Application of serum exosome has_circ_0004771 in preparation of diagnostic reagent for alcohol dependence syndrome

A technology for alcohol dependence and syndrome, applied in the determination/testing of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve problems such as deficiency, and achieve the effect of convenient and easy diagnosis
CN110157792APending Publication Date: 2019-08-23SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
Publication Date
2019-08-23

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Abstract

The invention discloses application of a serum exosome has_circ_0004771 in preparation of a diagnostic reagent for the alcohol dependence syndrome (AD). According to the application, by studying changes of the expression of circ RNA in a serum exosome of a patient with the alcohol dependence syndrome, the circ RNA with the most prominent significance is screened out, and when applied to clinical detection of the AD, the circ RNA achieves the specific effectiveness. The serum exosome has_circ_0004771 achieves the high value of diagnosing the AD, the expression level of the serum exosome has_circ_0004771 is related to the severity degree of the AD, and the serum exosome has_circ_0004771 can be taken as a marker for AD diagnosis and evaluation of the severity degree of the AD. Through the serum circ RNA marker and development and application of diagnostic kits, diagnosis for the AD can be more convenient and easy to implement, the foundation is laid for quickly and accurately mastering the illness state of the patient by a clinician and improving the clinical treatment effect, and assistance is provided for discovery of novel small molecule drug targets with the potential treatment value.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to a serum exosome circular biomarker has_circ_0004771 for the diagnosis and severity assessment of alcohol dependence syndrome, its detection primer, a kit for detecting the marker, and the detection primer , the kit for detecting the marker or the application of the marker in the diagnosis and severity assessment of alcohol dependence syndrome. Background technique

[0002] Alcohol dependence syndrome (AD) is defined as uncontrollable alcohol consumption in patients with negative effects on physical and mental health and interpersonal relationships. AD is very common in both developed and developing countries, with a prevalence of approximately 10% of the global population. Although careful efforts have been made to develop a DSM-IV / v based interview format for AD screening, less than 15% of patients are reported to be diagnosed and treated. Therefore, exploring a new bi...

Claims

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