Slow-release pain-easing antibacterial absorbable dressing and preparation method thereof

A slow-release, antibacterial activity technology, used in absorbent pads, rayon manufacturing, conjugated rayon, etc., can solve the problems of weak strength, poor antibacterial effect, no analgesic effect, etc., to prolong the release time, avoid burst effect

Inactive Publication Date: 2019-05-14
HUAINAN UNITED UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, when the existing medical dressings are used as wet dressings, their strength is weak, their antibacterial effect is not good, and they have no analgesic effect

Method used

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  • Slow-release pain-easing antibacterial absorbable dressing and preparation method thereof
  • Slow-release pain-easing antibacterial absorbable dressing and preparation method thereof
  • Slow-release pain-easing antibacterial absorbable dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of slow-release analgesic antibacterial absorbable dressing, comprising the following steps:

[0032] (a) the preparation of spinning solution A: take chitosan and polylactic acid, add glacial acetic acid of 90wt% as solvent, be mixed with polymer total amount and be the mixed solution A of 5wt%, then described mixed solution A is in Reflux in a water bath at 90°C for 10 hours to fully dissolve it, then add the analgesic active drug bupivacaine into the mixed solution A, and magnetically stir until it dissolves and disperses evenly to obtain the spinning solution A; the chitosan and The mass ratio of the polylactic acid is 1:9; the mass fraction of the analgesic drug bupivacaine in the spinning solution A is 0.2wt%;

[0033] (b) Preparation of spinning solution B: take chitosan and polylactic acid in addition, add 90wt% glacial acetic acid as solvent, be mixed with the mixed solution B that the polymer total amount is 5wt%, then mix the mixed soluti...

Embodiment 2

[0038] A preparation method of slow-release analgesic antibacterial absorbable dressing, comprising the following steps:

[0039] (a) the preparation of spinning solution A: take chitosan and polylactic acid, add glacial acetic acid of 90wt% as solvent, be mixed with polymer total amount and be the mixed solution A of 5wt%, then described mixed solution A is in Reflux in a water bath at 90° C. for 10 hours to fully dissolve it, then add analgesic active drug lidocaine into the mixed solution A, and magnetically stir until it dissolves and disperses evenly to obtain a spinning solution A; the chitosan and the The mass ratio of the polylactic acid is 1:9; the mass fraction of the analgesic drug lidocaine in the spinning solution A is 0.3wt%;

[0040] (b) Preparation of spinning solution B: take chitosan and polylactic acid in addition, add 90wt% glacial acetic acid as solvent, be mixed with the mixed solution B that the polymer total amount is 5wt%, then mix the mixed solution B...

Embodiment 3

[0045] A preparation method of slow-release analgesic antibacterial absorbable dressing, comprising the following steps:

[0046] (a) the preparation of spinning solution A: take chitosan and polylactic acid, add glacial acetic acid of 90wt% as solvent, be mixed with polymer total amount and be the mixed solution A of 5wt%, then described mixed solution A is in Reflux in a water bath at 90°C for 10 hours to fully dissolve it, then add the analgesic active drug prilocaine into the mixed solution A, and magnetically stir until it dissolves and disperses evenly to obtain the spinning solution A; the chitosan and the The mass ratio of the polylactic acid is 1:9; the mass fraction of the analgesic drug prilocaine in the spinning solution A is 0.4wt%;

[0047] (b) Preparation of spinning solution B: take chitosan and polylactic acid in addition, add 90wt% glacial acetic acid as solvent, be mixed with the mixed solution B that the polymer total amount is 5wt%, then mix the mixed solu...

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Abstract

The invention provides a preparation method of a slow-release pain-easing antibacterial absorbable dressing. The preparation method includes the following steps that a, a spinning solution A is prepared; b, a spinning solution B is prepared; c, electrostatic spinning is conducted, wherein the spinning solution A in the step a and the spinning solution B in the second b are added into an electrostatic spinning device comprising two single-channel injection pumps and subjected to electrostatic spinning, so that electrostatic spinning fiber membranes are obtained, wherein the included angle formed by single-axis spray nozzles (2) of the two single-channel injection pumps (1) is 60-180 degrees; d, the electrostatic spinning fiber membranes are crosslinked fixedly. Through the preparation method of the slow-release pain-easing antibacterial absorbable dressing, the speed of diffusing medicine in a carrier is decreased, release time is prolonged, the medicine is released gradually on the wounded part, and the effective medicine concentration of the wounded part can be kept for a long term. The invention further provides the slow-release pain-easing antibacterial absorbable dressing.

Description

technical field [0001] The invention relates to the technical field of medical material preparation, in particular to a sustained-release analgesic antibacterial absorbable dressing and a preparation method thereof. Background technique [0002] The skin and mucous membranes of the human body are the barriers to maintain the stability of the human internal environment and prevent the invasion of microorganisms. Damage to the skin and mucous membranes caused by ulcers, wounds, burns, and various chronic diseases will cause bacterial infection, increased metabolism, and excessive loss of water and protein. A series of problems in the body, such as endocrine and immune system dysfunction, may be life-threatening in serious cases. Early dressings only had the single function of simple protection and infection prevention, and mainly played the role of isolation and antibacterial, but they often caused dry wounds, destroyed healthy growth factors, and were easy to adhere to new ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/20A61L15/26A61L15/44A61L15/46D01F1/10D01F8/14D01F8/18D04H1/4382D04H1/728
Inventor 姜坤王谦郑榕邓楠任晓燕
Owner HUAINAN UNITED UNIVERSITY
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