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Cosmetic composition for improving skin aging or skin wrinkle

A cosmetic composition and skin wrinkle technology, applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., can solve problems such as skin aging prevention or wrinkle improvement effects that have not yet been revealed, and achieve the effect of wrinkle improvement and skin aging prevention

Active Publication Date: 2020-02-28
COSMAX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when chrysanthemum, aloe, and foreign ivy are used, no skin aging prevention or wrinkle improvement effects have been revealed

Method used

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  • Cosmetic composition for improving skin aging or skin wrinkle
  • Cosmetic composition for improving skin aging or skin wrinkle
  • Cosmetic composition for improving skin aging or skin wrinkle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of the mixed extract of chrysanthemum, aloe and ivy

[0038] As shown in Table 1 below, the individual extracts of chrysanthemum, aloe, and ivy obtained in Comparative Example 1 above were mixed to obtain a mixed extract.

[0039] Table 1

[0040]

experiment example 1

[0041] Experimental example 1: Induction effect of type Ⅰ collagen gene expression of mixed extracts of chrysanthemum, aloe and foreign ivy Determination of

[0042] In order to determine the induction effect of type Ⅰ collagen gene expression of the mixed extracts of chrysanthemum, aloe and ivy, the corresponding extracts were provided from the skin laboratory and used in the following experiments.

[0043] Specifically, in a human fibroblast cell line (Human dermal fibroblast, Hs68), experiments were performed under the following conditions. First, with 3.5x10 5 After dispensing Hs68 fibroblasts into 6-well plates, incubate at 37°C, 5% CO 2 conditioned medium for 24 hours. Afterwards, remove the culture medium, put into phosphate buffered saline (DPBS) and wash with water, after replacing the culture medium without fetal bovine serum (FBS), be divided into processing chrysanthemum, aloe, foreign ivy extract 1% (10ul / ml) group and the group treated so that the final m...

experiment example 2

[0045] Experimental Example 2: Evaluation of MMP-1 Expression Inhibition Ability of Chrysanthemum, Aloe and Ivy Mixed Extracts

[0046] In order to evaluate the synergistic effect on the inhibition of MMP-1 expression caused by the overexpression of the mixed extracts of chrysanthemum, aloe and ivy due to ultraviolet rays, the expression of MMP-1 in a human dermal fibroblast cell line (Human dermal fibroblast, Hs68) was confirmed Inhibition.

[0047] First, with 3.5x10 5 After dispensing Hs68 cells into 6-well plates, incubate at 37°C, 5% CO 2 conditioned medium for 24 hours. After that, the culture medium was removed, and after putting into phosphate buffer, 12 mJ / cm was irradiated in the remaining cell groups except the outdoor ultraviolet (UVB) non-irradiated group. 2 After outdoor UV exposure, replace with FBS-free medium. In addition, it was divided into a group in which 0.1% (1ul / ml) of chrysanthemum, aloe, and foreign ivy extracts were individually treated, and the ...

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PUM

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Abstract

The present invention relates to a cosmetic composition for improving skin aging or skin wrinkles, which contains a chrysanthemum, aloe and hedera helix mixed extract as an active ingredient, and morespecifically, to an external preparation composition for skin, which contains an extract for effectively improving skin wrinkles by suppressing skin aging caused by ultraviolet light. According to the present invention, the cosmetic composition containing a chrysanthemum, aloe, and hedera helix mixed extract as an active ingredient increases the expression of COL1A1, which is a collagen biosynthetic gene, and inhibits the expression of MMP-1, which is a collagenolytic enzyme, thereby exhibiting a skin aging prevention or wrinkle improvement effect.

Description

technical field [0001] The present invention relates to a cosmetic composition for improving skin aging or skin wrinkles comprising a mixed extract of chrysanthemum, aloe, and foreign ivy as active ingredients, and more particularly, to a cosmetic composition comprising an extract effective in improving wrinkles by inhibiting skin aging caused by ultraviolet rays Skin external preparation composition. Background technique [0002] As the outermost organ existing in the body, the skin protects our body from the external environment and stimuli. Compared with many organs in the body, the skin is constantly exposed to external stimuli and thus can be easily attacked, especially in the case of facial skin, which is directly exposed to ultraviolet rays and pollutants and thus has a higher vulnerability compared to other body skin. characteristics of aging. [0003] Skin aging is divided into intrinsic aging due to genetic factors and exogenous aging due to environmental exposur...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9794A61Q17/04A61Q19/00A61Q19/08
CPCA61K8/9789A61K8/9794A61Q19/00A61Q19/08A61Q17/04A61K2800/782A61K8/9783
Inventor 庆瑞娟李敬银吕炫周姜承贤朴明三
Owner COSMAX INC
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