Application of benzisoselenazole derivative combined with platinum drug to preparation of tumor treatment drugs and postoperative tumor recurrence drugs

Abstract

The invention belongs to the technical field of tumor treatment, and discloses application of a benzisoselenazole derivative combined with a platinum drug to the preparation of tumor treatment drugs and postoperative tumor recurrence drugs. The benziselenazole derivative has a structure as shown in the formula A, the platinum-based anticancer drug is selected from at least one of cisplatin, carboplatin, oxaliplatin, nedaplatin, and the like. The molar ratio of the benziselenazole derivative to the platinum-based anticancer drug is (1-99): (1-99). With the combination of the benzisoselenazole derivative and the platinum drug, the dosage of platinum-based anticancer drug with high toxicity can be effectively reduced and the safety of anticancer drugs can be improved; and Bel-7402 cell apoptosis can be induced by reducing Bcl-2 / Bax protein expression ratio, and the expression of TrxR in tumor tissues can be synergistically inhibited, the proliferation rate of tumor cells after operation can be significantly reduced, and the growth inhibition rate of tumor cells after operation can be improved.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and specifically relates to the application of a benzisoselenazole derivative combined with a platinum drug in the preparation of a drug for treating tumor and a drug for postoperative tumor recurrence. Background technique [0002] Tumors, especially malignant tumors, are global killers of human health and one of the main causes of high mortality from diseases. Clinical treatment methods for tumors mainly include surgery, radiotherapy and chemotherapy. However, even after the above treatments, the probability of rapid tumor proliferation and recurrence remains high, making anticancer treatment one of the most challenging problems worldwide. [0003] The survival of cancer cells in the body caused by incomplete cancer treatment is the main reason for the recurrence of cancer cells. The main treatment methods for cancer are surgery, radiotherapy, and chemotherapy. Surgery is a mechanical...

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Problems solved by technology

[0004] Generally speaking, recurrent cancer is more difficult than initial cancer treatment. The main reasons are: 1. Local treatments such as initial surgery or radiotherapy have eliminated cancer cells as much as possible, but there may still be some extremely small cancer cell groups, Migrated out of the scope of surgery and radiotherapy very early

These cancer cell populations are often very aggressive (rapid growth and rapid spread), that is, recurrent tumors are composed of subgroups with a very high degree of malignancy. For tumors with further increased malignancy, the difficulty of treatment will be greatly increased. Increase

2. The cancer has developed resistance to the initial chemotherapy and radiotherapy, and the side effects of the initial treatment will also lead to difficulties in the retreatment of recurrent tumors

However, when platinum-based anticancer drugs are used alone as anticancer drugs or postoperative recurrence drugs, due to their high toxicity, there must be a large gap time in use to eliminate toxicity, which affects the anticancer effect and Less effective in inhibiting cancer recurrence in postoperative patients

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