Diet composition for the prevention and/or the treatment of endometrial hyperplasia

A technology of endometrial hyperplasia and diet, which is applied in the direction of food ingredients, functions of food ingredients, endocrine system diseases, etc., can solve problems such as inability to make fasting or FMD curative effect

Inactive Publication Date: 2019-11-01
UNIV DEGLI STUDI DI GENOVA GENOVA IT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, no reliable predictions can be made of the likely benefit of fasting or FMD for the prevention and / or treatment of endometrial hyperplasia, especially after the use of tamoxifen or other selective estrogen receptor modulators

Method used

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  • Diet composition for the prevention and/or the treatment of endometrial hyperplasia
  • Diet composition for the prevention and/or the treatment of endometrial hyperplasia
  • Diet composition for the prevention and/or the treatment of endometrial hyperplasia

Examples

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Embodiment Construction

[0060] The present invention relates to a dietary composition as described above for the prevention and / or treatment of endometrial hyperplasia. The dietary composition is as described above for women at risk of developing endometrial hyperplasia or with a previous diagnosis of endometrial hyperplasia (after HRT or ingestion of tamoxifen, in the Indications for use of this dietary ingredient exist, especially when menstrual irregularities reflect polycystic ovary syndrome). In particular, the use of this dietary component does not preclude hysterectomy in the presence of atypical hyperplasia requiring hysterectomy.

[0061] found that animals treated for four weeks with tamoxifen, a drug that induces endometrial hyperplasia as a partial ER stimulant at the uterine level, had increased uterine weight ( figure 1 A and figure 1 B is visible), the size of the uterus itself increases ( figure 2 ) and the histological pattern of endometrial hyperplasia ( image 3 ), which sup...

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Abstract

Diet composition for use in the prevention and / or the treatment of endometrial hyperplasia in a human subject comprising a) a fasting mimicking diet component to be administered for a first period oftime and providing less than 50% of the normal caloric intake of the subject with both protein restriction and sugar restriction; and b) a re-feeding diet component to be administered for a second time period, which provides 60-100% of the normal caloric intake of the subject, wherein the fasting mimicking diet component and the re-feeding diet component are administered over multiple cycles.

Description

technical field [0001] The technical field of the invention relates to the technical fields of the pharmaceutical and food industries. [0002] In particular, the present invention relates to dietary ingredients for the prevention and / or treatment of endometrial hyperplasia in human subjects. Background technique [0003] Endometrial hyperplasia is a condition characterized by thickening of the uterine lining (endometrium) in response to estrogen levels disproportionate to progesterone levels (https: / / www.rcog.org.uk / globalassets / documents / guidelines / green-topguidelines / gtg_67_endometrial_hyperplasia.pdf). [0004] Conditions that predispose to endometrial hyperplasia include use of selective estrogen receptor modulators (ERs), such as tamoxifen (a drug used to treat breast cancer), postmenopausal estrogen intake [hormone replacement therapy (HRT)] , obesity, and menstrual irregularities, especially in women with polycystic ovary syndrome. Endometrial hyperplasia can cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L33/20
CPCA23L33/30A23L33/20A61P15/00A61P15/12A61P5/32A23V2002/00A23V2200/332A23L33/12A23L33/125A23L33/185
Inventor 阿莱西奥·内西奥尼艾琳·卡法帕梅拉·贝切里尼瓦尔特·隆戈
Owner UNIV DEGLI STUDI DI GENOVA GENOVA IT
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