A biological 3d printer

Abstract

A biological 3D printer, comprising a base on which a drop-type SLA molding module and an extrusion molding module are arranged; the SLA molding module and the extrusion molding module share a carrier, a carrier and a driver for the carrier connected; the SLA molding module includes a light source and a liquid tank, the stage drive includes a lifting motor and a connecting arm, and the connecting part is fixed to the stage; the extrusion molding module includes an extrusion barrel and an extrusion control device. The advantage of the present invention is that the automatic switching of the SLA forming module of the extruding printing module is used to realize the automatic 3D forming of the complex curved surface hollow structure.

Description

technical field [0001] The invention relates to a 3D printing method and a printer capable of accurately forming a hollow structure with complex curved surfaces. Background technique [0002] With the development of biomanufacturing technology, 3D printing technology has become one of the important methods for tissue and organ repair, transplantation, treatment and research of major diseases. Cornea, atrium, glomerulus, ovary, etc. are all hollow structures with complex curved surfaces. The cornea is used as an example to illustrate. [0003] The shortage of corneal transplant donors is a major challenge in the field of blindness treatment in the world. Among them, there are more than 5 million in my country, and at least 100,000 new cases are added every year. Among them, 94.7% of corneal blind patients can be restored by corneal transplantation. Donations can only sustain 5,000 transplants per month. The serious shortage of donors has led to an increasing number of cornea...

AI Technical Summary

Problems solved by technology

Conventional tissue engineering methods mainly have the following problems: 1. The planar membrane structure, whose variable-curvature surface morphology is difficult to accurately control, can only obtain a planar cornea with a certain light transmittance, and cannot provide any refractive power; in clinical applications, Can only provide light to the patient, but cannot provide clear vision

2. Animal corneal exfoliated cell matrix: It is difficult to completely remove toxic reagents during the preparation process, which has a rejection reaction, and its structure cannot completely match the recipient eyeball, resulting in refractive problems

3. The preparation process is complicated and the cycle is long, it is difficult to customize according to the difference in individual shape, and the comfort is poor

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