Purpose of Dencichine to preparation of medicines for treating inflammatory intestinal diseases

A technology for inflammatory bowel disease and application, applied in the field of preparing medicines for treating inflammatory bowel disease, can solve the problems of external environment stimulation, indeterminate conclusion on the pathogenesis of inflammatory bowel disease, imbalance of intestinal flora, etc., and achieve good treatment effect of effect

Pending Publication Date: 2020-01-03
SHANGHAI CHANGHAI HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the pathogenesis of inflammatory bowel disease has not yet been clearly determined, and it may be re

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  • Purpose of Dencichine to preparation of medicines for treating inflammatory intestinal diseases
  • Purpose of Dencichine to preparation of medicines for treating inflammatory intestinal diseases
  • Purpose of Dencichine to preparation of medicines for treating inflammatory intestinal diseases

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Embodiment Construction

[0014] The present invention is illustrated below in conjunction with examples, but the present invention is not limited. In the field, simple replacements or improvements made by skilled persons to the present invention all belong to the technical solutions protected by the present invention.

[0015] Materials and Methods:

[0016] Mice: Male wild-type C57 mice (6-8 weeks) were purchased from Chinese Academy of Sciences (Shanghai). All mice were bred in the Special Pathogen Free (SPF) laboratory of Animal Experiment Center of Second Military Medical University (Shanghai). The mice in the treatment group were given intraperitoneal injection of 50ug / ml Dencichine (purchased from Shanghai Yuanxi Biotechnology Co., Ltd.) for 3 consecutive days, and then were given 1.5% DSS (40,000kDa; ICN Biochemicals) drinking water orally for 7 days and then switched to normal drinking water. The mice in the control group and the mice in the treatment group were given 1.5% DSS drinking water...

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Abstract

The invention relates to the field of biological pharmaceuticals, in particular to a purpose of Dencichine to preparation of medicines for treating inflammatory intestinal diseases.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the use of Dencichine in the preparation of medicines for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic relapsing disease characterized by non-specific intestinal inflammatory damage, including ulcerative colitis (UC) and Crohn's disease. Through colonoscopy, intestinal mucosal hyperemia, edema, granular changes, and even ulceration can be observed; histopathologically, extensive ulceration in the lesion area is accompanied by a large number of neutrophil infiltration and intestinal mucosal necrosis. However, the pathogenesis of inflammatory bowel disease has not yet been clearly determined, and it may be related to genetic susceptibility, external environmental stimuli, autoimmunity, and intestinal flora imbalance. [0003] Dencichin is a non-protein amino acid isolated from Panax notoginseng, which can inhibit the ac...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P1/00
CPCA61K31/198A61P1/00
Inventor 王颢施赟杰刘聪赵权权黄城郭芳琪杜继聪
Owner SHANGHAI CHANGHAI HOSPITAL
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