19 results about "Fluid cell" patented technology

The invention discloses a microfluidic reaction chip, a sample pretreatment device and a control method thereof. The microfluidic reaction chip comprises a chip body, a purification assembly and a liquid storage unit for preloading reaction liquid, wherein the chip body is provided with a containing groove, a sample liquid pool, a uniform mixing pool and a liquid collecting pool; the purification assembly can be assembled on the chip body and is communicated with the accommodating groove, the sample liquid pool, the uniform mixing pool and the collection liquid pool; the liquid storage unit can be assembled in the containing groove and release reaction liquid, the sample liquid pool is used for containing a sample and located on a flowing path of the reaction liquid, and the sample and the reaction liquid can controllably flow between the sample liquid pool and the uniform mixing pool in a reciprocating mode to obtain mixed liquid; the purification assembly is located on a flowing path of the mixed liquid in the sample liquid pool, and a purified solution obtained through separation of the purification assembly flows into the collection liquid pool. The microfluidic reaction chip disclosed by the invention can be used for obtaining a purified solution for flow type sample loading analysis through reaction. The pre-sample treatment device is small in size, and the pre-sample treatment cost is reduced.

Systems and methods determine physical properties of drilling mud by modeling velocity and dispersion behavior of drilling mud based on signals received from a downhole fluid cell device. The systems and methods may determine fluid and / or gas properties. The systems and methods may provide enhancement to interpretation of data from logging tools. The systems and methods may be integrated with a drilling control system to design optimum drilling mud and / or provide real-time monitoring and adjustment of drilling mud properties.

The application provides a kind of marine structure flow field simulation method, the method comprises: generating calculation grid and object surface grid for flow field simulation;Initialize object surface grid level set function field;According to flow field information, calculate the force condition of object surface, calculate object translation vector and rotation vector;Complete data mapping of object surface grid to calculation grid, obtain the level set function field of calculation grid;According to the obtained calculation grid level set function field, divide cell type;Carry out geometric calculation to cut cell, based on cut cell flow field reconstruction strategy, complete fluid cell, cut cell estimated speed update;Solve pressure Poisson equation, obtain pressure field, pressure gradient, update velocity field according to the obtained pressure gradient, obtain the final velocity field satisfying continuity condition.The marine structure flow field simulation method of the application greatly improves the numerical simulation efficiency of complex structure flow field, and reduces the implementation difficulty.

The invention discloses a parallel type liquid pool, which comprises a 4k shielding layer and a 1K shielding layer arranged in the 4k shielding layer, a secondary liquid pool, a parallel flow resistance unit, a sample table and a heater are arranged in the 1K shielding layer; the secondary liquid pool is connected with a cold source through an input pipeline, and the input pipeline is connected with a parallel flow resistance unit; a first-stage liquid pool and a first-stage flow resistance unit are arranged outside the 1K shielding layer, the first-stage liquid pool is connected with a cold source through an input pipeline, and the first-stage flow resistance unit is connected to the input pipeline; and gas outlets of the second-stage liquid pool and the first-stage liquid pool are connected with a pump through an output pipeline. According to the invention, fluid shunting and flow velocity regulation and control are realized through the parallel flow resistance structure, stable standing of the fluid and high-temperature and low-temperature variable temperature isolation are guaranteed in combination with the parallel liquid pool, the problem that wide-range variable temperature measurement cannot be met in the prior art is solved, and the reliability and precision of fluid treatment and temperature-related experiments are improved.

The utility model provides a continuous microneedle sampling interstitial fluid detection device which comprises a pressing piece, a pressing cavity is arranged in the pressing piece, a liquid storage tank is arranged at the lower end of the pressing cavity and is attached to the upper surface of an electrochemical detection electrode, a microneedle seat is arranged on the lower surface of the electrochemical detection electrode, a microneedle head is embedded in the microneedle seat, and the microneedle head is connected with the pressing cavity. A micro-needle channel penetrates through the interior of the micro-needle head, a negative pressure cavity is defined by the upper surface of the micro-needle base, the inner ring wall of the electrochemical detection electrode and the inner ring wall of the liquid storage tank, the electrochemical detection electrode comprises a detection area and a circuit area, a liquid discharging channel is formed in the liquid storage tank, the negative pressure cavity is connected with the micro-fluidic chip through the liquid discharging channel, and the pressing piece is extruded to press the micro-needle head. When the pressing cavity disappears and the pressing piece is loosened, the pressing piece is in a rebound state, the pressing cavity is in a recovery state, and an integral cavity gap formed by the negative pressure cavity and the microneedle channel is in a negative pressure state, so that the interstitial fluid can be continuously and rapidly sampled and detected.

The application discloses a kind of dosing device and system for cell culture, dosing device includes liquid storage mechanism and gas supply mechanism, liquid storage mechanism includes several liquid storage pools, the bottom of liquid storage pool is equipped with liquid outlet hole, liquid outlet hole is set so that the liquid inside liquid storage pool only flows out under the condition that the air pressure in liquid storage pool exceeds first air pressure;Gas supply mechanism includes several gas pipelines, each gas pipeline is sealedly connected with the upper end opening of liquid storage pool one by one, and gas supply mechanism transports preset air pressure greater than first air pressure into liquid storage pool through gas pipeline.The dosing device of the application can completely discharge the liquid in the liquid storage pool by setting the liquid outlet hole at the bottom of the liquid storage pool, avoiding the waste of drugs, and the structure is simple, easy to operate;On the other hand, the structure of the dosing device of the application is easy to cooperate with the microscopic imaging mechanism, to realize the synchronization of dosing and microscopic imaging, and the reaction of cells to drugs can be monitored.

A spectrum in-situ detection electrolytic tank suitable for insoluble gas is characterized in that an electrolytic tank cover is in a circular truncated cone shape with a wide upper part, a narrow lower part and an open top, and an optical window is arranged at the bottom of the electrolytic tank cover; a horizontal upper silica gel sheet and a horizontal lower silica gel sheet are arranged in the electrolytic tank main tank from top to bottom; a corrosion-resistant metal plate is arranged at the bottom of the lower silica gel sheet; an area above the corrosion-resistant metal plate is defined as a liquid pool; an area below the corrosion-resistant metal plate is a gas pool; the center of the upper silica gel sheet and the center of the lower silica gel sheet are respectively provided with a circular through hole, and a sheet-shaped working electrode is arranged between the through hole of the upper silica gel sheet and the through hole of the lower silica gel sheet. The circular ring sealing ring, the circular through holes in the centers of the upper silica gel sheet and the lower silica gel sheet form a step-shaped ventilation channel, bubbles generated in the electrolysis process and bubbles leaking out of a gap between the working electrode and the lower silica gel sheet are guided to penetrate out of the ventilation grid at the top of the annular sealing ring, and the bubbles are prevented from being accumulated at the bottom of the optical window.

This disclosure relates to the adjustment of the measurement of cellular concentration in a fluid determined by a sensor. [Solution] The biofluid processing apparatus 10 includes a pump system and a valve system, a control unit, and an optical detection assembly. During the execution of the biofluid processing procedure, the control unit controls the operation of the pump system and the valve system to separate the cell-containing fluid from the blood of the blood supply source, and further controls the optical detection assembly to irradiate the cell-containing fluid with light. The control unit receives a signal from the optical detection assembly indicating the intensity of the light transmitted through the cell-containing fluid. The control unit receives or calculates an adjustment coefficient derived from historical data reflecting a cell collection procedure previously performed on the same blood supply source from which the cells were collected. The control unit determines the adjusted cell concentration of the cell-containing fluid based at least in part on the signal from the photodetector and the adjustment coefficient.

The invention relates to the technical field of radiopharmaceutical labeling, and provides a microfluidics-based radiopharmaceutical labeling automation device and method, and the microfluidics-based radiopharmaceutical labeling automation device comprises a plurality of reactant sample injectors; the micro-channel reactor is connected with the plurality of reactant sample injectors; the purification column is connected with the micro-channel reactor; the plurality of leacheate sample injectors are connected with the purification column; the effluent liquid storage tank is connected with the purification column; the leacheate storage tank is connected with the purification column; the two-way valve is arranged on the pipeline between the microchannel reactor and the purification column and is used for switching the flow direction of the flow path; the intermediate product liquid storage tank is connected with one outlet of the two-way valve; the control system is electrically connected with the reactant sample injector, the leacheate sample injector, the two-way valve, the intermediate product driving pump and the micro-channel reactor. Liquid is accurately controlled through the control system, physical isolation of radioactive operation and personnel operation is achieved, efficient diffusion mixing is achieved through the micro-flow control technology, and the reaction rate is increased.

The application relates to the technical field of automatic control, in particular to a solid-liquid reaction control device based on digital microfluidics, which comprises a control module, a detection module, a solid fixing module, a solid plate and a digital microfluidic chip; the solid fixing module can be fixed below the digital microfluidic chip; the solid plate is used for loading solid and is detachable, can be inserted into the solid fixing module and can send the solid into the digital microfluidic chip; the digital microfluidic chip is provided with an in-out sample area, a solid-liquid reaction area and a detection area, and the areas are connected through electrodes; the in-out sample area is provided with a liquid storage pool which is used for storing reaction solution; the control module controls the voltage of each electrode to realize micro-droplet movement; the solution in the liquid storage pool is controlled to move to the solid-liquid reaction area, contacts the solid and reacts, and the solution can also be moved out of the solid-liquid reaction area to interrupt the reaction process of the solid; the control module can also control the to-be-detected micro-droplet to move to the detection area; and the detection module detects the to-be-detected micro-droplet in the detection area through a sensor probe thereof.

This invention relates to the field of photoelectric detection and particle analysis technology, specifically a high-sensitivity, wide dynamic range single-particle optical sensor. It includes a fluid cell, a light source, an extinction detection unit, a scattering detection unit, and a signal synthesis unit. The fluid cell forms a detection channel for particles carried by the fluid to pass through, and the light source emits a detection beam into the detection channel. The extinction detection unit is positioned in the transmission optical path to acquire the extinction signal, and the scattering detection unit is positioned in the scattering optical path to acquire the scattering signal. The signal synthesis unit sums or weighted sums the extinction and scattering signals to generate a single composite signal, and outputs particle size information and / or counting information based on the composite signal. The composite signal is dominated by the scattering signal in the small particle size range, the extinction signal in the large particle size range, and achieves a smooth transition in the transition range.

This invention relates to the field of Worthington jets, specifically to an apparatus and method for quantitative analysis of the mechanical energy of Worthington jets. The apparatus includes an exciter position and energy control component, a release component, a liquid pool, a digital image recording component, and a data analysis system. The release component carries and releases the exciter and is movably connected to the exciter position and energy control component, which drives the release component to the release position. The digital image recording component captures images of the Worthington jet occurring in the liquid pool. The data analysis system is connected to the image recording component and analyzes the image information acquired by the image recording component to obtain the quantitative analysis results of the Worthington jet's mechanical energy. This invention can obtain accurate mechanical energy of the Worthington jet object.

This invention belongs to the field of urine electrolyte content detection technology, specifically relating to a miniature integrated device and method for measuring urine electrolyte content. The device includes a first electrode on a silicon substrate, an internal reference liquid reservoir and a third microfluidic channel on a third chamber layer, a sample reservoir and a second microfluidic channel in a second chamber layer, a second electrode and a connecting cell on a silicon-based electrode layer, a first microfluidic channel in the first chamber layer, a potential measuring instrument on a cover plate, and a first, second, third, fourth, and fifth injection port on the entire device. Based on silicon micro-etching technology and combined with the principle of ion-selective electrode detection, this invention, through miniaturization of electrodes and electrolyte chambers, provides a low-cost, portable biological electrolyte detection instrument. Furthermore, by increasing the number of internal reference liquid containers, the number of ion types that the product can detect can be further increased.

The utility model belongs to the technical field of cutting fluid concentration detection, and discloses machining cutting fluid concentration detection equipment which comprises a liquid storage tank, a guide pipe fixedly sleeves one end of the liquid storage tank, a sampling bottle fixedly sleeves one end, opposite to the liquid storage tank, of the guide pipe, and an inner barrel movably sleeves a lining at the bottom end of the sampling bottle. A circular cone top is arranged at the top of the inner barrel, and a sealing sleeve is fixedly mounted on the outer side wall of the inner barrel in a sleeving manner; according to the device, the liquid storage tank and the sampling bottle are arranged, so that main body bearing of structures on the device is facilitated, and meanwhile, a guide pipe, an inner barrel, a sealing sleeve, a circulating hole, a liquid discharging pipe, a transparent observation window, scale marks, a transparent cylinder, a filtering hole, a fixing rod, a density ball and a high-light flashlight are arranged in a matched manner; the device can detect the concentration of a part of cutting fluid guided out from the liquid storage tank, and can prevent the problems that metal impurities entering the cutting fluid cannot be discharged and are accumulated and blocked at the same time.

The present invention relates to: a paper-based microfluidic device including a plurality of puddles and hydrophobic barriers; and a manufacturing method thereof. Specifically, the paper-based microfluidic device according to the present invention can move a fluid without external power due to the porous structure of a substrate made of paper, and thus can provide a simple and highly portable analysis platform. In addition, unlike conventional μPADs, the paper-based microfluidic device is fully compatible with 96-well plates and the like and thus can be easily integrated with existing laboratory equipment or smartphones, can simultaneously process multiple samples on a single device (chip), can reduce experimental costs by using small amounts of reagents, and is highly durable and stable and thus can be widely used in various biological, clinical, and environmental analysis environments, such as chromaticity, absorbance, and fluorescence analysis environments.

The application discloses a sample analyzer and a control method thereof. The sample analyzer comprises a flow chamber, a sampling module, a sheath liquid module, a driving module and a control module. The sampling module is connected to the flow chamber through a pipeline. The sheath liquid module comprises a sheath liquid pool configured to provide sheath liquid. The control method comprises the following steps: the control module controls the driving module to draw gas through the sampling module to form a first gas bubble; the control module controls the driving module to draw a sample through the sampling module; and the control module controls the driving module to transmit the first gas bubble and the sample to the flow chamber, and controls the sheath liquid module to transmit the sheath liquid in the sheath liquid pool to the flow chamber. Therefore, the sample and the sheath liquid in the pipeline can be separated through the first gas bubble, the particles in the sample can be prevented from diffusing into the sheath liquid, the loss of the particles can be reduced, the concentration of the sample entering the flow chamber can be maintained, and the accuracy of particle detection can be improved.

The invention is applicable to the technical field of interface science and precision measurement, and provides a micro-fluidic chip-based limited gas-liquid interface gas-liquid mixing layer structure characterization method, which comprises the following steps: constructing a micro-fluidic chip containing a micro liquid storage tank and a main micro-channel; injecting liquid into the chip to fully fill the micro liquid storage tank, and injecting gas into the main micro channel to form a stable limited interface which takes a gas phase as a continuous phase and in which static liquid is attached to the wall of the liquid storage tank; scanning along a vertical interface direction by using a Raman spectrometer, and collecting continuous Raman signals from a gas phase and an interface region to a liquid phase; and dividing and calculating the thickness of a gas-liquid molecule coexisting mixed layer by analyzing a change curve of a gas-liquid phase characteristic peak intensity ratio along with a spatial position. According to the invention, in-situ, lossless and high-resolution direct measurement of the micro-scale limited gas-liquid interface in a dynamic environment is realized, a molecular mixing layer structure at the interface can be accurately revealed, and a powerful tool is provided for fundamental research in the fields of gas hydrates, microreactors, geological sequestration and the like.