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Application of serum exosome has_circ_0004771 in preparation of diagnostic reagent for alcohol dependence syndrome

A technology for alcohol dependence and syndrome, applied in the determination/testing of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve problems such as deficiency, and achieve the effect of convenient and easy diagnosis

Pending Publication Date: 2019-08-23
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, studies using exosomes to identify a novel circulating biomarker for detecting alcohol dependence syndromes are still lacking

Method used

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  • Application of serum exosome has_circ_0004771 in preparation of diagnostic reagent for alcohol dependence syndrome
  • Application of serum exosome has_circ_0004771 in preparation of diagnostic reagent for alcohol dependence syndrome
  • Application of serum exosome has_circ_0004771 in preparation of diagnostic reagent for alcohol dependence syndrome

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Experimental program
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Embodiment 1

[0021] 1. Group selection

[0022] Thirty-seven age-matched healthy volunteers (non-AD controls) and 60 AD patients were included in this study. All patients were consecutively admitted to the Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University from December 2016 to December 2018. The inclusion criteria of AD patients are: 1. The age ranges from 18 to 80 years old. 2. The current diagnosis of AD conforms to the DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) criteria. 3. Still drinking alcohol within one week before admission. 4. Sufficient cognitive level to complete basic research interviews (MMSE score >10). 5. Volunteer to provide blood samples for exosome and circular RNA analysis. The age-matched non-AD control group were healthy volunteers from the community near Sun Yat-sen Memorial Hospital, who were recruited by advertisement. To meet the criteria for comparison,

[0023] The study subjects were either abstainers or soc...

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Abstract

The invention discloses application of a serum exosome has_circ_0004771 in preparation of a diagnostic reagent for the alcohol dependence syndrome (AD). According to the application, by studying changes of the expression of circ RNA in a serum exosome of a patient with the alcohol dependence syndrome, the circ RNA with the most prominent significance is screened out, and when applied to clinical detection of the AD, the circ RNA achieves the specific effectiveness. The serum exosome has_circ_0004771 achieves the high value of diagnosing the AD, the expression level of the serum exosome has_circ_0004771 is related to the severity degree of the AD, and the serum exosome has_circ_0004771 can be taken as a marker for AD diagnosis and evaluation of the severity degree of the AD. Through the serum circ RNA marker and development and application of diagnostic kits, diagnosis for the AD can be more convenient and easy to implement, the foundation is laid for quickly and accurately mastering the illness state of the patient by a clinician and improving the clinical treatment effect, and assistance is provided for discovery of novel small molecule drug targets with the potential treatment value.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a serum exosome circular biomarker has_circ_0004771 for the diagnosis and severity assessment of alcohol dependence syndrome, its detection primer, a kit for detecting the marker, and the detection primer , the kit for detecting the marker or the application of the marker in the diagnosis and severity assessment of alcohol dependence syndrome. Background technique [0002] Alcohol dependence syndrome (AD) is defined as uncontrollable alcohol consumption in patients with negative effects on physical and mental health and interpersonal relationships. AD is very common in both developed and developing countries, with a prevalence of approximately 10% of the global population. Although careful efforts have been made to develop a DSM-IV / v based interview format for AD screening, less than 15% of patients are reported to be diagnosed and treated. Therefore, exploring a new bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/178C12Q2600/158C12Q2600/112C12Q1/6806C12Q1/6851
Inventor 彭英刘云云
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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