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Hydroxyapatite functionalized monolithic column prepared by in situ mineralization method

A hydroxyapatite, in-situ mineralization technology, applied in chemical instruments and methods, separation methods, solid adsorbent liquid separation, etc., can solve problems such as uneven distribution of HAP and decreased column permeability.

Active Publication Date: 2021-09-10
福州佳宸生物科技有限公司
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Problems solved by technology

In view of the problems of decreased column permeability and uneven distribution of HAP in the HAP functionalized monolithic column prepared by the in-situ doping method, the HAP functionalized monolithic column prepared by the present invention maintains the excellent permeability of the matrix monolithic column, Moreover, the distribution of HAP on the surface of the monolithic column is more uniform, which is expected to further improve the enrichment and extraction performance of the HAP functionalized monolithic column

Method used

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  • Hydroxyapatite functionalized monolithic column prepared by in situ mineralization method
  • Hydroxyapatite functionalized monolithic column prepared by in situ mineralization method
  • Hydroxyapatite functionalized monolithic column prepared by in situ mineralization method

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preparation example Construction

[0028] (1) Preparation of Monolithic Column: chromatographically pure methanol ATC PTFE washed for half an hour, and then placed in an oven at 60 ℃ drying; a concentration of 1g / mL aqueous urea solution, mass fraction of 37% formaldehyde solution and 0.1mol / L hydrochloric acid solution of 4: 5: 1 by volume mixed ratio of charged Teflon tube previously washed in a reaction 10 to 120 minutes to obtain urea-formaldehyde resin at 45-65 deg.] C in a water bath Monolithic column (in table 1 for some specific examples).

[0029] Table 1 Preparation Conditions urea-formaldehyde resin Monolithic Column

[0030] Serial number Condefficient temperature (° C) Reaction time (min) a 45 60 b 45 120 c 55 10 d 55 30 e 55 60 f 55 120 g 65 10 h 65 30

[0031] (2) Coating of dopamine: water flushed through the UF support micro-infusion pump monolith one hour to remove unreacted substances within the column; the same time, taking 5mL 1...

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Abstract

The invention discloses a hydroxyapatite functional monolithic column prepared by an in-situ mineralization method; the invention uses urea solution, formaldehyde solution and an acidic catalyst as raw materials to prepare a urea-formaldehyde resin matrix through an acid-initiated one-step in-situ dehydration polycondensation technology monolithic column; then pass dopamine solution into the matrix monolithic column to realize the coating of polydopamine on the matrix monolithic column surface; then pass simulated body fluid into the monolithic column, utilize the catechol amino group on the surface of polydopamine to simulate body fluid The precipitation of calcium ions and phosphate ions induces the formation of hydroxyapatite, and a new type of hydroxyapatite functionalized monolithic column was prepared, which was applied to solid-phase (micro) extraction to achieve online enrichment and extraction of phosphorylated substances. High-sensitivity detection; the invention has simple process, easy operation, no need of expensive instruments, easy popularization, and a wide range of applicable analysis objects.

Description

Technical field [0001] The present invention is in the field of preparing the entire column of hydroxyapatite particularly relates to functionalized monolithic column prepared in situ mineralization process. Background technique [0002] A rod-shaped monolith prepared from whole inner tube by a process in situ polymerization. Because of its monolithic column having a simple preparation method, various surface-functionalized, excellent in permeability and fast mass transfer rates, etc., it has been attracting attention in the field of continuing environmental testing, food and drug safety analysis. Structural advantage is that both the monolith penetrating each other micron-scale pores, there skeleton nanoscale pores, which makes the overall column both high permeability and a large specific surface area, for highly efficient solid phase extraction, rapid, high-throughput and low back pressure and other characteristics, and show great potential in complex samples before processing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/22G01N30/06G01N30/08
CPCB01D15/22G01N30/06G01N30/08G01N2030/062
Inventor 王家斌戴永伟
Owner 福州佳宸生物科技有限公司
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