Liquid spin coating 3D printing method

Abstract

A liquid-phase spin-coating 3D printing method, the method comprising the following operations: establishing a digital model of the bottom mold, making a solid model of the bottom mold; obtaining a digital model of the piece to be formed on the digital model of the bottom mold; The model is used for 3D printing path planning, and the extrusion method is used to support the molding surface of the bottom mold, and the liquid bio-ink is coated on the surface of the bottom mold by the liquid phase spin coating method, and the bio-ink is in the liquid phase range during extrusion; extrusion During the process, the bio-ink remains liquid; after the extrusion is completed, the bio-ink is solidified to obtain a molded part whose bottom surface matches the bottom mold. The advantage of the present invention is that the hollow structure with high surface finish and complex curved surface can be produced by automatic 3D printing.

Description

technical field [0001] The invention relates to a 3D printing method and a printer capable of accurately forming a hollow structure with complex curved surfaces. Background technique [0002] With the development of biomanufacturing technology, 3D printing technology has become one of the important methods for tissue and organ repair, transplantation, treatment and research of major diseases. Cornea, atrium, glomerulus, ovary, etc. are all hollow structures with complex curved surfaces. The cornea is used as an example to illustrate. [0003] The shortage of corneal transplant donors is a major challenge in the field of blindness treatment in the world. Among them, there are more than 5 million in my country, and at least 100,000 new cases are added every year. Among them, 94.7% of corneal blind patients can be restored by corneal transplantation. Donations can only sustain 5,000 transplants per month. The serious shortage of donors has led to an increasing number of cornea...

AI Technical Summary

Problems solved by technology

Conventional tissue engineering methods mainly have the following problems: 1. The planar membrane structure, whose variable-curvature surface morphology is difficult to accurately control, can only obtain a planar cornea with a certain light transmittance, and cannot provide any refractive power; in clinical applications, Can only provide light to the patient, but cannot provide clear vision

2. Animal corneal exfoliated cell matrix: It is difficult to completely remove toxic reagents during the preparation process, which has a rejection reaction, and its structure cannot completely match the recipient eyeball, resulting in refractive problems

3. The preparation process is complicated and the cycle is long, it is difficult to customize according to the difference in individual shape, and the comfort is poor

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