibit a synergistic effect, modulating infrared radiation through the photonic bandgap effect, suppressing laser reflection through surface plasmon resonance, and generating visible light camouflage through structural color, thereby achieving multi-camouflage capabilities in visible light, laser, and infrared light.

A method of generating a polymer sequence using a nanopore sequencing device, the nanopore array device comprising nanopore channels (35) formed in a membrane (32) separating two ionic solutions (33, 36), the nanopore channels connecting the ionic solutions, the method comprising: translocating a series of polymers through the nanopore channels; generating a measurement signal during translocation of each polymer through the nanopore channel; analyzing a set of measurement signals acquired from each polymer during translocation of the polymer through the nanopore channel to determine a scale factor for each polymer, applying the scale factor to the measurement signals generated during translocation of the polymer through the nanopore channel to determine a normalized measurement signal value, and generating a polymer sequence for each polymer in the series from the corresponding normalized measurement signal value for each polymer.

The invention provides a design method and a verification method of a middle-infrared band narrow-band metal nanopore array optical filter, and belongs to the technical field of micro-nano optics in order to solve the problems that in the prior art, a device is not ideal in light weight and miniaturization, high in loss, low in resolution ratio, low in energy efficiency and the like. The function of the band-pass multispectral optical filter is shown as a band-pass multispectral optical filter. According to the design method, a method of filling metal NHAs with an amorphous GST material (a-Ge2Sb2Te5) is adopted to carry out special modulation on incident light, and LSPR in the nanopore array is enhanced, so that the local electric field intensity and the energy transmittance of an EOT phenomenon are further improved. According to the design method of the optical filter, the band-pass position can be controlled by geometric parameters of NHAs, and the optical filter has the advantages of high energy efficiency, high spectral resolution, easiness in integration, simple structure and the like, and has important prospects in the fields of mid-infrared high-performance spectral filtering, sensing and detection.

A component (8) adapted to engage with a receiver (6) has an array of contact pads (16) to removeably connect with a corresponding array of connectors (18) on the receiver (6). Each contact pad (16) of the array is electrically connected to the electrode (26) of a corresponding recess or well (28) that is part of a sensor, wherein a membrane is formable across each recess. A conductive grid (102) is configured between the contact pads (16) of the array, to inhibit an electrostatic discharge (ESD) conducting across the recesses or wells and / or direct an ESD away from the recesses or wells.

The present invention discloses a novel metamaterial multispectral imaging chip and a preparation method thereof, belonging to the technical field of optical sensors, comprising: a multi-channel metamaterial filter array, a microlens array and an image sensor, wherein the multi-channel metamaterial filter array is located between the microlens array and the image sensor and integrated with the image sensor; the multi-channel metamaterial filter array includes a base layer, a nanopore array structure layer and a plasma resonance effect covering layer, the plasma resonance effect covering layer is located on the upper surface of the nanopore array structure layer, and the base layer is located on the lower surface of the nanopore array structure layer. The present invention directly constructs and packages the multi-channel metamaterial filter array and the microlens array on a commercial CMOS image sensor silicon chip, realizes imaging and spectral acquisition of multiple wavelength channels, and the constructed multispectral imaging chip is compact.

The application relates to an inorganic nanoparticle array with super-narrow surface lattice resonance and a large-area preparation method thereof, which comprises the following steps: a centimeter-level silicon nanopillar stamp is used to mold a polydimethylsiloxane nanopore array template; the nanopore array template is dipped into a polymer organic solution, and then the nanopore array template is placed on a surface-hydroxylated silicon wafer to form close contact; after the solvent is completely volatilized, a polymer nanopillar array is obtained; metal precursors are adsorbed on the polymer surface through electrostatic action, and the metal ions are reduced by oxygen plasma and the polymer is etched, finally, through thermal annealing, the inorganic nanoparticle array with super-narrow surface lattice resonance is obtained. Compared with the prior art, the application provides a low-cost and high-efficiency universal platform for the preparation of the inorganic nanoparticle array, and makes the large-scale preparation of the next generation of nanophotonic and electronic devices possible.

A plasmon metasurface sensor based on an aluminum-titanium nitride alternating multi-nanometer lamination relates to the technical field of plasmon metasurfaces and comprises a substrate layer, a plurality of layers of aluminum films and a plurality of layers of titanium nitride films. The aluminum films and the titanium nitride films are alternately arranged from bottom to top and are sequentially compounded on the substrate layer; a periodic nanopore array is formed in the substrate layer; and the number of layers of the aluminum films is consistent with that of the titanium nitride films. Through the aluminum-titanium nitride alternate multi-nano laminated structure design, the optical near field and sensing regulation range in biomolecule detection in a plasmon mode is expanded, the interaction range between light and substances is increased, the substance sensing performance is effectively improved, the biological detection accuracy is improved, and the wide multi-marker detection requirement is met; through the aluminum-titanium nitride alternating multi-nano laminated structure design, the strong dependence of a traditional plasmon sensing material on precious metal is eliminated.

The invention discloses a preparation method of a plasmon nanopore array, which comprises the following steps: immersing a substrate sheet in a positively charged silane coupling agent solution, and drying to obtain a first surface; forming a single-layer polymer microsphere colloid on the first surface through self-assembly, and forming to obtain a second surface; removing the silane coupling agent layer, which is not shielded by the microspheres, on the second surface to obtain a third surface; removing the microspheres on the third surface, and exposing the array region covered with the silane coupling agent layer to obtain a fourth surface; the fourth surface is immersed in a gold particle solution containing a protective agent, gold particles are electrostatically adsorbed in the array area, and a fifth surface is obtained; and performing high-temperature annealing on the fifth surface to obtain the plasmon nanopore array. The method provided by the invention is simple in preparation process and controllable in structure, and has wide application prospects in the aspects of life science, medical diagnosis and the like.

Disclosed are a light emitting diode and a manufacturing method thereof, comprising: a substrate; an epitaxial layer on the substrate, the epitaxial layer comprising a first semiconductor layer, a multi-quantum well layer and a second semiconductor layer stacked in sequence from bottom to top, the first semiconductor layer and the second semiconductor layer having opposite doping types; a barrier layer between the first semiconductor layer and the multi-quantum well layer; a guide layer between the first semiconductor layer and the barrier layer; and a nano-pore array perpendicular to the surface of the first semiconductor layer and located in at least the guide layer and the first semiconductor layer. The light emitting diode and the manufacturing method thereof provided by the present application set the barrier layer and the guide layer between the first semiconductor layer and the multi-quantum well layer, form the nano-pore array penetrating through the guide layer and the first semiconductor layer and perpendicular to the surface of the first semiconductor layer, so as to adjust the light emission of the light emitting diode.

The invention discloses a nanopore array induced hydrogen tungsten bronze proton sponge electrode and a preparation method and application thereof. A two-dimensional layered nanosheet with a nanopore array is adopted, and the nanopore array induced hydrogen tungsten bronze proton sponge electrode material catalyst is obtained. The nanopore array induced hydrogen tungsten bronze proton sponge electrode material electrocatalyst can provide insertion, storage and removal of active hydrogen due to a layered structure and multiple oxygen vacancies, reinforces combination with NO to generate ammonia, has a relatively high electrochemical active area, can meet most important parameters required by practical application, and has a wide application prospect. As an electrocatalyst, the catalyst has good catalytic performance when being used for flue gas nitrogen oxide electroreduction, high Faraday efficiency can be achieved, and nitrogen oxide can be stably catalyzed to generate ammonia.