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Excellent lactobacillus reuteri for preventing ulcerative colitis

A technology of ulcerative colitis and Lactobacillus reuteri, applied in the field of microbiology, can solve the problems of ulcerative colitis patents that have not yet been published

Inactive Publication Date: 2019-12-20
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among the patents related to Lactobacillus reuteri in the past 10 years, the patent that clarifies that Lactobacillus reuteri can prevent ulcerative colitis has not yet been published

Method used

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  • Excellent lactobacillus reuteri for preventing ulcerative colitis
  • Excellent lactobacillus reuteri for preventing ulcerative colitis
  • Excellent lactobacillus reuteri for preventing ulcerative colitis

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Embodiment Construction

[0028] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0029] An excellent strain of Lactobacillus reuteri for the prevention of ulcerative colitis has been deposited in the General Microbiology Center of the China Committee for the Collection of Microorganisms on May 27, 2019, and the preservation number is: CGMCC NO.17853.

[0030] The strain was isolated from the intestinal contents of Songliao black piglets.

[0031] The morphology of Lactobacillus reuteri RAM0101 under the microscope is as follows figure 1 , end round, single or paired, short chai...

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Abstract

The present invention provides lactobacillus reuteri for preventing ulcerative colitis. The strain is named as lactobacillus reuteri RAM0101 and deposited on May 27, 2019 at China General Microbiological Culture Collection Center and has a preservation number of CGMCC NO.17853. C57BL / 6N mice are used as test objects, dextran sodium sulfate (DSS) is used to induce the mice to form an ulcerative colitis model and the model is also used to investigate effectiveness of the strain in preventing the ulcerative colitis. The lactobacillus reuteri can relieve weight loss, diarrhea, hematochezia and disease activity index (DAI) score of the ulcerative colitis mice induced by the DSS, protects pathological damages of colon tissues of the mice induced by the DSS, can enhance colon tissue epithelial barrier completeness and is also free of toxin and harms.

Description

technical field [0001] The invention relates to the field of microbiology, in particular to an excellent Lactobacillus reuteri strain used for preventing ulcerative colitis. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease that occurs in the colon and small intestine, including ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs in genetically susceptible individuals and is caused by an overactive T cell-mediated immune response to specific components of the gut microbiota, susceptible to recurrent episodes of environmental influences. The specific pathogenesis of IBD is still unclear, but it is generally believed to be caused by the combined effects of host genes, environmental factors, intestinal microorganisms and immune response. However, more and more studies have confirmed that gut microbes (bacteria, fungi and viruses) play a key role in the development of IBD. Early in the onset of IBD, the divers...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/747A61P1/00A61P1/04C12R1/225
CPCC12N1/20A61K35/747A61P1/00A61P1/04C12R2001/225C12N1/205
Inventor 相宏宇宁可谢秋宏王彦博张莹
Owner JILIN UNIV
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