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Preparation method of 3-methoxy-4-iodoaniline

A technology of methoxyl and iodoaniline, which is applied in the field of compound synthesis, can solve the problems of low yield, large amount of three wastes, and high cost, and achieve the effects of high impurity removal rate, safe reaction temperature, and less three wastes

Inactive Publication Date: 2019-05-21
NINGXIA UNIVERSITY
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Problems solved by technology

[0002] Domestically, there are few types of iodine-containing organic intermediates, and the yield is not ideal. At the same time, affected by raw materials and processes, the preparation method is not green enough, accompanied by the generation of acid liquid and waste gas.
Among them, 3-methoxy-4-iodoaniline is used as an iodine-containing organic intermediate, and its synthesis method is rarely reported, the technical process is incomplete, and it faces problems such as low yield, large amount of three wastes, and high cost.

Method used

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  • Preparation method of 3-methoxy-4-iodoaniline
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  • Preparation method of 3-methoxy-4-iodoaniline

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Embodiment Construction

[0017] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0018] The embodiment of the present invention provides a synthetic method of 3-methoxy-4-iodoaniline, comprising the following steps:

[0019] S1. Synthesis of 1-iodo-2-methoxy-4-nitrobenzene.

[0020] Add 1.7g (0.01mol) of 2-methoxy-4-nitroaniline into a 100ml three-necked flask and dissolve it in 8ml of 20.0% hydrochloric acid, turn on the magnetic stirring, and react for 20-30min, when the reaction system is stirred to off-white Then start the follow-up reaction, cool the reaction solution to below 0°C in the low-temperature reaction bath, after the temperature drops below 0°C, slowly add the prepared 6% sodium nitrite solution dropwise (co...

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Abstract

The invention relates to a preparation method of 3-methoxy-4-iodoaniline. Cheap 2-methoxy-4-nitroaniline easy to obtain is selected as a raw material, a diazotization reaction is performed under the acid condition, activated zinc is used for being subjected to a reduction reaction with hydrochloric acid, and the target product 3-methoxy-4-iodoaniline is obtained. The technology is simple in path,raw materials are cheap and easy to obtain, operation is easy, on the condition that no phase transfer catalyst is added, due to mild reaction conditions, the yields of products obtained by the two-step reactions are both high, and waste gas, water and industrial residues generated in the experiment process are little.

Description

technical field [0001] The invention relates to the field of compound synthesis, in particular to a preparation method of 3-methoxy-4-iodoaniline. Background technique [0002] Domestically, there are few types of iodine-containing organic intermediates, and the yield is not ideal. At the same time, affected by raw materials and processes, the preparation method is not green enough, accompanied by the generation of acid liquid and waste gas. Among them, 3-methoxy-4-iodoaniline is an iodine-containing organic intermediate, and its synthesis method is rarely reported, the technical process is incomplete, and it faces problems such as low yield, large amount of three wastes, and high cost. Contents of the invention [0003] The object of the present invention is to provide a low-cost and green and environment-friendly preparation method to solve the above-mentioned technical problems. The invention has the advantages of simple process path, cheap and easy-to-obtain raw mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C201/12C07C205/37C07C213/02C07C217/84C07C245/20
Inventor 杨金会迟九蓉严志明冯月基王石浩志
Owner NINGXIA UNIVERSITY
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