Anti-il-1r3 antibodies for use in inflammatory conditions

A technology for inflammatory diseases and inflammatory diseases, applied in the field of anti-IL-1R3 antibodies for inflammatory diseases, can solve problems such as hindering therapeutic use
CN110831670APending Publication Date: 2020-02-21SANOFI BIOTECH SAS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SANOFI BIOTECH SAS
Publication Date
2020-02-21

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Abstract

The present invention relates to methods for treating medical conditions and / or disorders characterized by uncontrolled or abnormal expression of members of the IL1R3 signaling pathway such as IL-lalpha, IL-Ibeta, IL-33, IL-36, IL1RA and / or IL1R3, as well as variants thereof. More specifically, the present invention relates to anti-IL1R3 antibodies for use in the treatment of an ILlR3-mediated inflammatory condition and / or disorder in a subject. Such conditions and disorders include but are not limited to inflammatory diseases, immune disorders, fibrotic disorders, eosinophilic disorders, infection, pain, a central nervous system disorder, an ophthalmologic disorder, Hereditary Systemic Inflammatory Diseases, and Systemic and Local Inflammatory Diseases and cancer associated chronic inflammation.
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Description

Technical field

[0001] The present invention relates to a method for treating medical conditions and / or diseases characterized by uncontrolled or abnormal expression of IL1R3 signaling pathway members such as IL-1α, IL-1β, IL-33, IL-36, IL1RA, and / or IL1R3. More specifically, the present invention relates to methods and uses of anti-IL-1R3 antibodies in inflammatory conditions and / or diseases. Background technique

[0002] Interleukin 1 receptor accessory protein (IL1RAP), also known as IL1R3, is a co-receptor for type 1 interleukin 1 receptor (IL1R1) and is indispensable for the transmission of IL-1 signaling. Once IL-1 is bound, IL-1R1 associates with IL-1RAcP to form a functional signaling receptor complex, which stimulates NFkB activity.

[0003] IL-33, its receptor ST2 and IL-1RAcP also form a complex (IL-33 / ST2 / IL-1RAcP) whose activity is similar to the IL-1β / IL-1R1 / IL-1RAcP complex in terms of NFkB activation. IL-36 (IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9)), i...

Claims

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