A kind of up-conversion ruthenium complex nanomaterial and its preparation and application

A nanomaterial, ruthenium complex technology, applied in the field of medicine, achieves good biocompatibility, good safety and anti-tumor effect, and enhances the effect of anti-tumor activity

Active Publication Date: 2021-12-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Utilizing rare earth up-conversion nanoparticles, improving their biocompatibility through surface modification and loading photosensitive drugs with good water-soluble ruthenium complexes in photodynamic therapy through chemical bonds has not been reported

Method used

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  • A kind of up-conversion ruthenium complex nanomaterial and its preparation and application
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  • A kind of up-conversion ruthenium complex nanomaterial and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]Mix 1 g of ligand-free upconverting nanoparticles with 8 g of human serum albumin, add 180 mL of water, mix and sonicate for 10 min; then add 8 g of bipyridyl ruthenium o-phenanthroline complex, 4 g of 1mol / L sodium chloride aqueous solution and 4 g of 2mol / L sodium hydroxide solution, stirred at 5000 rpm for 10 min; then slowly added dropwise 2.05 kg of ethanol and 4.1 kg of 5% glutaraldehyde aqueous solution, stirred at 5000 rpm for 8 h, centrifuged at 10000 rpm for 30 min, The supernatant was removed to obtain 26 g of upconverting ruthenium complex nanomaterials.

[0042] The preparation method of the ligand-free upconversion nanoparticles: mix 1 mol of sodium trifluoroacetate with 1 mol of yttrium trifluoroacetate, add 0.2 mol of ytterbium trifluoroacetate and 0.01 mol of thulium trifluoroacetate, then add 1.99 kg of oleic acid and 1-octadecene mixed solution in equimolar ratio, stirred at 5000 rpm for 10 minutes, then heated to 150°C for 20 minutes to form a light y...

Embodiment 2

[0046] Mix 1 g of ligand-free upconversion nanoparticles with 12 g of serum albumin, add 65 mL of water, mix and sonicate for 60 min, then add 12 g of bipyridyl ruthenium o-phenanthroline complex, 6 g of 0.1 mol / L sodium chloride aqueous solution and 6 g of .5mol / L sodium hydroxide solution, stirred at 1000 rpm for 60 min; slowly added dropwise 0.51 kg of methanol and 0.51 kg of 10% glutaraldehyde aqueous solution, stirred at 1000 rpm for 16 h, and centrifuged at 15000 rpm for 10 min , and the supernatant was removed to obtain 38 g of upconversion ruthenium complex nanomaterials.

[0047] The preparation method of the ligand-free upconversion nanoparticles: mix 1 mol of sodium trifluoroacetate with 1 mol of yttrium trifluoroacetate, add 0.02 mol of ytterbium trifluoroacetate and 0.002 mol of erbium trifluoroacetate, then add 3.44 kg of oleic acid and 1-octadecene equimolar ratio mixed solution, stirred at 2000 rpm for 20min, then heated to 100°C for 40min to form a light yello...

Embodiment 3

[0051] Mix 1 g of ligand-free upconverting nanoparticles with 10 g of serum albumin, add 110 mL of water, mix and sonicate for 40 min, then add 10 g of bipyridyl ruthenium o-phenanthroline complex, 5 g of 0.5 mol / L sodium chloride aqueous solution and 5 g of 1 mol / L sodium hydroxide solution, stirred for 40min; then slowly added dropwise 1.13kg of ethanol, 2.1kg mass fraction of 6% glutaraldehyde aqueous solution, stirred at 4000 rpm for 12h, then centrifuged at 12000rpm for 15min, removed the supernatant, 33 g of upconversion ruthenium complex nanomaterials were obtained.

[0052] The preparation method of the ligand-free upconversion nanoparticles: mix 1 mol of sodium trifluoroacetate with 1 mol of yttrium trifluoroacetate, add 0.05 mol of ytterbium trifluoroacetate and 0.008 mol of thulium trifluoroacetate, then add 2.12 kg of oleic acid and 1-octadecene 1:0.5 molar ratio mixed solution, stirred at 4000 rpm for 20 minutes, then heated to 140°C for 25 minutes to form a ligh...

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Abstract

The invention belongs to the field of medicine, and discloses an up-conversion ruthenium complex nanomaterial and its preparation and application. The upconversion ruthenium complex nanomaterial: the above conversion nanoparticle is used as a core carrier, and human serum albumin and bipyridyl ruthenium-o-phenanthroline complexes are loaded on the core carrier to form a core-shell structure. Method: mix the up-converting nanoparticles and serum albumin in water, add bipyridyl ruthenium-o-phenanthroline complex, sodium chloride aqueous solution and strong alkali solution, stir, add organic solvent and glutaraldehyde dropwise, and stir to react , subsequent treatment to obtain up-conversion ruthenium complex nanomaterials. The material of the present invention has the property of near-infrared up-conversion luminescence, avoids the lack of penetration ability of ruthenium complexes to stimulate blue light biological tissues, enhances its photodynamic anti-tumor activity in vivo, and has good near-infrared light anti-tumor effect and Imaging ability; application in photodynamic anti-tumor near-infrared photosensitizers and tumor imaging agents.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an upconversion ruthenium complex nanomaterial, a preparation method thereof, and an application in preparing photosensitive drugs for photodynamic therapy of tumors. Background technique [0002] Malignant tumors have become a major killer of human health and are the second leading cause of death, accounting for 15% of deaths. Cancer research and treatment is an important part of modern medicine. Photodynamic therapy is an emerging technology for diagnosis and treatment of tumors. Compared with conventional chemotherapy and radiotherapy, it has the advantages of less trauma, good selectivity, wide application range, and less toxic and side effects. [0003] Photodynamic anti-tumor therapy relies on a photosensitization reaction accompanied by biological effects involving oxygen molecules. The process includes: (1) the photosensitizer absorbed by the tissue is excited by las...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00C09K11/02C09K11/85C07F15/00C09K11/06B82Y20/00B82Y30/00B82Y40/00A61K41/00A61P35/00
CPCC09K11/025C09K11/7773C07F15/0053C09K11/06B82Y20/00B82Y30/00B82Y40/00A61K41/0057A61K49/0019A61K49/0021A61K49/0056A61P35/00C09K2211/185
Inventor 叶勇刘泽宇
Owner SOUTH CHINA UNIV OF TECH
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