Use of composition comprising stem cell-derived exosome as effective ingredient for prevention or alleviation of pruritus

A composition and exosome technology, applied in the fields of prevention, improvement or treatment of itching, skin topical preparations and cosmetic compositions, relief and inhibition, can solve the problems of anti-host disease, complex and expensive, etc.

Active Publication Date: 2020-03-06
KOREA EXOSOME BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these treatments are problematic in that they have temporary or limited therapeutic effects and show specificity depending on the type of pruritus
Also, corticosteroids and corticosteroids are problematic in that they should only be used for a short period of time in acute or severe cases due to their side effects
However, the use of allogeneic adult stem cells (not the patient's own) poses a risk of developing graft-versus-host disease
When autologous adult stem cells are used for therapy, a problem arises: the process of culturing adult stem cells isolated from patients is necessary, which is complicated and expensive
Therefore, when conditioned medium is applied to the skin, the skin is highly likely to be exposed to several risks

Method used

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  • Use of composition comprising stem cell-derived exosome as effective ingredient for prevention or alleviation of pruritus
  • Use of composition comprising stem cell-derived exosome as effective ingredient for prevention or alleviation of pruritus
  • Use of composition comprising stem cell-derived exosome as effective ingredient for prevention or alleviation of pruritus

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Embodiment Construction

[0029] In order to achieve the above objects, the present invention provides a composition for preventing, suppressing, alleviating, improving or treating pruritus, comprising stem cell-derived exosomes as an active ingredient.

[0030] The present invention also provides a clinically and commercially relevant new technology capable of obtaining large quantities of stem cell-derived exosomes that are clinically useful for preventing, inhibiting, alleviating, ameliorating and treating pruritus with high purity and uniformity Particle size distribution, wherein the technique can provide a composition comprising the obtained stem cell-derived exosomes having excellent functional activity as an active ingredient in large quantities at low cost.

[0031] The term "exosome" as used herein refers to a vesicle with a size of tens to hundreds of nanometers (preferably, about 30 to 200 nm), which is composed of a phospholipid bilayer membrane having the same structure as a cell membrane (h...

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Abstract

The present invention provides a composition comprising stem cell-derived exosomes as an effective ingredient for prevention, suppression, reduction, alleviation, or treatment of pruritus. Acting on multiple cytokine targets causative of pruritus such as IL-4, IL-31, and TSLP, a composition of the present invention can be applied to a wide spectrum of pruritus attributed to various causes and caneffectively suppress and reduce pruritus. In addition, when directly applied to the human skin, the composition of the present invention can remarkably alleviate pruritus-associated clinical indices and erythema. Therefore, the composition of the present invention can be useful as pharmaceutical compositions, skin agents for external use, and cosmetic compositions for preventing, suppressing, reducing, alleviating, or treating pruritus.

Description

technical field [0001] The present invention relates to the use of a composition comprising stem cell-derived exosomes as an active ingredient for preventing, suppressing, alleviating, improving or treating pruritus. [0002] Furthermore, the present invention relates to a pharmaceutical composition, an external skin preparation and a cosmetic composition comprising stem cell-derived exosomes for preventing, suppressing, alleviating, improving or treating itching. [0003] In addition, the present invention relates to a clinically and commercially relevant technology capable of obtaining large quantities of stem cell-derived exosomes that are clinically useful for preventing, suppressing, alleviating, ameliorating and treating pruritus with high purity and uniformity Particle size distribution, wherein the technique can provide a composition comprising the obtained stem cell-derived exosomes having excellent functional activity as an active ingredient in large quantities at lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A23L33/10A61K8/98A61Q19/00
CPCA61K8/98A61K35/28A61Q19/00A61P17/04A23L33/10A23V2002/00A23V2200/318A61K9/0009A61K47/36A61N1/0428A61N1/325
Inventor 李龙源赵柄成
Owner KOREA EXOSOME BIOTECHNOLOGY CO LTD
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