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Biologic polysaccharide having effects of promoting hair generation, developing hair and preventing hair loss and application of biologic polysaccharide

A kind of anti-hair loss and purpose technology, applied in the field of biotechnology and pharmaceutical preparations, can solve the problems of lack of hair growth drugs and the like

Active Publication Date: 2019-08-06
ZHEJIANG GLLION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of society, people pay more and more attention to the hair that has both protective and aesthetic functions, but there is still a lack of clinically effective hair growth-stimulating drugs

Method used

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  • Biologic polysaccharide having effects of promoting hair generation, developing hair and preventing hair loss and application of biologic polysaccharide
  • Biologic polysaccharide having effects of promoting hair generation, developing hair and preventing hair loss and application of biologic polysaccharide
  • Biologic polysaccharide having effects of promoting hair generation, developing hair and preventing hair loss and application of biologic polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0224] Example 1, the acquisition and determination of β-glucan

[0225] This example only takes the β-glucan obtained by fermentation of Schizophyllum as an example, but is not limited thereto.

[0226] 1. Obtaining the fermentation broth of Schizophyllum strains

[0227] The fermented liquid in the following examples is passed through fermentation Schizophyllum strain (Schizophyllum commune Fr-1003, catalogue: 38548 TM , purchased from the American Type Culture Collection [ATCC]), the details are as follows:

[0228] 1. Activation of Schizophyllum strains: 200g / L of potatoes, 30g / L of glucose, 10g / L of sodium chloride, and 20g / L of agar are made into a plate medium, and the strains of Schizophyllum are inoculated on the plate medium , cultured in a constant temperature incubator at 25°C for 7 days to obtain plate mycelium;

[0229] 2. Seed activation: put potato starch 100g / L, glucose 40g / L, yeast extract 2g / L, yeast extract powder 2g / L, and water into a shaker flask, a...

Embodiment 2

[0281] Example 2 β-glucan promotes hair growth experiment (rat)

[0282] 1. Experimental method

[0283] 1. Take 8 Wistar rats and set aside;

[0284] 2. Take 100g of rosin and paraffin in a small beaker, heat, melt and mix in a boiling water bath, and keep warm at 70°C to prevent solidification for later use;

[0285] 3. Weigh the body weight of each rat, and use chloral for intraperitoneal injection anesthesia according to the dosage of 0.3% of the body weight;

[0286] 4. Select an area on the left and right sides of the back of the anesthetized rat, and evenly apply an appropriate amount of rosin and paraffin wax mixture. After cooling and solidifying, peel it off against the hair growth direction to expose the hairless back skin of the rat;

[0287] 5. Rats were divided into two groups after hair removal on the back, and 1 mg / mL glycerin and 1 mg / mL Schizophyllum β-glucan (prepared according to the method in Example 1) were applied to both sides of the back of each rat ...

Embodiment 3

[0291] Example 3 β-glucan optimizes the basic characteristics of AES

[0292] 1. Experimental method

[0293] 1. Take two tubes of 25mL 10% AES aqueous solution, add 1mg / mL Schizophyllum β-glucan (prepared according to the method in Example 1) to the experimental group, and add 1mg / mL deionized water to the control group. Mix the two tubes separately, shake vigorously for 30 seconds, and immediately observe the amount of foam produced.

[0294] 2. Take two tubes of 25mL 10% AES aqueous solution, add 1mg / mL Schizophyllum β-glucan (prepared according to the method in Example 1) to the experimental group, and add 1mg / mL deionized water to the control group. Mix the two tubes separately, shake vigorously for 30s, and immediately observe the defoaming speed.

[0295] 3. Take two tubes of 25mL 10% AES aqueous solution, add 1mg / mL Schizophyllum β-glucan (prepared according to the method in Example 1) to the experimental group, and add 1mg / mL deionized water to the control group. M...

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Abstract

The invention relates to biologic polysaccharide having effects of promoting hair generation, developing hair and preventing hair loss and an application of the biologic polysaccharide. Particularly,beta-glucan, particularly beta-glucan having natural solubility, high molecular weight and high viscosity (such as schizophyllum commune beta-glucan) can effectively promote hair development and / or prevent hair loss. Experiment indicates that the beta-glucan can obviously promote hair follicle in interruptio to enter the growth period, so that the hair follicle can be in the growth period for a long time, hair can be promoted to be regenerate and grow, the hair loss can be prevented, the hair can be developed, and the biologic polysaccharide has the efficacy of removing and preventing dandruffand relieving itching.

Description

technical field [0001] The invention relates to the fields of biotechnology and pharmaceutical preparations, in particular to biological polysaccharides capable of growing hair, fixing hair and preventing hair loss and application thereof. Background technique [0002] Hair growth is a cyclical process, mainly through three processes: anagen stage, catagen stage, and telogen stage. Hair growth is not only affected by age, gender, and location, but also by body hormone levels, diseases, and external factors. [0003] Hair has the functions of defense, protection and increasing communication and beauty. Hair is produced by the hair follicle, a skin appendage with a complex structure that continues to grow in cycles of growth, catagen, and rest. Once the hair follicle cycle is out of balance, it will affect the normal growth of hair follicles and lead to the occurrence of hair loss diseases. With the development of society, people pay more and more attention to the hair whic...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K31/716A61K45/06A61P17/14A61P17/00A61Q7/00
CPCA61K8/73A61K31/716A61K45/06A61P17/14A61P17/00A61Q7/00A61K2300/00
Inventor 郭宏亮叶榛吴佳迪庄秀园林檬王轩朱勤健
Owner ZHEJIANG GLLION BIOTECH CO LTD
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